Month: May 2021

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, Computed Properties of https://www.ambeed.com/products/108-36-1.html, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 108-36-1, Name is 1,3-Dibromobenzene, molecular formula is C6H4Br2. In an article, author is Musa, Ahmed Y.,once mentioned of 108-36-1.

The abilities of phthalazine derivatives, including phthalazine (PT), phthalazone (PTO) and phthalhydrazide (PTD), to inhibit the corrosion of mild steel in 1 M HCl at 30 degrees C were studied using electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization measurements. Theoretical calculations were performed to investigate the electronic structures of the PT derivatives. Our results showed that the inhibition efficiencies of these derivatives improved with increases in concentration. The data also showed that PTD < PT < PTO in terms of the inhibiting efficiency. Theoretical calculations also revealed that PTO is expected to be the best inhibitor among the studied phthalazine derivatives. (C) 2011 Elsevier Ltd. All rights reserved. If you’re interested in learning more about 108-36-1. The above is the message from the blog manager. Computed Properties of https://www.ambeed.com/products/108-36-1.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

838-88-0, Name is 4,4′-Methylenebis(2-methylaniline), molecular formula is C15H18N2, belongs to phthalazine compound, is a common compound. In a patnet, author is Revathy, Krishnan, once mentioned the new application about 838-88-0, Recommanded Product: 4,4′-Methylenebis(2-methylaniline).

We have developed a potential method for the synthesis of biologically activel 2,2′-dimethyl-13-phenyl-2,3-dihydro-1H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione and its derivatives via an one-pot, four-component synthesis of phthalic anhydride, hydrazine, aromatic aldehydes and dimedone in the presence of ceric ammonium nitrate (CAN) at room temperature. The reaction was completed within 30 min yielding 70-90% of the corresponding product. The reaction was extended to different aldehydes and anhydrides leading to good yields in all the cases.

If you’re interested in learning more about 838-88-0. The above is the message from the blog manager. Recommanded Product: 4,4′-Methylenebis(2-methylaniline).

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, molecular formula is , belongs to phthalazine compound. In a document, author is Elmeligie, Salwa, Computed Properties of https://www.ambeed.com/products/122-03-2.html.

In the designed compounds, either a biarylamide or biarylurea moiety or an N-substituted piperazine motif was linked to position 1 of the phthalazine core. The anti-proliferative activity of the synthesised compounds revealed that eight compounds (6b, 6e, 7b, 13a, 13c, 16a, 16d and 17a) exhibited excellent broad spectrum cytotoxic activity in NCI 5-log dose assays against the full 60 cell panel with GI(50) values ranging from 0.15 to 8.41 mu M. Moreover, the enzymatic assessment of the synthesised compounds against VEGFR-2 tyrosine kinase showed the significant inhibitory activities of the biarylureas (12b, 12c and 13c) with IC(50)s of 4.4, 2.7 and 2.5 mu M, respectively, and with 79.83, 72.58 and 71.6% inhibition of HUVEC at 10 mu M, respectively. Additionally, compounds (7b, 13c and 16a) were found to induce cell cycle arrest at S phase boundary. Compound 7b triggered a concurrent increase in cleaved caspase-3 expression level, indicating the apoptotic-induced cell death.

If you are hungry for even more, make sure to check my other article about 122-03-2, Computed Properties of https://www.ambeed.com/products/122-03-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, 31618-90-3, Name is (Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate, SMILES is O=S(C1=CC=C(C)C=C1)(OCP(OCC)(OCC)=O)=O, belongs to phthalazine compound. In a document, author is Berber, Nurcan, introduce the new discover, Safety of (Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate.

A new series of phthalazine substituted urea and thiourea derivatives were synthesized, and their inhibitory effects on the activity of purified human carbonic anhydrases (hCAs I and II) were evaluated. 2H-Indazolo[2,1-b]phthalazine-trione derivative (1) was prepared with 4-nitrobenzaldehyde, dimedone, and phthalhydrazide in the presence of TFA in DMF, and nitro group was reduced to amine derivative (2) with SnCl2 center dot 2H(2)O. The compound was reacted with isocyanates and isothiocyanates to get the final products (3a-p). The results showed that all the synthesized compounds inhibited the CA isoenzymes activity. 3a (IC50 = 6.40 mu M for hCA I and 6.13 mu M for hCA II) has the most inhibitory effect. The synthesized compounds are very bulky to be able to bind near the zinc ion, and they much more probably bind as the coumarin derivatives.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 31618-90-3 is helpful to your research. Safety of (Diethoxyphosphoryl)methyl 4-methylbenzenesulfonate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 875-74-1, Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. 875-74-1, Name is H-D-Phg-OH, SMILES is O=C(O)[C@H](N)C1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Eswararao, S., V, introduce new discover of the category.

1H-pyrazolo[1,2-b]phthalazine-5,10-diones (5) and 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones (7) have been synthesized by one pot, four-component method. To synthesise them phthalic anhydride (1), hydrazine hydrate (2), benzaldehydes (3) and malononitrile (4a) /ethyl cynoacetate (4b) /dimedone (6) in refluxing water for 1-1.5 h in the presence of InCl3 as a catalyst yielding 75-85%. These reactions have an easy workup, provides excellent yields, and uses water as the solvent which is considered to be relatively environmentally benign. The structures of the products were established from their spectral properties IR, H-1-NMR, C-13-NMR & Mass spectroscopy.

Synthetic Route of 875-74-1, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 875-74-1.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. COA of Formula: https://www.ambeed.com/products/1439-36-7.html, 1439-36-7, Name is 1-(Triphenylphosphoranylidene)propan-2-one, SMILES is CC(C=P(C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3)=O, in an article , author is Shafe-Mehrabadi, Sayed Rasul, once mentioned of 1439-36-7.

Nanostructured SiO2-H2SO4 as an efficient and nano catalyst for one-pot synthesis of phtahalazines via three-component condensation of an aromatic or aliphatic aldehyde, malononitrile and 5-amino-2,3-dihydro-phthalazine-1,4-dione. Nanostructured SiO2-H2SO4 was synthesized and characterized via FT-IR and SEM techniques. It is rapid and efficient catalyst for one-pot synthesis of the biologically important 3,9-diamino-5,10-dioxo-1-aryl-5,10-dihydropyrazolo[1,2-b]phthalazine-2-carbonitrile derivatives. The significant features of this methodology are nontoxic catalyst, short reaction time (10 min), recyclability, low catalyst loading, green organic solvent (ethanol), and avoiding tedious purification step.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 1439-36-7, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/1439-36-7.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Synthetic Route of 502496-34-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a article, author is Amirmahani, Najmeh, introduce new discover of the category.

Tetrabutyl phosphonium sulfate ([TBP](2)SO4), as novel room-temperature ionic liquid (RTIL), was synthesized by a simple cost-effective method, characterized by H-1, C-13, P-31 NMR and FT-IR spectrophotometry. The newly prepared catalyst was used as an efficient catalyst in some four multicomponent reactions (4MCRs) e. g., to synthesis pyridazino[1,2-a]indazole, indazolo[2,1-b]phthalazine and pyrazolo[1,2-b]phthalazine. This green method has several advantages such as short reaction time, using simple methods to prepare catalysts and products, easy operation and high efficiency of products. In addition, the catalyst can be easily recovered and reused several times with reduced average activity. Graphic abstract

Synthetic Route of 502496-34-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 502496-34-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Selvaraj, Keerthana, once mentioned the application of 117-34-0, Quality Control of 2,2-Diphenylacetic acid, Name is 2,2-Diphenylacetic acid, molecular formula is C14H12O2, molecular weight is 212.2439, MDL number is MFCD00004251, category is phthalazine. Now introduce a scientific discovery about this category.

Novel one-pot synthesis naphtho[2,3-g]phthalazine (1a-1k) of Mannich base derivatives can be achieved via grindstone chemistry using a Tel-Cu-NPs (telmisartan-copper nanoparticles) catalyst. This method offers efficient mild reaction conditions and high yields. Tyrosinase inhibitory activity was evaluated for all synthesized compounds, along with analysis of kinetic behavior and molecular docking studies. The synthesized compound, 1c was (IC50 = 11.5 mu M) more active than kojic acid (IC50 = 78.0 mu M). Lineweaver Burk plots were used to analyze the kinetic behavior of the most active compound 1c, it was reversible and competitive behavior. Compound 1c and kojic acid occurred in the presence of 2-hydroxyketone, which has the same inhibitory mechanism. The molecular docking of compound 1c and the control kojic acid were docked against 2Y9X protein via the Schrodinger Suite. The compound 1c showed a respectable dock score (-5.6 kcal/mol) compared to kojic acid with a dock score of (-5.2 kcal/mol) in the 2Y9X protein. Cytotoxicity activity was also evaluated by using HepG2 (liver), MCF-7 (breast), and HeLa (cervical) cancer cell lines, and high activity for 1c (GI(50) = 0.01, 0.03, and 0.04 mu M, respectively) against all cell lines was found compared to standard and other compounds. Therefore, this study succeeded in testing a few promising molecules as potential antityrosinase agents.

If you are interested in 117-34-0, you can contact me at any time and look forward to more communication. Quality Control of 2,2-Diphenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 502496-34-6, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 502496-34-6, Name is 4-Bromo-2-fluoro-6-nitrotoluene, SMILES is CC1=C([N+]([O-])=O)C=C(Br)C=C1F, belongs to phthalazine compound. In a article, author is Fallah-Ghasemi Gildeh, Sara, introduce new discover of the category.

Benzylation of DBU followed by anion exchange of the resulting salt with trifluoroacetate gave nearly quantitatively the ionic liquid [Bn-DBU][TFA]. It is shown here to be an efficient catalyst for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dionesviathe three-component reaction of phthalhydrazide, aromatic aldehydes, and active alpha-methylene nitriles. DFT calculations at the B3LYP/SVP level and the experimental results are in agreement with a three-step mechanism for this reaction. Based on the DFT calculations, the catalytic effect largely arises from the intrinsic ionic properties of the ionic liquid rather than its action as a simple base. These calculations also predict the existence of two close-in-energy activated complexes whose rate determining roles and energies depend on their interaction with the anionic component of the ionic liquid, as [Bn-DBU][TFA] has shown a higher catalytic activity than [Bn-DBU][OAc]. This mechanistic approach opens up new and promising insights into the rational design of ionic liquid catalysts for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones. The synthetic method presented here has several prominent advantages.

Reference of 502496-34-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 502496-34-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 371-42-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 371-42-6, Name is 4-Fluorothiophenol, SMILES is SC1=CC=C(F)C=C1, belongs to phthalazine compound. In a article, author is Hasaninejed, Alireza, introduce new discover of the category.

A green practical method for the efficient synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-triones using sulfuric acid-modified polyethylene glycol-6000 (PEG-OSO3H) as an eco-friendly polymeric catalyst from the four-component condensation reaction of phthalic anhydride, hydrazinium hydroxide, 1,3-cyclohexanedione or 5,5-dimethyl 1,3-cyclohexanedione (dimedone) and aromatic aldehydes under solvent-free conditions at 80 degrees C is described. This approach allowed the environmental impact factor (E-factor) to be minimized. (C) 2012 Elsevier B. V. All rights reserved.

Related Products of 371-42-6, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 371-42-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem