Healthcare careers for chemists are once again largely based in laboratories, Related Products of 789-25-3, although increasingly there is opportunity to work at the point of care, helping with patient investigation. 789-25-3, Name is Triphenylsilane, SMILES is [SiH](C1=CC=CC=C1)(C2=CC=CC=C2)C3=CC=CC=C3, belongs to phthalazine compound. In a document, author is Kumar, P. Sagar Vijay, introduce the new discover.
A series of novel chromeno-pyrazolo[1,2-b] phthalazine-6,9,14(7H)-trione derivatives (4a-k) were designed and prepared using a reusable and efficient catalyst ionic liquid [Bmim] BF4 via one-pot multi-component reaction. Their bioactivity was evaluated against Aspergillus niger and Candida albicans in vitro. Compound 4f was found to be the most effective compared to all other synthesised compounds. To validate experimental biological data obtained, molecular docking study was carried out. It was observed that compound 4f showed stronger binding interactions with secreted aspartic proteinase (SAP) of C. albicans (1EAG). Further, primary optimisation of drug-like properties was studied through in silico predictions by using ADMET predictor FAF-drug2 and OSIRIS property explorer. (C) 2015 King Saud University. Production and hosting by Elsevier B.V.
Related Products of 789-25-3, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 789-25-3.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem