The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. In an article, author is Slawinski, Jaroslaw, once mentioned the application of 4474-86-6, Name is N-Cbz-D-Asparagine, molecular formula is C12H14N2O5, molecular weight is 266.25, MDL number is MFCD00065696, category is phthalazine. Now introduce a scientific discovery about this category, Name: N-Cbz-D-Asparagine.
Pathogenic fungi are one of the main causes of hospital-related infections. Since conventional antifungals have become less effective because of the increasing fungal resistance to the standard drugs, the need for new agents is becoming urgent. Herein we report a synthesis of a series of novel N-[imino-(1-oxo-(1H)-phthalazin-2-yl) methyl]benzenesulfonamide derivatives with in vitro activity against yeast-like fungi isolated from the oral cavity and respiratory tract of patients with candidiasis. These compounds were synthesized by the one-step or two-step reactions of 1-(2-alkylthiobenzensulfonyl)-2aminoguanidines with the appropriate ortho-carbonyl benzoic acids. The biological study revealed that new derivatives have shown significant growth-inhibitory activity, superior or comparable, than those of the reference drug fluconazole. The most promising activities were observed against Candida albicans, with inhibition at least 1-3 (12.5%-37.5%) of the eight tested strains at the low MIC level of <= 6.2-25 mu g/mL. We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4474-86-6. The above is the message from the blog manager. Name: N-Cbz-D-Asparagine.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem