Application of 81-16-3, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, belongs to phthalazine compound. In a article, author is Wei, Cheng-Xi, introduce new discover of the category.
In a previous research, we synthesized and evaluated the anticonvulsant activity of a series of 6-substituted-oxy-[1,2,4] triazolo[3,4-a] phthalazine compounds. Reference to other studies, we deduce that the compounds may be useful for regulating inotropic activity by effecting stroke volume, so in this study, we evaluated 20 compounds (15a-t) for their changed inotropic activity by measuring the left atrium stroke volume in heart preparations isolated from Wistar rats. Among the 20 compounds, 15j was the most potent with an increased stroke volume of 27.39 +/- 3.16 % at the concentration of 50 mu M, compound 15m was identified as the most potent with an decreased stroke volume of -95.59 +/- 0.50 % at the same concentration which is much more effective than referenced drug Nifedipine (-55.22 +/- 1.87% at the concentration of 1 mu M).
Application of 81-16-3, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. I hope my blog about 81-16-3 is helpful to your research.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem