Application of 81-16-3, Reactions catalyzed within inorganic and organic materials and at electrochemical interfaces commonly occur at high coverage and in condensed media, causing turnover rates to depend strongly on interfacial structure and composition. 81-16-3, Name is 2-Aminonaphthalene-1-sulfonic acid, SMILES is O=S(C1=C2C=CC=CC2=CC=C1N)(O)=O, belongs to phthalazine compound. In a article, author is Karishma, Pidiyara, introduce new discover of the category.
A direct carbocyclization of 2-aryl-2,3-dihydrophthalazine-1,4-diones is achieved using isocyanates as carbonyl source via Ru(II)-catalyzed sequential ortho-amidation followed by intramolecular nucleophilic substitution, delivering substituted indazolo[1,2-b]phthalazine-triones in good-to-excellent yields. For ortho-substituted 2-aryl-2,3-dihydrophthalazine-1,4-diones, the corresponding amidated products were also isolated in excellent yields by modifying the reaction parameters. Application of isocyanates as carbonyl source, high functional group tolerance on the two coupling partners and diverse chemical transformation of the synthesized fused and functionalized phthalazinones are the key highlights of the work.
Application of 81-16-3, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 81-16-3.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem