Month: June 2021

In an article, author is Veisi, Hojat, once mentioned the application of 103-45-7, Recommanded Product: 103-45-7, Name is Phenethyl acetate, molecular formula is C10H12O2, molecular weight is 164.2, MDL number is MFCD00008720, category is phthalazine. Now introduce a scientific discovery about this category.

Phenyl sulfonic acid functionalized mesoporous SBA-15 silica (SBA-15-Ph-SO3H) was prepared through the silanization of activated mesoporous SBA-15 with diphenyldichlorosilane (DPCS) followed by silylation and sulfonation, and characterized by XRD, FT-IR, nitrogen adsorption analyses, BET theory and TEM. The sulfonic acid groups anchored to the silica surface of the pore walls were resistant to leaching in organic and aqueous solutions under mild conditions. This catalyst was found to be a recyclable heterogeneous catalyst for the rapid and efficient synthesis of various 2H-indazolo[2,1-b]phthalazine-triones and triazolo [1,2-a]indazole-triones. Also, this silylated mesoporous material containing phenylsulfonic acid groups has a greater stability of the sulfonic acid surface toward water than that of silica sulfuric acid (SSA) and sulfonated SBA-15.

If you are interested in 103-45-7, you can contact me at any time and look forward to more communication. Recommanded Product: 103-45-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is an experimental science, HPLC of Formula: https://www.ambeed.com/products/775-12-2.html, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 775-12-2, Name is Diphenylsilane, molecular formula is C12H12Si, belongs to phthalazine compound. In a document, author is Bakale, Raghavendra P..

An unusual tetrahedral mixed ligand Zn(II) complex ZnT(L)Cl, where L = 2-chlorobenzaldehyde hydralazine hydrazone and T = in situ generated 3-(2-chlorophenyl)-1,2,4-triazolo[3,4-a]phthalazine is reported. Structure of the fused triazole has been confirmed by single crystal X-ray diffraction studies. Structure of Co(II), Ni(II), Cu(II) and Zn(II) complexes has been confirmed by spectral and analytical methods. Metal complexes have exhibited better activity in the fructose induced hypertension studies in animal model and are comparable with the standard. (C) 2013 Elsevier Masson SAS. All rights reserved.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 775-12-2. HPLC of Formula: https://www.ambeed.com/products/775-12-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Thangadurai, T. Daniel, once mentioned the application of 789-25-3, SDS of cas: 789-25-3, Name is Triphenylsilane, molecular formula is C18H16Si, molecular weight is 260.4052, MDL number is MFCD00003003, category is phthalazine. Now introduce a scientific discovery about this category.

New hydrophilic fluorescent selective ion sensor based on phenazine and phthalazine moieties, 1,1′-(phenazine-2,3-diyl)-bis(3-(1,4-dihydroxyphthalazin-6-yl)urea) (1), has been designed, synthesized and characterized. Interestingly, sensor 1 exhibits prominent turn-on and turn-off’ fluorogenic signaling at 580 nm towards Fe2+ & AcO- and Sr2+ & Cu2+, respectively. The fluorescence titration experiments shed light on the nature of the interaction between 1 and guest molecules (Fe2+, Sr2+, Cu2+ and AcO-), which divulge that 1 is flexible enough to orient itself according to the size of the guest molecule. Water mediated excited-state intramolecular proton transfer (ESIPT) and photo-induced electron transfer (PET) mechanisms are responsible for the dual behavior of 1, which binds with guest molecules in 1:1 stoichiometry, Based on the significant duplex fluorescence response of 1, a molecular logic gate keypad lock with sixteen on passwords for a storage system has been developed. (C) 2018 Elsevier B.V. All rights reserved.

Interested yet? Read on for other articles about 789-25-3, you can contact me at any time and look forward to more communication. SDS of cas: 789-25-3.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds. 143-66-8, Name is Sodium tetraphenylborate, molecular formula is C24H20BNa, belongs to phthalazine compound, is a common compound. In a patnet, author is Bian, Ming, once mentioned the new application about 143-66-8, Recommanded Product: Sodium tetraphenylborate.

With the aim of finding new anticonvulsant drugs, new 6-substituted-[1,2,4] triazolo[3,4-a] (tetrazolo[5,1-a]) phthalazine derivatives (1-34) have been designed and synthesized. All the compounds were evaluated for their anticonvulsant activities using the maximal electroshock test (MES). Most of the synthesized compounds exhibited potent anticonvulsant activities in the MES. The most promising compound 14 showed significant anticonvulsant activity in MES test with ED50 value of 9.3 mg/kg. It displayed a wide margin of safety with protective index much higher than the standard drug Carbamazepine. And the potency of compound 14 against seizures induced by Pentylenetetrazole, Isoniazid, Thiosemicarbazide and 3-Mercaptopropionic acid in the chemical-induced seizure tests suggested that compound 14 displayed wide spectrum of activity in several models.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 143-66-8. The above is the message from the blog manager. Recommanded Product: Sodium tetraphenylborate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Xue, Deng-Qi, once mentioned the application of 1821-12-1, Category: phthalazines, Name is 4-Phenylbutanoic acid, molecular formula is C10H12O2, molecular weight is 164.2011, MDL number is MFCD00004403, category is phthalazine. Now introduce a scientific discovery about this category.

Trying to develop potent and selective anticancer agents, two series of novel 1,2,4-triazolo[3,4-a] phthalazine derivatives were designed and synthesized. Their antitumor activities were evaluated by MU method against four selected human cancer cell lines (MGC-803, EC-9706, HeLa and MCF-7). Our results showed that compound 11h exhibited good anticancer activities compared to 5-fluorouracil against the four tested cell lines, with IC50 values ranging from 2.0 to 4.5 mu M. Flow cytometry analysis indicated that compound 11h induced the cellular early apoptosis and cell cycle arrest at G2/M phase in EC-9706. (C) 2014 Published by Elsevier Masson SAS.

If you are interested in 1821-12-1, you can contact me at any time and look forward to more communication. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 2935-35-5, Name is H-Phg-OH, formurla is C8H9NO2. In a document, author is Lyu, Xue-Li, introducing its new discovery. Recommanded Product: 2935-35-5.

Herein we report a protocol for visible-light-induced copper-catalyzed decarboxylative coupling reactions between N-heteroarenes and redox-active esters. Various N-hydroxyphthalimide esters reacted with isoquinoline, quinoline, pyridine, pyrimidine, quinazoline, phthalazine, phenanthridine, and pyridazine to give the corresponding products in modest to excellent yields. The reactions proceed under mild conditions and have a broad scope and high functional group tolerance. Mechanistic studies revealed that the catalytic behavior of Cu-I photocatalyst generated in situ was consistent with that of preformed [Cu(dmp)(xantphos)]BF4.

If you are hungry for even more, make sure to check my other article about 2935-35-5, Recommanded Product: 2935-35-5.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Computed Properties of https://www.ambeed.com/products/618-88-2.html, 618-88-2, Name is 5-Nitroisophthalic acid, SMILES is O=C(O)C1=CC([N+]([O-])=O)=CC(C(O)=O)=C1, belongs to phthalazine compound. In a document, author is Mayakrishnan, Sivakalai, introduce the new discover.

Rhodium catalysed dehydrogenative C-H/N-H functionalization was developed to construct phthalazino[2,3-a]-/indazolo[1,2-a]cinnolines by reacting N-phenyl phthalazine/indazole with alkynes. The synthesized compounds exhibit prominent fluorescence properties in solid and aggregation states. Their application in cell imaging was investigated using various cancer cell lines.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 618-88-2. Computed Properties of https://www.ambeed.com/products/618-88-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , Category: phthalazines, 103-45-7, Name is Phenethyl acetate, molecular formula is C10H12O2, belongs to phthalazine compound. In a document, author is Ferreira, P., introduce the new discover.

Human aldehyde oxidase (hAOX1) is a molybdenum dependent enzyme that plays an important role in the metabolism of various compounds either endogenous or xenobiotics. Due to its promiscuity, hAOX1 plays a major role in the pharmacokinetics of many drugs and therefore has gathered a lot of attention from the scientific community and, particularly, from the pharmaceutical industry. In this work, homology modelling, molecular docking and molecular dynamics simulations were used to study the structure of the monomer and dimer of human AOX. The results with the monomer of hAOX1 allowed to shed some light on the role played by thioridazine and two malonate ions that are co-crystalized in the recent X-ray structure of hAOX1. The results show that these molecules endorse several conformational rearrangements in the binding pocket of the enzyme and these changes have an impact in the active site topology as well as in the stability of the substrate (phthalazine). The results show that the presence of both molecules open two gates located at the entrance of the binding pocket, from which results the flooding of the active site. They also endorse several modifications in the shape of the binding pocket (namely the position of Lys893) that, together with the presence of the solvent molecules, favour the release of the substrate to the solvent. Further insights were also obtained with the assembled homodimer of hAOX1. The allosteric inhibitor (THI) binds closely to the region where the dimerization of both monomers occur. These findings suggest that THI can interfere with protein dimerization.

If you are hungry for even more, make sure to check my other article about 103-45-7, Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. , HPLC of Formula: https://www.ambeed.com/products/482-05-3.html, 482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, molecular formula is C14H10O4, belongs to phthalazine compound. In a document, author is Sen, Supriti, introduce the new discover.

A systematic study of the reaction of 1,4-dihydrazinophthalazine (DHPH) with 1,3-dicarbonyls [viz., acetylacetone (acac), dibenzoylmethane (bzbz), and 1-benzoylacetone (bzac)] varying the reaction conditions was carried out to obtain the phthalazine derivatives (1-4). One-pot reaction of DHPH with acac led to the formation of two compounds 1 and 2, with various factors such as the presence of the acid or base, amount of the acac, time of reflux, and the temperature. The reaction conditions of DHPH with bzbz or bzac are sort of different to isolate the products 3 and 4, respectively. The derivatives (1-4) have been characterized by elemental analyses, H-1 NMR, and electrospray ionization-mass spectrometry (ESIMS) and the cytotoxic activity of the compounds 1-4 was evaluated on HeLa cell line. [Supplementary materials are available for this article. Go to the publisher’s online edition of Synthetic Communications (R) for the following free supplemental resource(s): Full experimental and spectral details.]

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 482-05-3. HPLC of Formula: https://www.ambeed.com/products/482-05-3.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Zaib, Sumera, once mentioned the application of 618-88-2, COA of Formula: https://www.ambeed.com/products/618-88-2.html, Name is 5-Nitroisophthalic acid, molecular formula is C8H5NO6, molecular weight is 211.13, MDL number is MFCD00007254, category is phthalazine. Now introduce a scientific discovery about this category.

Fused diaza-heterocycles constitute the core structure of numerous bioactive natural products and effective therapeutic drugs. Among them, phthalazines have been recognized as remarkable structural leads in medicinal chemistry due to their wide application in pharmaceutical and agrochemical industries. Accessing such challenging pharmaceutical agents/drug candidates with high chemical complexity through synthetically efficient approaches remains an attractive goal in the contemporary medicinal chemistry and drug discovery arena. In this review, we focus on the recent developments in the synthetic routes towards the generation of phthalazine-based active pharmaceutical ingredients and their biological potential against various targets. The general reaction scope of these innovative and easily accessible strategies was emphasized focusing on the functional group tolerance, substrate and coupling partner compatibility/limitation, the choice of catalyst, and product diversification. These processes were also accompanied by the mechanistic insights where deemed appropriate to demonstrate meaningful information. Moreover, the rapid examination of the structure-activity relationship analyses around the phthalazine core enabled by the pharmacophore replacement/integration revealed the generation of robust, efficient, and more selective compounds with pronounced biological effects. A large variety of in silico methods and ADME profiling tools were also employed to provide a global appraisal of the pharmacokinetics profile of diaza-heterocycles. Thus, the discovery of new structural leads offers the promise of improving treatments for various tropical diseases such as tuberculosis, leishmaniasis, malaria, Chagas disease, among many others including various cancers, atherosclerosis, HIV, inflammatory, and cardiovascular diseases. We hope this review would serve as an informative collection of structurally diverse molecules enabling the generation of mature, high-quality, and innovative routes to support the drug discovery endeavors.

If you are interested in 618-88-2, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/618-88-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem