Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, molecular formula is , belongs to phthalazine compound. In a document, author is Elmeligie, Salwa, Computed Properties of https://www.ambeed.com/products/122-03-2.html.
In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (6b, 6e, 7b, 13a, 13c, 16a, 16d and 17a) exhibited excellent broad spectrum cytotoxic activity in NCI 5-log dose assays against the full 60 cell panel with GI(50) values ranging from 0.15 to 8.41 mu M. Moreover, the enzymatic assessment of the synthesised compounds against VEGFR-2 tyrosine kinase showed the significant inhibitory activities of the biarylureas (12b, 12c and 13c) with IC(50)s of 4.4, 2.7 and 2.5 mu M, respectively, and with 79.83, 72.58 and 71.6% inhibition of HUVEC at 10 mu M, respectively. Additionally, compounds (7b, 13c and 16a) were found to induce cell cycle arrest at S phase boundary. Compound 7b triggered a concurrent increase in cleaved caspase-3 expression level, indicating the apoptotic-induced cell death.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem