Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 402-49-3, Name is 1-(Bromomethyl)-4-(trifluoromethyl)benzene, molecular formula is , belongs to phthalazine compound. In a document, author is Zhang Luye, Application of 402-49-3.
In order to find more efficient and low toxicity antitumor drugs, a series of novel 1,3-disubstituted pyridazinone derivatives were synthesized and evaluated for their antiproliferative activities against four human cancer cell lines (MCF-7, PC-3, SW-620 and HGC-27) in vitro. The results showed that most compounds had good antiproliferative activities, especially 2-(4-(4-bromophenyl)-1-oxo-tolylazine-2(1H)-yl)-N-(2-fluorophenyl)acetamide (5g) exhibited better antiproliferative activities with IC50 value of 6.01 mu mol/L. In a nutshell, this work provided clues to discover antitumor agent based on the quinazoline scaffold.
Synthetic Route of 402-49-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 402-49-3.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem