Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 36809-26-4, Name is (4-Bromophenyl)diphenylamine. In a document, author is Yu, Li-Jun, introducing its new discovery. Recommanded Product: (4-Bromophenyl)diphenylamine.
In a previous research, we found a compound named 6-(3-(trifluoromethyl)-benzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine (BM-1) much more effective in the maximal electroshock (MES) model for mouse and much safer in the neurotoxicity (NT) screening, which indicated that it may be used as antiepileptic drug. But, those evaluations were too rough. So in this study, we did more work to assess the anticonvulsant activity and the toxicity about BM-1. The peak times of protection of BM-1 after intraperitoneal injection (ip) and oral administration (po) were determined using the MES test, and the anticonvulsant activity of it was compared with the reference drug, carbamazepine, at these peak times. The rotarod test was applied to measure its neurotoxicity. When compared with the reference drug in the maximal electroshock (MES) test at the time to peak effect, it showed that BM-1 was much more effective and safer than reference drug Carbamazepine with ED50 of 11.2 mg/kg, TD50 of 72.2 mg/kg and PI of 6.5 after administration of ip, while when administered orally, that values of ED50, TD50 and PI of BM-1-1, BM-1-2 and BM-1-3 were much better than Carbamazepine and BM-1 after po. The compound BM-1 has more effective anticonvulsant activity and lower neurotoxicity administered by both ip and po. So BM-1 could may be used instead of the prescribed antiepileptic drugs (AEDs) in the future.
I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 36809-26-4 help many people in the next few years. Recommanded Product: (4-Bromophenyl)diphenylamine.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem