Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Ghorbani-Vaghei, Ramin, once mentioned the application of 81-48-1, Name is 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione, molecular formula is C21H15NO3, molecular weight is 329.35, MDL number is MFCD00019148, category is phthalazine. Now introduce a scientific discovery about this category, Recommanded Product: 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione.
The one-pot four-component synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones and 1H-pyrazolo[1,2-a] pyridazine-5,8-diones was carried out from the reaction between various aldehydes, malononitrile, hydrazine hydrate and phthalic anhydride or maleic anhydride at 110 degrees C in solvent-free conditions using piperidinium benzene-1,3-disulfonate nanomagnetic ionic liquid (NMIL) as a novel and reusable catalyst. Some advantages of the presented procedure are a significant reduction in cost, effective catalysis and reusability of the catalyst. NMIL was thoroughly characterized using Fourier transform infrared spectroscopy, X-ray diffraction, scanning and transmission electron microscopies, thermogravimetry, derivative thermogravimetry, Brunauer-Emmett-Teller analysis, vibrating sample magnetometry and energy-dispersive X-ray spectroscopy. The technique is developed as a suitable and safe method for the synthesis of 1H-pyrazolo[1,2-b] phthalazine-5,10-diones and 1H-pyrazolo[1,2-a] pyridazine-5,8-diones making use of an efficient and reusable green catalyst.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem