One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 201611-92-9, Name is 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid, formurla is C13H13NO2S2. In a document, author is Abdel-Aziz, Hatem A., introducing its new discovery. Application In Synthesis of 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid.
In continuation of our endeavor with respect to the development of potent and effective isatin-based anticancer agents, we adopted the molecular hybridization approach to design and synthesize four different sets of isatin-quinazoline (6a-f and 7a-e)/phthalazine (8a-f)/quinoxaline (9a-f) hybrids. The antiproliferative activity of the target hybrids was assessed towards HT-29 (colon), ZR-75 (breast) and A-549 (lung) human cancer cell lines. Hybrids 8b-d emerged as the most active antiproliferative congener in this study. Compound 8c induced apoptosis via increasing caspase 3/7 activity by about 5-fold in the A-549 human cancer cell line. In addition, it exhibited an increase in the G1 phase and a decrease in the S and G2/M phases in the cell cycle effect assay. Furthermore, it displayed an inhibitory concentration 50% value of 9.5 mu M against multidrug-resistant NCI-H69AR lung cancer cell line. The hybrid 8c was also subjected to in vitro metabolic investigations through its incubation with rat liver microsomes and analysis of the resulting metabolites with the aid of liquid chromatography-mass spectrometry.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 201611-92-9 help many people in the next few years. Application In Synthesis of 4-Cyano-4-((phenylcarbonothioyl)thio)pentanoic acid.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem