Month: May 2021

Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals in a one-pot relay manner. In an article, author is Coelho, Catarina, once mentioned the application of 875-74-1, Name is H-D-Phg-OH, molecular formula is C8H9NO2, molecular weight is 151.16, MDL number is MFCD00008061, category is phthalazine. Now introduce a scientific discovery about this category, Safety of H-D-Phg-OH.

Aldehyde oxidase (AOX) is a xanthine oxidase (XO)-related enzyme with emerging importance due to its role in the metabolism of drugs and xenobiotics. We report the first crystal structures of human AOX1, substrate free (2.6-angstrom resolution) and in complex with the substrate phthalazine and the inhibitor thioridazine (2.7-angstrom resolution). Analysis of the protein active site combined with steady-state kinetic studies highlight the unique features, including binding and substrate orientation at the active site, that characterize human AOX1 as an important drug-metabolizing enzyme. Structural analysis of the complex with the noncompetitive inhibitor thioridazine revealed a new, unexpected and fully occupied inhibitor-binding site that is structurally conserved among mammalian AOXs and XO. The new structural insights into the catalytic and inhibition mechanisms of human AOX that we now report will be of great value for the rational analysis of clinical drug interactions involving inhibition of AOX1 and for the prediction and design of AOX-stable putative drugs.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application of 92-92-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 92-92-2, Name is [1,1′-Biphenyl]-4-carboxylic acid, SMILES is O=C(C1=CC=C(C2=CC=CC=C2)C=C1)O, belongs to phthalazine compound. In a article, author is Uno, Yasuhiro, introduce new discover of the category.

The cynomolgus macaque is a non-human primate species widely used in drug metabolism studies. Despite the importance of genetic polymorphisms in cytosolic aldehyde oxidase (AOX) 1 in humans, genetic variants have not been investigated in cynomolgus or rhesus macaques. Genetic variants in AOX1 were identified and allele frequencies were assessed using the genomes of 24 cynomolgus and 8 rhesus macaques. The analysis identified 38 non-synonymous variants, some of which were unique to cynomolgus macaques (bred in Cambodia, Indochina, or Indonesia) or rhesus macaques, whereas many variants were shared by the two lineages. Among the variants observed at relatively high frequencies, eight were selected for functional analysis. Recombinant P605L and V1338I AOX1 variants showed substantially lower phthalazine and carbazeran oxidation activities than the wild-type AOX1 protein. In liver cytosolic fractions from cynomolgus and rhesus macaques genotyped for P605L and V1338I AOX1, groups of cytosolic fractions with P605L and/or V1338I AOX1 variants showed significantly lower phthalazine and carbazeran oxidation activities than the wild type. These results indicate that AOX1 is polymorphic in cynomolgus and rhesus macaques, just as it is in humans. Further investigation is needed to reveal the functional significance of these AOX1 variants in drug metabolism.

Application of 92-92-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 92-92-2 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 1008-72-6, Name is Sodium 2-formylbenzenesulfonate, molecular formula is C7H5NaO4S, belongs to phthalazine compound, is a common compound. In a patnet, author is Sadimenko, Alexander P., once mentioned the new application about 1008-72-6, Recommanded Product: 1008-72-6.

Organometallic complexes of practically unsubstituted (non-chelating) azines and their benzannulated derivatives, possible N-heterocyclic carbenes containing at least one double bond, and boron-, boronenitrogen, silicon-, tri- and hexaphosphorus analogs of azines are considered in the view of their synthetic availability, coordination modes, and possible application in catalysis and materials chemistry.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 775-12-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 775-12-2, Name is Diphenylsilane, SMILES is C1([SiH2]C2=CC=CC=C2)=CC=CC=C1, belongs to phthalazine compound. In a article, author is Maheswari, Cinnathambi Subramani, introduce new discover of the category.

A new protocol for the synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives is described via a one-pot three-component condensation reaction of phthalhydrazide, dimedone or 1,3-cyclohexanedione and aromatic aldehydes catalyzed by SnO2 nanoparticles as a heterogeneous catalyst under solvent-free conditions. The SnO2 nanoparticles (NPs) were characterized by FT-IR, X-ray diffraction (XRD), field emission scanning electron microscopy (FE-SEM) and energy dispersive X-ray analyzer (EDAX). The advantages of the protocol are the shorter reaction time, simple work-up procedure and reusable catalyst. [GRAPHICS] .

Electric Literature of 775-12-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 775-12-2 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 83-53-4, Name is 1,4-Dibromonaphthalene. In a document, author is Tayebee, Reza, introducing its new discovery. Computed Properties of https://www.ambeed.com/products/83-53-4.html.

A novel Bronsted acidic ionic liquid 3-sulfonic acid 1-imidazolopyridinium hydrogen sulfate [Simp]HSO4 was synthesized via the reaction of caffeine with chlorosulfonic acid and was characterized by studying FT-IR, H-1 NMR, C-13 NMR, UV-Vis, and fluorescence spectra. Then, the prepared ionic liquid was utilized as an efficient catalyst for the preparation of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives through one-pot, multi-component condensation of aldehydes, phthalhydrazide, and dimedone under solvent free conditions. The high Bronsted acidic function of this catalyst originates principally from the dual hydrogen bonding abilities of the SO3H group. (C) 2015 Elsevier B.V. All rights reserved.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 83-53-4 help many people in the next few years. Computed Properties of https://www.ambeed.com/products/83-53-4.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, molecular formula is C7H6BrCl, belongs to phthalazine compound. In a document, author is Yuan, Chunhao, introduce the new discover, Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene.

The phosphine-catalyzed [3 + 2] cycloaddition between phthalazinium dicyanomethanides and allenoates, has been achieved in dichloromethane at room temperature, providing a broad range of novel heterocyclic compounds, 1,2,3,10b-tetrahydropyrrolo[2,1-a]phthalazine derivatives, as single (Z)-isomers in excellent yields (88-99% yield). All reactions are operationally simple and proceed very fast under mild reaction conditions.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 622-95-7. Application In Synthesis of 1-(Bromomethyl)-4-chlorobenzene.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.2128-93-0, Name is 4-Benzoylbiphenyl, SMILES is C1=CC(=CC=C1)C2=CC=C(C=C2)C(C3=CC=CC=C3)=O, belongs to phthalazine compound. In a document, author is Qin, Peiyong, introduce the new discover, Product Details of 2128-93-0.

In this study, propanedioic acid was investigated as a potential additive in poly(phthalazine ether sulfone ketone) (PPESK)/N-methyl-2-pyrrolidone solutions. Compared with poly(ethylene glycol) with a molecular weight of 1000 and Tween 80 as additives, different phenomena were observed: (1) both fingerlike and spongelike structures of asymmetric ultrafiltration membranes were induced by rapid gelation, and (2) a spongelike structure membrane with a high pure water flux was obtained under a high gelation rate. Moreover, the PPESK membrane formation process was recorded with a recently developed optical microscopy (OM)-charge-coupled device (CCD) camera experimental system. The predicted membrane structure with an OM-CCD system gave good correspondence with the final membrane structure and performance, as detected by scanning electron microscopy. (c) 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015, 132, 41621.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 2128-93-0 is helpful to your research. Product Details of 2128-93-0.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 80382-23-6, Catalysts allow a reaction to proceed via a pathway that has a lower activation energy than the uncatalyzed reaction. 80382-23-6, Name is Sodium 2-(4-((2-oxocyclopentyl)methyl)phenyl)propanoate, SMILES is CC(C1=CC=C(CC2C(CCC2)=O)C=C1)C([O-])=O.[Na+], belongs to phthalazine compound. In a article, author is El-Helby, Abdel-Ghany A., introduce new discover of the category.

Background: Extensive studies were reported in the synthesis of several phthalazine derivatives as promising anticancer agents as potent VEGFR-2 inhibitors. Vatalanib (PTK787) was the first anilinophthalazine published derivative as a potent inhibitor of VEGFR. The discovery of vatalanib as a clinical candidate led to the design and synthesis of different anilinophthalazine derivatives as potent inhibitors for VEGFR-2. The objective of present research work is the synthesis of new agents with the same essential pharmacophoric features of the reported and clinically used VEGFR-2 inhibitors (e.g vatalanib and sorafenib). The main core of our molecular design rationale comprised bioisosteric modification strategies of VEGFR-2 inhibitors at four different positions. Material and Methods: A correlation between structure and biological activity of our designed phthalazines was established using molecular docking and VEGFR-2 kinase assay. Results and Discussion: In view of their expected anticancer activity, novel triazolo[3,4-a]phthalazine derivatives 5-6a-o and 3-substituted-bis([1,2,41triazolo)[3,4-a:4′,3′-c]phthalazines 9a-b were designed, synthesized and evaluated for their anti-proliferative activity against two human tumor cell lines HCT-116 human colon adenocarcinoma and MCF-7 breast cancer. It was found that, compound 6o the most potent derivative against both HCT116 and MCF-7 cancer cell lines. Compounds 6o, 6m, 6d and 9b showed the highest anticancer activities against HCT116 human colon adenocarcinoma with IC50 of 7 +/- 0.06, 13 +/- 0.11, 15 +/- 0.14 and 23 +/- 0.22 mu M respectively while compounds 6o, 6d, 6a and 6n showed the highest anticancer activities against MCF-7 breast cancer with IC50 of 16.98 +/- 0.15, 18.2 +/- 0.17, 57.54 +/- 0.53 and 66.45 +/- 0.67 mu M respectively. Sorafenib as a highly potent VEGFR-2 inhibitor was used as a reference drug with IC50 of 5.47 +/- 0.3 and 7.26 +/- 0.3 mu M respectively. Nine compounds were further evaluated for their VEGFR-2 inhibitory activity. Compounds 6o, 6m, 6d and 9b emerged as the most active counterparts against VEGFR-2 with IC50 values of 0.1 +/- 0.01, 0.15 +/- 0.02, 0.28 +/- 0.03 and 0.38 +/- 0.04 mu M, respectively comparable to that of sorafenib (IC50 = 0.1+0.02) mu M. Furthermore, molecular docking studies were carried out for all synthesized compounds to investigate their binding pattern and predict their binding affinities towards VEGFR-2 active site. In silico ADMET studies were calculated for the tested compounds. Most of our designed compounds exhibited good ADMET profile. Conclusion: The obtained results showed that, the most active compounds could be useful as a template for future design, optimization, adaptation and investigation to produce more potent and selective VEGFR-2 inhibitors with higher anticancer analogs.

Reference of 80382-23-6, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 80382-23-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 556-08-1, Name is 4-Acetamidobenzoic acid, molecular formula is , belongs to phthalazine compound. In a document, author is Nejad, Fateme Khajoee, Name: 4-Acetamidobenzoic acid.

A tridentate Schiff base ligand, (E)-3-((2-hydroxy-3-methoxybenzylidene)amino)-2-methylquinazolin-4(3H)-one [HL], and its mixed-ligand Ni(II) complex [Ni(L)(imi)], were synthesized and fully characterized using elemental analysis, FT-IR, UV-Vis and (HNMR)-H-1 spectroscopy techniques. The structure of the synthesized ligand and complex was determined with single crystal X-ray diffraction method. In the complex, a square planner geometry was observed around the Ni(II) central atom coordinated with the donor atoms of the Schiff base ligand and one nitrogen of imidazole group. In addition, the catalytic activity of the complex on the three-component condensation of hydrazine hydrate with phthalic anhydride and dimedone to obtain 2H-indazolo[2,1-b]phthalazine-triones was investigated. Furthermore, in-vitro antimicrobial studies were performed that indicated the great antibacterial activities of the Ni(II) complex against Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus cereus bacteria.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Reference of 623-25-6, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 623-25-6, Name is α,α’-Dichloro-p-xylene, SMILES is ClCC1=CC=C(CCl)C=C1, belongs to phthalazine compound. In a article, author is Ziarani, Ghodsi Mohammadi, introduce new discover of the category.

A green protocol has been developed for the synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-diones by one-pot cyclocondensation reaction of phthalhydrazide, aromatic aldehydes, and malononitrile or ethyl cyanoacetate using sulfonic acid functionalized SBA-15 (SBA-Pr-SO3H) as a heterogeneous solid acid catalyst under solvent-free conditions.

Reference of 623-25-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 623-25-6 is helpful to your research.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem