Healthcare careers for chemists are once again largely based in laboratories, Electric Literature of 1571-08-0, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 1571-08-0, Name is Methyl 4-formylbenzoate, SMILES is C1=C(C(OC)=O)C=CC(=C1)C=O, belongs to phthalazine compound. In a document, author is Ma, Long-Xu, introduce the new discover.
Four series of [1,2,4]triazolo[3,4-a]phthalazine and tetrazolo[5,1-a]phthalazine derivatives bearing substituted piperazine moieties were synthesized and evaluated for their positive inotropic activity by measuring the left atrium stroke volume in isolated rabbit-heart preparations. Several compounds were developed and showed favorable activities compared to the standard drug milrinone, with (4-([1,2,4]triazolo[3,4-a]phthalazin-6-yl) piperazin-1-yl)(p-tolyl) methanone (5g) being identified as the most potent with an increased stroke volume of 19.15 +/- 0.22% (milrinone: 2.46 +/- 0.07%) at a concentration of 3 x 10(-5) M. A preliminary study of mechanism of action revealed that 5g displayed its positive inotropic effect may be related to the PDE-cAMP-PKA signaling pathway. Compounds exhibiting inotropic effects were also evaluated in terms of the chronotropic effects. (c) 2014 Elsevier Ltd. All rights reserved.
Electric Literature of 1571-08-0, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 1571-08-0 is helpful to your research.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem