Month: May 2021

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, molecular formula is C10H12O, belongs to phthalazine compound. In a document, author is Kiasat, Ali Reza, introduce the new discover, COA of Formula: https://www.ambeed.com/products/122-03-2.html.

A simple, efficient, and high yielding one-pot protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives has been developed by three-component coupling of phthalhydrazide, dimedone and some aromatic aldehydes in ecofriendly neat conditions promoted by nano-gamma-alumina sulforic acid. This protocol avoids the use of expensive catalysts, toxic solvents and chromatographic separation. Also the proposed protocol was extended to the linear beta-diketone (acetylaceton) instead of cyclic diketone (dimedone). The generality and functional tolerance of this convergent and environmentally benign method is demonstrated. The nature of each step of the suggested mechanism for this condensation reaction is also identified through Density Functional Theory (DFT) calculations using B3LYP/6-31G** level of theory. It is shown that the first step is charge controlled; whereas the second one is controlled by frontier molecular orbitals. The H-1 and C-13 chemical shift values together with the structural parameters of the title compound have been also computed and the scaled values have been compared with the corresponding experimental NMR and X-ray spectra. As a result, the calculated spectroscopic data and optimized geometry show a good agreement with the experimental results. (C) 2012 Elsevier B.V. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 122-03-2. COA of Formula: https://www.ambeed.com/products/122-03-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, molecular formula is C8H6BrF3. In an article, author is Karnali, Fatemeh,once mentioned of 402-49-3, Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene.

In this work, the preparation and characterization of Fe3O4@SiO2-ZrCl2-MNPs as novel nano magnetic reagents is reported. After preparation, the promoting ability of this catalyst in the synthesis of tetrahydrobenzimidazo [2,1-b]quinazolin-1(2H)-ones and 2H-indazolo[2,1-b]phthalazine-triones is studied. The most important features of the present protocol are the easy preparation of the catalyst, mild reaction conditions, short reaction times, high yields and recyclability of the catalyst for at least four runs.

Interested yet? Keep reading other articles of 402-49-3, you can contact me at any time and look forward to more communication. Recommanded Product: 1-(Bromomethyl)-4-(trifluoromethyl)benzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 2215-77-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 2215-77-2, Name is 4-Phenoxybenzoic acid, SMILES is OC(=O)C1=CC=C(OC2=CC=CC=C2)C=C1, belongs to phthalazine compound. In a article, author is Guo, Tongxun, introduce new discover of the category.

Several Pd(II) complexes with unconventional pyridazine- and phthalazine-derived carbene ligands were synthesized via direct oxidative addition of Cl derivatives of the alkylated diazine heterocycles to Pd(0) species. The alkylated ligand precursors are readily prepared from commercial starting materials, and oxidative addition is regioselective. DFT calculations confirm that the thermodynamically favored products are formed. Four complexes (1-4) have been fully characterized, including by X-ray crystallography. Attractive intramolecular pi-pi stacking between the electron-poor N-alkylated diazine heterocycles and adjacent phenyl groups of the PPh3 coligands is revealed by the solid-state structures.

Electric Literature of 2215-77-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 2215-77-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Liu, Honglei, once mentioned the application of 7507-86-0, COA of Formula: https://www.ambeed.com/products/7507-86-0.html, Name is 2-Bromo-5-methoxybenzaldehyde, molecular formula is C8H7BrO2, molecular weight is 215.04, MDL number is MFCD00463817, category is phthalazine. Now introduce a scientific discovery about this category.

The Sc(OTf)(3)-catalyzed diastereoselective [3 + 3] cycloaddition of phthalazinium dicyanomethanides with cyclopropane 1,1-diesters proceeded smoothly under mild reaction conditions, affording a variety of 3,4-dihydro-1H-pyrido[2,1-a]phthalazine derivatives in up to 99% yields with excellent diastereoselectivities.

If you are interested in 7507-86-0, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/7507-86-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Reddy, M. Veeranaryana, once mentioned the application of 5267-64-1, Name is D-Penylalaninol, molecular formula is C9H13NO, molecular weight is 151.2056, MDL number is MFCD00064298, category is phthalazine. Now introduce a scientific discovery about this category, COA of Formula: https://www.ambeed.com/products/5267-64-1.html.

1H-Pyrazolo[1,2-6]phthalazine-5,10-dione carbonitriles and carboxylates possess a broad range of applications as active compounds in the pharmacological and biological fields. We developed an efficient and ecofriendly silica gel-supported tungstic acid (STA)-catalyzed one-pot synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione carbonitriles and carboxylates by a three-component reaction of an aldehyde, a malononitrile/ethyl cyanoacetate and a phthalhydrazide under solvent-free conditions. The major advantages of the present method are experimental simplicity, use of an inexpensive and ecofriendly reusable catalyst, good yields, and short reaction times. (C) 2014 Academie des sciences. Published by Elsevier Masson SAS. All rights reserved.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 5267-64-1, COA of Formula: https://www.ambeed.com/products/5267-64-1.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: phthalazines, 524-95-8, Name is 2-((Diphenylboryl)oxy)ethanamine, molecular formula is C14H16BNO, belongs to phthalazine compound. In a document, author is El-Helby, Abdel-Ghany A., introduce the new discover.

Novel series of phthalazine derivatives 6-11 were designed, synthesized, and evaluated for their anticancer activity against two human tumor cell lines, HCT-116 human colon adenocarcinoma and MCF-7 breast cancer cells, targeting the VEGFR-2 enzyme. Compounds 7a,b and 8b,c showed the highest anticancer activities against both HCT116 human colon adenocarcinoma cells with IC50 of 6.04 +/- 0.30, 13.22 +/- 0.22, 18 +/- 0.20, and 35 +/- 0.45M, respectively, and MCF-7 breast cancer cells with IC50 of 8.8 +/- 0.45, 17.9 +/- 0.50, 25.2 +/- 0.55, and 44.3 +/- 0.49M, respectively, in comparison to sorafenib as reference drug with IC50 of 5.47 +/- 0.3 and 7.26 +/- 0.3M, respectively. Eleven compounds in this series were further evaluated for their inhibitory activity against VEGFR-2, where compounds 7a, 7b, 8c, and 8b also showed the highest VEGFR-2 inhibition with IC50 of 0.11 +/- 0.01, 0.31 +/- 0.03, 0.72 +/- 0.08, and 0.91 +/- 0.08M, respectively, in comparison to sorafenib as reference ligand with IC50 of 0.1 +/- 0.02. Furthermore, molecular docking studies were performed for all synthesized compounds to predict their binding pattern and affinity towards the VEGFR-2 active site, in order to rationalize their anticancer activity in a qualitative way.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 524-95-8. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One-pot pseudo five-component synthesis of some new, vital and pharmaceutically important bis 1H-Indazolo [1,2-b]phthalazine-triones has been considered in presence of prepared NiFe2O4@TiO2-DEA-OSO3H nanostructure as an efficient magnetic nanocatalyst. The synthesized compounds can be good candidates to have diverse biological potency and efficacy. The geometry, electronic structure, natural bond orbitals (NBO) and molecular electrostatic potential (MEP) surface analysis were carried out for some bis 1H-Indazolo [1,2-b]phthalazine-triones using HF/3-21G computational method. The theoretical studies revealed the existense of intramoleculare hydrogen bonds and high HOMO-LUMO energy gap for the products structures. Some advantages of this protocol are high yields, short reaction times, simple purification, and environmentally mild reaction conditions. Furthermore, the catalyst was reused at least six times without substantial loss of catalytic activity. (C) 2019 Elsevier B.V. All rights reserved.

If you are hungry for even more, make sure to check my other article about 104-53-0, COA of Formula: https://www.ambeed.com/products/104-53-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Related Products of 198561-07-8, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 198561-07-8, Name is Fmoc-Pra-OH, SMILES is C#CC[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C(O)=O, belongs to phthalazine compound. In a article, author is Piryaei, Forozan, introduce new discover of the category.

The synthesis of 1H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione derivatives, using one-pot three-component condensation reaction of 3-nitrophthalic anhydride, hydrazine monohydrate, dimedone, and aromatic aldehydes in the presence of ZrO(NO3)(2).2H(2)O as the novel catalyst and in reflux conditions in EtOH was reported. Quantum theoretical calculations for three structures of compounds (5a, 5b, and 5c) were performed using the Hartree-Fock (HF) and density functional theory (DFT). From the optimized structure, geometric parameters were obtained and experimental measurements were compared with the calculated data. The structures of the products were confirmed by IR, H-1 NMR, C-13 NMR, mass spectra, and elemental analyses. The IR spectra data and H-1 NMR and C-13 NMR chemical shift computations of the 1H-indazolo[1,2-b]phthalazine-1,6,11(13H)-trione derivatives in the ground state were calculated. Frontier molecular orbitals (FMOs), total density of states (DOS), thermodynamic parameters, and molecular electrostatic potential (MEP) of the title compounds were investigated by theoretical calculations. Molecular properties such as the ionization potential (I), electron affinity (A), chemical hardness (eta), electronic chemical potential (mu), and electrophilicity (omega) were investigated for the structures. Thus, there was an excellent agreement between experimental and theoretical results.

Related Products of 198561-07-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 198561-07-8.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.89797-68-2, Name is 5-(Ethylthio)-1H-tetrazole, SMILES is CCSC1=NN=NN1, belongs to phthalazine compound. In a document, author is Kidwai, Mazaahir, introduce the new discover, COA of Formula: https://www.ambeed.com/products/89797-68-2.html.

A new green protocol has been developed for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones via one-pot, three-component condensation reaction of aromatic aldehydes with 1,3-dicarbonyl compounds and phthalhydrazide using reusable dodecylphosphonic acid (DPA) as heterogeneous solid acid catalyst under solvent-free conditions. This protocol provides a novel and improved method for obtaining 2H-indazolo[2,1-b]phthalazine-triones in terms of good yields with little catalyst loading. (C) 2012 Elsevier Ltd. All rights reserved.

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 89797-68-2. COA of Formula: https://www.ambeed.com/products/89797-68-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Application In Synthesis of p-Isopropylbenzenecarboxaldehyde, 122-03-2, Name is p-Isopropylbenzenecarboxaldehyde, SMILES is CC(C)C1=CC=C(C=O)C=C1, in an article , author is Wedek, Volker, once mentioned of 122-03-2.

The use of a new class of unsymmetrical cinchona-alkaloid-based, phthalazine-bridged organocatalysts enabled the highly enantioselective dichlorination of unfunctionalized alkenes. In combination with the electrophilic chlorinating agent 1,3-dichloro-5,5-dimethylhydantoin (DCDMH) and triethylsilyl chloride (TES-Cl) as the source of nucleophilic chloride, 1-aryl-2-alkyl alkenes were dichlorinated with enantioselectivities of up to 94:6 er. Initial mechanistic investigations suggest that no free chlorine is formed, and by replacement of the chloride by fluoride, enantioselective chlorofluorinations of alkenes are possible.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 122-03-2, you can contact me at any time and look forward to more communication. Application In Synthesis of p-Isopropylbenzenecarboxaldehyde.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem