Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Recommanded Product: 622-88-8, 622-88-8, Name is (4-Bromophenyl)hydrazine hydrochloride, molecular formula is C6H8BrClN2, belongs to phthalazine compound. In a document, author is Wei, Cheng-Xi, introduce the new discover.
In a previous research, we synthesized and evaluated the anticonvulsant activity of a series of 6-substituted-oxy-[1,2,4] triazolo[3,4-a] phthalazine compounds. Reference to other studies, we deduce that the compounds may be useful for regulating inotropic activity by effecting stroke volume, so in this study, we evaluated 20 compounds (15a-t) for their changed inotropic activity by measuring the left atrium stroke volume in heart preparations isolated from Wistar rats. Among the 20 compounds, 15j was the most potent with an increased stroke volume of 27.39 +/- 3.16 % at the concentration of 50 mu M, compound 15m was identified as the most potent with an decreased stroke volume of -95.59 +/- 0.50 % at the same concentration which is much more effective than referenced drug Nifedipine (-55.22 +/- 1.87% at the concentration of 1 mu M).
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem