4474-86-6, Name is N-Cbz-D-Asparagine, molecular formula is C12H14N2O5, belongs to phthalazine compound, is a common compound. In a patnet, author is Slawinski, Jaroslaw, once mentioned the new application about 4474-86-6, Recommanded Product: 4474-86-6.
Pathogenic fungi are one of the main causes of hospital-related infections. Since conventional antifungals have become less effective because of the increasing fungal resistance to the standard drugs, the need for new agents is becoming urgent. Herein we report a synthesis of a series of novel N-[imino-(1-oxo-(1H)-phthalazin-2-yl) methyl]benzenesulfonamide derivatives with in vitro activity against yeast-like fungi isolated from the oral cavity and respiratory tract of patients with candidiasis. These compounds were synthesized by the one-step or two-step reactions of 1-(2-alkylthiobenzensulfonyl)-2aminoguanidines with the appropriate ortho-carbonyl benzoic acids. The biological study revealed that new derivatives have shown significant growth-inhibitory activity, superior or comparable, than those of the reference drug fluconazole. The most promising activities were observed against Candida albicans, with inhibition at least 1-3 (12.5%-37.5%) of the eight tested strains at the low MIC level of <= 6.2-25 mu g/mL. We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4474-86-6. The above is the message from the blog manager. Recommanded Product: 4474-86-6.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem