Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Abdesheikhi, Mitra, once mentioned the application of 23981-47-7, Name is 2-(6-Methoxynaphthalen-2-yl)acetic acid, molecular formula is C13H12O3, molecular weight is 216.2326, MDL number is MFCD00033105, category is phthalazine. Now introduce a scientific discovery about this category, Name: 2-(6-Methoxynaphthalen-2-yl)acetic acid.
The one-pot, four-component reaction of phthalic anhydride, hydrazine hydrate, aromatic aldehydes and malononitrile afford 3-amino-1aryl-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives in the presence of potassium carbonate in ethanol under reflux conditions. These conditions offer simplified operation, easy purification, excellent yields and environmentally benign reaction conditions. Also, this method avoids the use of expensive catalysts, toxic solvents and chromatographic separation.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem