Month: July 2021

Having gained chemical understanding at molecular level, chemistry graduates may choose to apply this knowledge in almost unlimited ways, as it can be used to analyze all matter and therefore our entire environment., Name: 2-Hydroxy-2-phenylacetic acid, 90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, SMILES is C1=CC=CC=C1C(C(O)=O)O, belongs to phthalazine compound. In a document, author is Iravani, Nasir, introduce the new discover.

A novel heteropolyanion-based Bronsted acidic ionic liquid material [PhBS](3)PW12O40, butane mono-sulfoacid-functionalized phenanthrolinum salt of phosphortungstate catalyst (PhBS-PW), was synthesized and well characterized with FTIR, H-1 and C-13 NMR, electro-spray ionization mass spectrometry (ESI-MS), EDX and TG analysis techniques. The new prepared catalyst was used for the efficient one-pot synthesis of 2H-indazolo[2,1-b]phthalazine-trione derivatives from a three-component condensation reaction between aromatic aldehydes, dimedone, and phthalhydrazide in H2O under thermal conditions. This green approach has several advantages such as short reaction times, clean reaction profiles, and simple experimental and workup procedures. Moreover, the catalyst can be easily recovered and reused at least nine times with only slight reduction in its catalytic activity with no leaching amount of catalyst into the reaction mixture. These economical factors (time, cost, waste, etc.) for this three-component reaction hold promise for the future of organic synthesis. Graphic abstract In this work we introduced a new efficient Bronsted acidic ionic liquid (BAIL) and then its catalytic activities have been considered in the three-component synthesis of 2H-indazolo[2,1-b]phthalazine-triones via the domino Knoevenagel condensation/Michael addition/intramolecular cyclodehydration sequence in water under reflux condition. [GRAPHICS] .

If you are hungry for even more, make sure to check my other article about 90-64-2, Name: 2-Hydroxy-2-phenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: https://www.ambeed.com/products/1603-79-8.html, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 1603-79-8, Name is Ethyl benzoylformate, SMILES is CCOC(=O)C(=O)C1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Li, Junbo, introduce new discover of the category.

Three novel diazatwistpentacenes (1,4,6,13-tetraphenyl-7:8,11:12-bisbenzo-2,3-diazatwistpentacene (1, IUPAC name: 9,11,14,16-tetraphenyl-1,6-dihydrobenzo [8,9] triphenyleno[2,3-g]phthalazine); 1,4-di(pyridin-2-yl)-6,13-diphenyl-7:8,11:12-bisbenzo-2,3-diazatwistpentacene (2, IUPAC name: 9,16-diphenyl-11,14-di(pyridin-2-yl)-1,6-dihydrobenzo[8,9]triphenyleno[2,3-g]phthalazine); and 1,4-di(thien-2-yl)-6,13-diphenyl-7:8,11:12-bisbenzo-2,3-diazatwistpentacene (3, IUPAC name: 9,16-dipheny1-11,14-di (thien-2-y1)-1,6-dihydrobenzo [8,9] triphenyleno[2,3-g]phthalazine)) have been successfully synthesized through [4 + 2] cycloaddition reaction involving in situ arynes as dienophiles and substituted 1,2,4,5-tetrazines as dienes. Their structures have been determined by single-crystal X-ray diffraction, confirming that all compounds have twisted configurations with torsion angles between the pyrene unit and the 2,3-diazaanthrance part as high as 21.52 degrees (for 1), 24.74 degrees (for 2), and 21.14 degrees (for 3). The optical bandgaps for all compounds corroborate the values derived from CV. The calculation done by DFT shows that the HOMO-LUMO bandgaps are in good agreement with experimental data. Interestingly, the substituted groups (phenyl, pyridyl, thienyl) in the 1,4-positions did affect their self-assembly and the optical properties of as-resulted nanostructures. Under the same conditions, compounds 1-3 could self-assemble into different morphologies such as microrods (for 1), nanoprisms (for 2), and nanobelts (for 3). Moreover, the UV-vis absorption and emission spectra of as-prepared nanostructures were largely red-shifted, indicating J-type aggregation for all materials. Surprisingly, both 1 and 2 showed aggregation-induced emission (ALE) effect, while compound 3 showed aggregation-caused quenching (ACQ) effect. Our method to approach novel twisted azaacenes through [4 + 2] reaction could offer a new tool to develop unusual twisted conjugated materials for future optoelectronic applications.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1603-79-8. COA of Formula: https://www.ambeed.com/products/1603-79-8.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 2-Oxo-2-phenylacetic acid, While the job of a research scientist varies, most chemistry careers in research are based in laboratories, where research is conducted by teams following scientific methods and standards. 611-73-4, Name is 2-Oxo-2-phenylacetic acid, SMILES is O=C(O)C(C1=CC=CC=C1)=O, belongs to phthalazine compound. In a article, author is Reilly, Sean W., introduce new discover of the category.

Development of poly(ADP-ribose) polymerase inhibitors (PARPi’s) continues to be an attractive area of research due to synthetic lethality in DNA repair deficient cancers; however, PARPi’s also have potential as therapeutics to prevent harmful inflammation. We investigated the pharmacological impact of incorporating spirodiamine motifs into the phthalazine architecture of FDA approved PARPi olaparib. Synthesized analogues were screened for PARP-1 affinity, enzyme specificity, catalytic inhibition, DNA damage, and cytotoxicity. This work led to the identification of 10e (12.6 +/- 1.1 nM), which did not induce DNA damage at similar drug concentrations as olaparib. Interestingly, several worst in class compounds with low PARP-1 affinity, including 15b (4397 +/- 1.1 nM), induced DNA damage at micromolar concentrations, which can explain the cytotoxicity observed in vitro. This work provides further evidence that high affinity PARPi’s can be developed without DNA damaging properties offering potential new drugs for treating inflammatory related diseases.

If you are hungry for even more, make sure to check my other article about 611-73-4, Recommanded Product: 2-Oxo-2-phenylacetic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 371-42-6, Name is 4-Fluorothiophenol, molecular formula is C6H5FS, belongs to phthalazine compound. In a document, author is Soheilizad, Mehdi, introduce the new discover, SDS of cas: 371-42-6.

An efficient and simple method for the synthesis of aliphatic and aromatic 1H-indazolo[2,1-b]phthalazinetrione derivatives through a one-pot three-component condensation of phthalhydrazide, aldehyde, and dimedone in the presence of boron sulfonic acid as a reusable and efficient catalyst under solvent-free conditions is described. The reusability of catalyst, good to excellent yields, short reaction times, and the avoidance of harsh reagents are the main advantages of this method. .

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 371-42-6, SDS of cas: 371-42-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 622-95-7, As a society publisher, everything we do is to support the scientific community – so you can trust us to always act in your best interests, and get your work the international recognition that it deserves. 622-95-7, Name is 1-(Bromomethyl)-4-chlorobenzene, SMILES is ClC1=CC=C(CBr)C=C1, belongs to phthalazine compound. In a article, author is Raghuvanshi, Dushyant Singh, introduce new discover of the category.

A high yielding and environmentally benign synthesis of 2H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione derivatives has been achieved using silica-supported KHSO4 catalyst under solvent-free conditions. The methodology adopted is simple, versatile and requires no column chromatography.

If you’re interested in learning more about 622-95-7. The above is the message from the blog manager. SDS of cas: 622-95-7.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: https://www.ambeed.com/products/1571-08-0.html, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 1571-08-0, Name is Methyl 4-formylbenzoate, SMILES is C1=C(C(OC)=O)C=CC(=C1)C=O, belongs to phthalazine compound. In a article, author is Etinski, Mihajlo, introduce new discover of the category.

Quinazoline, quinoxaline and phthalazine are nitrogen containing heterocyclic aromatic molecules which belong to the class diazanaphthalenes. These isomers have low-lying n pi(star) and naphthalene-like pi pi(star) states that interact via spin-orbit coupling. In this contribution, we study their structure and electronic states by means of a coupled-cluster method. The computed properties are compared to those of cinnoline which were obtained in our previous study [Etinski et al., Phys. Chem. Chem. Phys., 2014, 16, 4740]. The excited state features of these isomers are dependent on the position of the nitrogen atoms. We find that quinazoline and quinoxaline exhibit similarities in the ordering and character of the excited states. In contrast, a marked difference in the electronic and geometric structures of the lowest excited triplet states of cinnoline and phthalazine is noticed, although both are orthodiazanaphthalenes. Our findings suggest that the S-1 (sic) T-1 channel is responsible for the rapid intersystem crossing in quinazoline and quinoxaline, whereas the S-1 (sic) T-2 pathway is active in phthalazine.

If you are interested in 1571-08-0, you can contact me at any time and look forward to more communication. COA of Formula: https://www.ambeed.com/products/1571-08-0.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Name: Dicyclohexylamine (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoate, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 62965-37-1, Name is Dicyclohexylamine (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoate, SMILES is C1CCC(CC1)NC1CCCCC1.[H][C@@](NC(=O)OCC1=CC=CC=C1)(C(O)=O)C(C)(C)C, belongs to phthalazine compound. In a article, author is Jalili-Baleh, Leili, introduce new discover of the category.

A novel series of tacrine-like compounds 7a-u possessing a fused pyrazolo[1,2-b]phthalazine structure were designed and synthesized as potent and selective inhibitors of AChE. The in-vitro biological assessments demonstrated that several compounds had high anti-AChE activity at nano-molar level. The more promising compound 71 with IC50 of 49 nM was 7-fold more potent than tacrine and unlike tacrine, it was highly selective against AChE over BuChE. The cell-based assays against hepatocytes (HepG2) and neuronal cell line (PC12) revealed that 71 had significantly lower hepatotoxicity compared to tacrine, with additional neuroprotective activity against H2O2-induced damage in PC12 cells. This compound could also inhibit AChE-induced and self-induced A beta peptide aggregation. The advantages including synthetic accessibility, high potency and selectivity, low toxicity, adjunctive neuroprotective and A beta aggregation inhibitory activity, make this compound as a new multifunctional lead for Alzheimer’s disease drug discovery. (C) 2017 Elsevier Masson SAS. All rights reserved.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 62965-37-1. Name: Dicyclohexylamine (S)-2-(((benzyloxy)carbonyl)amino)-3,3-dimethylbutanoate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Redox catalysis has been broadly utilized in electrochemical synthesis due to its kinetic advantages over direct electrolysis. 2215-77-2, Name is 4-Phenoxybenzoic acid, molecular formula is , belongs to phthalazine compound. In a document, author is El-Gazzar, Marwa G., Product Details of 2215-77-2.

Aims and Objective: A series of novel phthalazine derivatives was synthesized with versatile, readily accessible electrophilic and nucleophilic reagents. The newly synthesized compounds were confirmed by the results of spectroscopic measurements. Hence, their potential clinical application investigated in particular for cancer treatment. Materials and Methods: The newly synthesized compounds were characterized by spectroscopic measurements and were tested for their in vitro anticancer activity by MTT assay against human liver cancer cell line. Docking study of all the synthesized compounds was performed within the active site of the enzyme VEGFR-2 (Vascular Endothelial Growth Factor Receptor-2). Results: The quinazoline derivative 12 emerged as the most potent compound in this study with an IC50 value of 5.4 mu M. Docking study showed that the synthesized compounds were fit in the VEGFR-2 active site almost at the same position of sorafenib and vatalanib with comparable docking scores (-15.20 to -8.92 was kcal/mol). Conclusion: we have synthesized a novel series of phthalazine derivatives and evaluated their potential anticancer activity against HEPG2 cell line. The quinazoline derivative 12 emerged as the most potent compound in this study with an IC50 value of 5.4 mu M. The SAR and docking studies pointed out that rigidification of the structure resulted in better activity and better binding within the active site of VEGFR-2 as in compounds 3, 5, 6 and 12. These results introduced new phthalazine derivatives having promising activity which could lead to the development of more potent anticancer agents.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 2215-77-2. Product Details of 2215-77-2.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 36809-26-4, Name is (4-Bromophenyl)diphenylamine, molecular formula is C18H14BrN, belongs to phthalazine compound. In a document, author is Behalo, Mohamed S., introduce the new discover, Category: phthalazines.

A new series of phthalazine derivatives was synthesized from the reaction of 1-chloro-4-(4-phenoxyphenyl)phthalazine as a reactive starting material with different carbon, nitrogen, oxygen, and sulfur nucleophiles. The structural formulae of all products were confirmed and characterized by elemental analyses and spectral data (IR, H-1 NMR, C-13 NMR, and mass spectra). Some of the synthesized derivatives were screened for their antitumor activity against four human tumor cell lines using MTT assay. In comparison with doxorubicin as standard drug, compounds 1, 20, and 25 showed the most potent cytotoxic effect. In addition, investigation of antioxidant activity revealed that hydrazinylphthalazine 20 has the highest activity.

We’ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 36809-26-4. The above is the message from the blog manager. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and their interactions with reaction intermediates and transition states. 62-23-7, Name is 4-Nitrobenzoic acid, molecular formula is C7H5NO4, belongs to phthalazine compound. In a document, author is Eldehna, Wagdy M., introduce the new discover, Recommanded Product: 4-Nitrobenzoic acid.

A series of anilinophthalazine derivatives 4a-j was initially synthesized and tested for its VEGFR-2 inhibitory activity where it showed promising activity (IC50 = 0.636-5.76 mu M). Molecular docking studies guidance was used to improve the binding affinity for series 4a-j towards VEGFR-2 active site. This improvement was achieved by increasing the hydrophobic interaction with the hydrophobic back pocket of the VEGFR-2 active site lined with the hydrophobic side chains of Ile888, Leu889, Ile892, Val898, Val899, Leu1019 and Ile1044. Increasing the hydrophobic interaction was accomplished by extending the anilinophthalazine scaffold with a substituted phenyl moiety through an uriedo linker which should give this extension the flexibility required to accommodate itself deeply into the hydrophobic back pocket. As planned, the designed uriedo-anilinophthalazines 7a-i showed superior binding affinity than their anilinophthalazine parents (IC50 = 0.083-0.473 mu M). In particular, compounds 7g-i showed IC50 of 0.086, 0.083 and 0.086 mu M, respectively, which are better than that of the reference drug sorafenib (IC50 = 0.09 mu M). (C) 2016 Elsevier Masson SAS. All rights reserved.

Interested yet? Keep reading other articles of 62-23-7, you can contact me at any time and look forward to more communication. Recommanded Product: 4-Nitrobenzoic acid.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem