Chemistry, like all the natural sciences, Computed Properties of https://www.ambeed.com/products/524-95-8.html, begins with the direct observation of nature— in this case, of matter.524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, SMILES is NCCOB(C1=CC=CC=C1)C2=CC=CC=C2, belongs to phthalazine compound. In a document, author is Bolteau, Raphael, introduce the new discover.
For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands. Issued from the introduction of quinazoline and phthalazine scaffolds carrying an ethyl amide lateral chain and a methoxy group as bioisosteric ligands analogues of previously developed Agomelatine. The biological activity of the prepared analogues was compared with that of Agomelatine. Quinazoline and phthalazine rings proved to be a versatile scaffold for easy feasible MT1 and MT2 ligands. Potent agonists with sub-micromolar binding affinity were obtained. However, the presence of two nitrogen atoms resulted in compounds with lower affinity for both MT1 and MT2, in comparison with the parent compound, balanced by the exhibition of good pharmacokinetic properties. (C) 2020 Elsevier Masson SAS. All rights reserved.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 524-95-8. Computed Properties of https://www.ambeed.com/products/524-95-8.html.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem