Month: June 2021

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. COA of Formula: https://www.ambeed.com/products/81-48-1.html, 81-48-1, Name is 1-Hydroxy-4-(p-tolylamino)anthracene-9,10-dione, SMILES is O=C(C1=C2C=CC=C1)C3=C(NC4=CC=C(C)C=C4)C=CC(O)=C3C2=O, in an article , author is Majoumo-Mbe, Felicite, once mentioned of 81-48-1.

The title compound, C14H12N4S, was synthesized by the condensation reaction of hydralazine and 2-acetylthiophene and during the reaction, a proton transfer from the imino nitrogen atom to one of the endocylic nitrogen atoms occurred. The compound crystallizes in the monoclinic crystal system with two independent molecules (molecules 1 and 2) in the asymmetric unit. In each molecule, there is a slight difference in the orientation of the thiophene ring with respect to phthalazine ring system, molecule 1 showing a dihedral angle of 42.51 (1)degrees compared to 8.48 (1)degrees in molecule 2. This implies an r.m.s deviation of 0.428 (1) angstrom between the two molecules for the 19 non-H atoms. The two independent molecules are connected via two N-H center dot center dot center dot N hydrogen bonds, forming dimers which interact by two bifurcated pi-pi stacking interactions to build tetrameric motifs. The latter are packed in the ac plane via weak C-H center dot center dot center dot pi interactions and along the b axis via C-H center dot center dot center dot N and C-H center dot center dot center dot pi interactions. This results a three-dimensional architecture with a tilted herringbone packing mode.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 81-48-1, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/81-48-1.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Zhang Haiming, once mentioned the application of 122-03-2, Name: p-Isopropylbenzenecarboxaldehyde, Name is p-Isopropylbenzenecarboxaldehyde, molecular formula is C10H12O, molecular weight is 148.2017, MDL number is MFCD00006953, category is phthalazine. Now introduce a scientific discovery about this category.

Four series of derivatives, 6-substituted-1,2,4-triazolo[3,4-a] phthalazine derivatives and 6-substituted tetrazolo[5,1-a] phthalazine derivatives have been synthesized. The structures of compounds are confirmed by H-1 NMR, C-13 NMR, IR and HRMS. The anticonvulsant effects of the compounds are evaluated with maximal electroshock test by intraperitoneally injected in mice. The experimental results show that N-(4-bromophenyl) tetrazolo[5,1-alpha]phthalazin-6-amine (7a) was the most potent compound, with a median effective dose of 5.89 mg circle kg(-1). Its anticonvulsant effect is better than the reference drug, carbamazepine.

If you are interested in 122-03-2, you can contact me at any time and look forward to more communication. Name: p-Isopropylbenzenecarboxaldehyde.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4474-86-6, Name is N-Cbz-D-Asparagine, molecular formula is C12H14N2O5. In an article, author is Reilly, Sean W.,once mentioned of 4474-86-6, Safety of N-Cbz-D-Asparagine.

Development of poly(ADP-ribose) polymerase inhibitors (PARPi’s) continues to be an attractive area of research due to synthetic lethality in DNA repair deficient cancers; however, PARPi’s also have potential as therapeutics to prevent harmful inflammation. We investigated the pharmacological impact of incorporating spirodiamine motifs into the phthalazine architecture of FDA approved PARPi olaparib. Synthesized analogues were screened for PARP-1 affinity, enzyme specificity, catalytic inhibition, DNA damage, and cytotoxicity. This work led to the identification of 10e (12.6 +/- 1.1 nM), which did not induce DNA damage at similar drug concentrations as olaparib. Interestingly, several worst in class compounds with low PARP-1 affinity, including 15b (4397 +/- 1.1 nM), induced DNA damage at micromolar concentrations, which can explain the cytotoxicity observed in vitro. This work provides further evidence that high affinity PARPi’s can be developed without DNA damaging properties offering potential new drugs for treating inflammatory related diseases.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry, like all the natural sciences, begins with the direct observation of nature— in this case, of matter.88-44-8, Name is 4-Aminotoluene-3-sulfonic acid, SMILES is O=S(C1=CC(C)=CC=C1N)(O)=O, belongs to phthalazine compound. In a document, author is Reddy, Mudumala Veeranarayana, introduce the new discover, Quality Control of 4-Aminotoluene-3-sulfonic acid.

An efficient, rapid, and green synthesis of 2H-indazolo[2,1-b]phthalazine-triones has been accomplished under solvent-free conditions by the reaction of phthalhydrazide, aldehydes and 5,5-dimethylcyclohexane-1,3-dione. This approach exploits the synthetic potential of microwave irradiation and Montmorillonite K-10 combination and offers many advantages, such as excellent product yields, shorter reaction time, reusable catalyst, easy isolation of products, and environmentally benign reaction conditions. (C) 2012 Elsevier Ltd. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 88-44-8 is helpful to your research. Quality Control of 4-Aminotoluene-3-sulfonic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Kumar, P. Sagar Vijay, once mentioned the application of 1603-79-8, Name is Ethyl benzoylformate, molecular formula is C10H10O3, molecular weight is 178.1846, MDL number is MFCD00009120, category is phthalazine. Now introduce a scientific discovery about this category, Recommanded Product: Ethyl benzoylformate.

A series of novel chromeno-pyrazolo[1,2-b] phthalazine-6,9,14(7H)-trione derivatives (4a-k) were designed and prepared using a reusable and efficient catalyst ionic liquid [Bmim] BF4 via one-pot multi-component reaction. Their bioactivity was evaluated against Aspergillus niger and Candida albicans in vitro. Compound 4f was found to be the most effective compared to all other synthesised compounds. To validate experimental biological data obtained, molecular docking study was carried out. It was observed that compound 4f showed stronger binding interactions with secreted aspartic proteinase (SAP) of C. albicans (1EAG). Further, primary optimisation of drug-like properties was studied through in silico predictions by using ADMET predictor FAF-drug2 and OSIRIS property explorer. (C) 2015 King Saud University. Production and hosting by Elsevier B.V.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In an article, author is Dabiri, Minoo, once mentioned the application of 1821-12-1, Application In Synthesis of 4-Phenylbutanoic acid, Name is 4-Phenylbutanoic acid, molecular formula is C10H12O2, molecular weight is 164.2011, MDL number is MFCD00004403, category is phthalazine. Now introduce a scientific discovery about this category.

(1,2,3-Triazol-4-yl)methyl-3-amino-5,10-dihydro-5,10-dioxo-1H-pyrazolo[1,2-b]phthalazine-2-carboxylate derivatives were synthesized by a four-component, one-pot condensation reaction of benzaldehyde derivatives, an active methylene compound (prop-2-ynyl-2-cyanoacetate), azides, and phthalhydrazide in the presence of Cu(OAc)(2)/sodium ascorbate as catalysts and 1-methyl-1H-imidazolium trifluoroacetate ([Hmim]TFA) as an ionic liquid medium in good to excellent yields.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 1078-61-1, Name is 3-(3,4-Dihydroxyphenyl)propionic acid, SMILES is O=C(O)CCC1=CC=C(O)C(O)=C1, in an article , author is Bodman, Samantha E., once mentioned of 1078-61-1, Formula: https://www.ambeed.com/products/1078-61-1.html.

The reaction of ligands based on 3,6-di(2-pyridyl)pyridazine with symmetrical carbocyclic rings fused to the pyridazine ring; 7,10-di(2-pyridyl)-8,9-diazafluoranthene (L-1), 1,4-di(2-pyridyl)-6,7,8,9-tetrahydro-5H-cyclo-hepta[d]pyridazine (L-2), 1,4-di(2-pyridyl)-5,6,7,8-tetrahydro-phthalazine (L-3), 1,4-di(2-pyridyl)-6,7-dihydro-5H-cyclo-penta[d]pyridazine (L-4) with silver salts gave a series of complexes (1-7). Characterisation of these using single crystal X-ray structure determination clearly showed that the steric bulk of the carbocycle affects the degree to which pyridine groups remain co-planar with pyridizine, and hence their ability to chelate. The more hindered ligands L-1-L-3 form a mixture of bischelating and tetrabridging, while the least hindered (L-4) was able to chelate exclusively. In the case of L-4, the nature of the anion and solvent were also able to affect the outcome of the reaction, with tetrafluoroborate giving the first example of a 4,5-substituted 3,6-di(2-pyridyl) pyridazine ring forming a [2 x 2]-grid.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 608141-42-0, Name is (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine. In a document, author is Azarifar, Davood, introducing its new discovery. Name: (S)-1-(3-Ethoxy-4-methoxyphenyl)-2-(methylsulfonyl)ethanamine.

Tetrakis(acetonitrile) copper(I) hexafluorophosphate, [Cu(CH3CN)(4)]PF6, was explored as an efficient catalyst to promote the three-component reaction of aryl aldehydes, dimedone and urazole or phthalhydrazide to afford the corresponding triazolo[1,2-a]indazole-1,3,8-trione and 2H-indazolo[2,1-b]phthalazine-trione derivatives respectively in high yields. The reactions were conducted at 80-100 degrees C under solvent-free conditions. The catalyst was easily prepared from available and inexpensive materials and was quantitatively recovered from the reaction by simple filtration and reused for a number of cycles with almost consistent activity.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Electric Literature of 89797-68-2, The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 89797-68-2, Name is 5-(Ethylthio)-1H-tetrazole, SMILES is CCSC1=NN=NN1, belongs to phthalazine compound. In a article, author is Esmaeilpour, Mohsen, introduce new discover of the category.

In this paper, we adopt a facile method to prepare a type of porous silica nanoparticles (n-SiO2) from tetraethyl orthosilicate as the source of silica. Then, dendritic polymer supported on nanosilica with surface amino groups was fabricated. Finally, H3PW12O40 nanoparticles (PWA(n)) were synthesized by the treatment of H3PW12O40 powder with n-Octane as solvent by a solvothermal method and then immobilized onto the dendrimer polymer functionalized nanosilica. The synthesized nanostructures were characterized by fourier transform infrared (FT-IR), X-ray diffraction (XRD), thermogravimetric analysis (TGA), dynamic light scattering (DLS), N-2 adsorption-desorption isotherm analysis, UV-Vis and elemental analysis. The morphology of the catalyst was characterized using transmission electron microscopes (TEM). The acidity of the catalyst was determined by FTIR pyridine adsorption spectroscopy. Then, this catalytic system was used as an efficient catalyst for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones via multi-component and one-pot reactions of various aldehydes, phthalic anhydride, hydrazinium hydroxide, and dimedone under thermal solvent-free conditions or ultrasound irradiation at room temperature. Also, the catalyst can be easily recovered and reused for six consecutive reaction cycles without significant loss of activity.

Electric Literature of 89797-68-2, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 89797-68-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. 838-88-0, Name is 4,4′-Methylenebis(2-methylaniline), SMILES is NC1=CC=C(CC2=CC=C(C(C)=C2)N)C=C1C, in an article , author is Goli-Jolodar, Omid, once mentioned of 838-88-0, Recommanded Product: 4,4′-Methylenebis(2-methylaniline).

In this research work, 4,4′-(butane-1,4-diyl) bis(1-sulfo-1,4-diazabicyclo[2.2.2]octane-1,4-diium) tetrachloride (NS-C4(DABCO-SO3H)(2)center dot 4Cl) as a new nano-sized N-sulfonic acid was prepared and characterized using different types of spectroscopic methods including FT-IR, H-1 NMR, C-13 NMR, XRD, TGA and SEM analysis. This new reagent was efficiently used as catalyst for the promotion of the one-pot synthesis of 2H-indazolo[2,1-b] phthalazine-1,6,11(13H)-triones derivatives, as a class of biologically active compounds with important pharmaceutical properties, under solvent-free conditions during short reaction times in high yields.

Interested yet? Read on for other articles about 838-88-0, you can contact me at any time and look forward to more communication. Recommanded Product: 4,4′-Methylenebis(2-methylaniline).

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem