Chemistry can be defined as the study of matter and the changes it undergoes. You’ll sometimes hear it called the central science because it is the connection between physics and all the other sciences, starting with biology. 402-50-6, Name is 1-(Trifluoromethyl)-4-vinylbenzene, molecular formula is , belongs to phthalazine compound. In a document, author is Vinnakota, Chitra, Quality Control of 1-(Trifluoromethyl)-4-vinylbenzene.
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder for which no cognition-restoring therapies exist. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain. Increasing evidence suggests a remodeling of the GABAergic system in AD, which might represent an important therapeutic target. An inverse agonist of alpha 5 subunit-containing GABAA receptors (alpha 5GABAARs), 3-(5-Methylisoxazol-3-yl)-6-[(1-methyl-1,2,3-triazol-4-yl)methyloxy]-1,2,4-triazolo[3-a]phthalazine (alpha 5IA) has cognition-enhancing properties. This study aimed to characterize the effects of alpha 5IA on amyloid beta (A beta(1-42))-induced molecular and cellular changes. Mouse primary hippocampal cultures were exposed to either A beta(1-42) alone, or alpha 5IA alone, alpha 5IA with A beta(1-42) or vehicle alone, and changes in cell viability and mRNA expression of several GABAergic signaling components were assessed. Treatment with 100 nM of alpha 5IA reduced A beta(1-42)-induced cell loss by 23.8% (p < 0.0001) after 6 h and by 17.3% after 5 days of treatment (p < 0.0001). Furthermore, we observed an A beta(1-42)-induced increase in ambient GABA levels, as well as upregulated mRNA expression of the GABAAR alpha 2,alpha 5,beta 2/3 subunits and the GABABR R1 and R2 subunits. Such changes in GABARs expression could potentially disrupt inhibitory neurotransmission and normal network activity. Treatment with alpha 5IA restored A beta(1-42)-induced changes in the expression of alpha 5GABAARs. In summary, this compound might hold neuroprotective potential and represent a new therapeutic avenue for AD. If you are hungry for even more, make sure to check my other article about 402-50-6, Quality Control of 1-(Trifluoromethyl)-4-vinylbenzene.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem