Chemical engineers ensure the efficiency and safety of chemical processes, adapt the chemical make-up of products to meet environmental or economic needs, and apply new technologies to improve existing processes. 56-95-1, Name is Chlorhexidine Diacetate, SMILES is N=C(NCCCCCCNC(NC(NC1=CC=C(Cl)C=C1)=N)=N)NC(NC2=CC=C(Cl)C=C2)=N.CC(O)=O.CC(O)=O, belongs to phthalazine compound. In a document, author is Yu, Li-Jun, introduce the new discover, Name: Chlorhexidine Diacetate.
In a previous research, we found a compound named 6-(3-(trifluoromethyl)-benzyloxy)-[1,2,4]triazolo[3,4-a]phthalazine (BM-1) much more effective in the maximal electroshock (MES) model for mouse and much safer in the neurotoxicity (NT) screening, which indicated that it may be used as antiepileptic drug. But, those evaluations were too rough. So in this study, we did more work to assess the anticonvulsant activity and the toxicity about BM-1. The peak times of protection of BM-1 after intraperitoneal injection (ip) and oral administration (po) were determined using the MES test, and the anticonvulsant activity of it was compared with the reference drug, carbamazepine, at these peak times. The rotarod test was applied to measure its neurotoxicity. When compared with the reference drug in the maximal electroshock (MES) test at the time to peak effect, it showed that BM-1 was much more effective and safer than reference drug Carbamazepine with ED50 of 11.2 mg/kg, TD50 of 72.2 mg/kg and PI of 6.5 after administration of ip, while when administered orally, that values of ED50, TD50 and PI of BM-1-1, BM-1-2 and BM-1-3 were much better than Carbamazepine and BM-1 after po. The compound BM-1 has more effective anticonvulsant activity and lower neurotoxicity administered by both ip and po. So BM-1 could may be used instead of the prescribed antiepileptic drugs (AEDs) in the future.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem