Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, creation and manufacturing process of chemical products and materials. Recommanded Product: 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, 54381-16-7, Name is 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate, SMILES is NC1=CC=C(N(CCO)CCO)C=C1.O=S(O)(O)=O, in an article , author is Abdel-Aziz, Hatem A., once mentioned of 54381-16-7.
In continuation of our endeavor with respect to the development of potent and effective isatin-based anticancer agents, we adopted the molecular hybridization approach to design and synthesize four different sets of isatin-quinazoline (6a-f and 7a-e)/phthalazine (8a-f)/quinoxaline (9a-f) hybrids. The antiproliferative activity of the target hybrids was assessed towards HT-29 (colon), ZR-75 (breast) and A-549 (lung) human cancer cell lines. Hybrids 8b-d emerged as the most active antiproliferative congener in this study. Compound 8c induced apoptosis via increasing caspase 3/7 activity by about 5-fold in the A-549 human cancer cell line. In addition, it exhibited an increase in the G1 phase and a decrease in the S and G2/M phases in the cell cycle effect assay. Furthermore, it displayed an inhibitory concentration 50% value of 9.5 mu M against multidrug-resistant NCI-H69AR lung cancer cell line. The hybrid 8c was also subjected to in vitro metabolic investigations through its incubation with rat liver microsomes and analysis of the resulting metabolites with the aid of liquid chromatography-mass spectrometry.
Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 54381-16-7. Recommanded Product: 2,2′-((4-Aminophenyl)azanediyl)diethanol sulfate.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem