Month: August 2021

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 90-64-2, Name is 2-Hydroxy-2-phenylacetic acid, molecular formula is C8H8O3, Application In Synthesis of 2-Hydroxy-2-phenylacetic acid, belongs to phthalazine compound, is a common compound. In a patnet, author is El-Gazzar, Marwa G., once mentioned the new application about 90-64-2.

Aims and Objective: A series of novel phthalazine derivatives was synthesized with versatile, readily accessible electrophilic and nucleophilic reagents. The newly synthesized compounds were confirmed by the results of spectroscopic measurements. Hence, their potential clinical application investigated in particular for cancer treatment. Materials and Methods: The newly synthesized compounds were characterized by spectroscopic measurements and were tested for their in vitro anticancer activity by MTT assay against human liver cancer cell line. Docking study of all the synthesized compounds was performed within the active site of the enzyme VEGFR-2 (Vascular Endothelial Growth Factor Receptor-2). Results: The quinazoline derivative 12 emerged as the most potent compound in this study with an IC50 value of 5.4 mu M. Docking study showed that the synthesized compounds were fit in the VEGFR-2 active site almost at the same position of sorafenib and vatalanib with comparable docking scores (-15.20 to -8.92 was kcal/mol). Conclusion: we have synthesized a novel series of phthalazine derivatives and evaluated their potential anticancer activity against HEPG2 cell line. The quinazoline derivative 12 emerged as the most potent compound in this study with an IC50 value of 5.4 mu M. The SAR and docking studies pointed out that rigidification of the structure resulted in better activity and better binding within the active site of VEGFR-2 as in compounds 3, 5, 6 and 12. These results introduced new phthalazine derivatives having promising activity which could lead to the development of more potent anticancer agents.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Chemistry involves the study of all things chemical – chemical processes, chemical compositions and chemical manipulation – in order to better understand the way in which materials are structured, how they change and how they react in certain situations. , Safety of Boc-D-Phenylglycinol, 102089-74-7, Name is Boc-D-Phenylglycinol, molecular formula is C13H19NO3, belongs to phthalazine compound. In a document, author is Elmi-Mehr, M., introduce the new discover.

Some new derivatives of 3-amino-1-aryl-N-butyl-5,10-dioxo-5,10-dihydro-1H-pyrazolo[1,2-b]- phthalazine-2-carboxamide are synthesized via in situ Knoevenagel condensation of aromatic aldehydes with N-butyl-2-cyanoacetamide, which leads to 3-aryl-N-butyl-2-cyanoacrylamides. This is followed by the reaction with phthalhydrazide upon refluxing in ethanol under catalyst-free conditions. The products are characterized on the basis of IR, H-1 and C-13 NMR spectral data.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: Ethyl cinnamate, In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 103-36-6, Name is Ethyl cinnamate, SMILES is O=C(OCC)/C=C/C1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Shekouhy, Mohsen, introduce new discover of the category.

A catalyst-free one-pot four component methodology for the synthesis of 2H-indazolo[2,1-b]phthalazine-triones under ultrasonic irradiation at room temperature using 1-butyl-3-methylimidazolium bromide, [Bmim]Br, as a neutral reaction medium is described. A broad range of structurally diverse aldehydes (aromatic aldehydes bearing electron withdrawing and/or electron releasing groups as well as heteroaromatic aldehydes) were applied successfully, and corresponding products were obtained in good to excellent yields without any byproduct. (C) 2011 Elsevier B.V. All rights reserved.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 103-36-6 is helpful to your research. Name: Ethyl cinnamate.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. 140-75-0, Name is (4-Fluorophenyl)methanamine, SMILES is C1=C(C=CC(=C1)F)CN, in an article , author is Shaterian, Hamid Reza, once mentioned of 140-75-0, Quality Control of (4-Fluorophenyl)methanamine.

A new four-component synthesis of 1H-pyrazolo[1,2-b]phthalazine-5,10-dione derivatives using three weak basic ionic liquids such as 1,8-diazabicyclo[5.4.0]-undec-7-en-8-ium acetate, pyrrolidinium formate, and pyrrolidinium acetate as efficient catalysts for condensation reaction of hydrazine monohydrate, phthalic anhydride, malononitrile or ethyl cyanoacetate, and aromatic aldehydes under ambient and solvent-free conditions in excellent yields is described. (C) 2012 Elsevier B.V. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

You could be based in a university, combining chemical research with teaching; in a pharmaceutical company, working on developing and trialing new drugs; helping to ensure national healthcare provision keeps pace with new discoveries. 618-88-2, Name is 5-Nitroisophthalic acid, SMILES is O=C(O)C1=CC([N+]([O-])=O)=CC(C(O)=O)=C1, belongs to phthalazine compound. In a document, author is Lavrenova, L. G., introduce the new discover, Safety of 5-Nitroisophthalic acid.

Coordination compounds of iron(II) thiocyanate with tris(3,5-dimethylpyrazol-1-yl)methane (HC(3,5-Me(2)Pz)(3)), [Fe(HC(3,5-Me(2)Pz)(3))(2)](NCS)(2)] (I) and [Fe(HC(3,5-Me(2)Pz)(3))(D hz)(NCS)(2)] center dot H2O (II), where D hz is phthalazine, are synthesized. The complexes are studied by X-ray diffraction analysis, diffuse reflectance and IR spectroscopy, and static magnetic susceptibility measurements. The single crystals are obtained, and the molecular and crystal structures of complex II and compounds [Fe(HC(3,5-Me(2)Pz)(3))(3,5-Me(2)Pz)(NCS)(2)] center dot D2H5OH (III), where 3,5-Me(2)Pz is 3,5-dimethylpyrazole, and [Fe(HC(3,5-Me(2)Pz)(3))(2)][Fe(HC(3,5-Me(2)Pz)(3))(NCS)(3)](2) (IV) are determined (CIF files CCDC 1415452 (II), 1415453 (III), and 1415454 (IV)). The study of the temperature dependence mu(eff)(D cent) in a range of 2-300 K shows exchange interactions of the antiferromagnetic character between the iron(II) ions in complexes I and II.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 618-88-2 help many people in the next few years. Formula: https://www.ambeed.com/products/618-88-2.html.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Some examples of the diverse research done by chemistry experts include discovery of new medicines and vaccines, improving understanding of environmental issues, and development of new chemical products and materials. 482-05-3, Name is [1,1′-Biphenyl]-2,2′-dicarboxylic acid, molecular formula is C14H10O4, Recommanded Product: [1,1′-Biphenyl]-2,2′-dicarboxylic acid, belongs to phthalazine compound, is a common compound. In a patnet, author is Zhu, Guanxing, once mentioned the new application about 482-05-3.

Intramolecular electrophilic cyclization of a bisanthranilate afforded an angular cis-quinacridone compound, which condensed with hydrazine to give a phthalazine derivative. A [2+2+2] cyclization reaction occurred at the C-N double bond position of phthalazine when reacted with dimethyl acetylenedicarboxylate. The structures of these novel compounds were confirmed by crystallographic analysis. The phthalazine derivative decomposes back to quinacridone at ambient condition in the dark and as a solid with a half lifetime of about 22 months.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

With the volume and accessibility of scientific research increasing across the world, it has never been more important to continue building the reputation for quality and ethical publishing we’ve spent the past two centuries establishing. 1149-26-4, Name is Z-L-Val-OH, SMILES is CC(C)[C@@H](C(O)=O)NC(OCC1=CC=CC=C1)=O, in an article , author is Almeida, Marilia O., once mentioned of 1149-26-4, Formula: https://www.ambeed.com/products/1149-26-4.html.

The fermentation of the endophyte Fusarium oxysporum SS46 and Fusarium oxysporum ATCC MYA 4623 with epigenetic modulator hydralazine in Czapek medium led to the isolation of 3-methyl-1,2,4-triazolo [3,4-alpha] phthalazine (1). The mechanism of biotransformation involves reaction with acetyl-CoA and further cyclization, and was unveiled using C-13-precursor. Additionally, AFLP technique for genomic DNA and differential gene expression (cDNA) analyses were applied for comparative profiling of the fungus under and without treatment with hydralazine. There was no change in the DNA profile of hydralazine-treated and non-treated cultures; however, cDNA-AFLP analyses showed a differential gene expression in the cultures after treatment of the fungi with hydralazine.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 122-99-6, Chemistry graduates have much scope to use their knowledge in a range of research sectors, including roles within chemical engineering, chemical and related industries, healthcare and more. 122-99-6, Name is 2-Phenoxyethanol, SMILES is OCCOC1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Revathy, Krishnan, introduce new discover of the category.

We have developed a potential method for the synthesis of biologically activel 2,2′-dimethyl-13-phenyl-2,3-dihydro-1H-indazolo[2,1-b]phthalazine-1,6,11(13H)-trione and its derivatives via an one-pot, four-component synthesis of phthalic anhydride, hydrazine, aromatic aldehydes and dimedone in the presence of ceric ammonium nitrate (CAN) at room temperature. The reaction was completed within 30 min yielding 70-90% of the corresponding product. The reaction was extended to different aldehydes and anhydrides leading to good yields in all the cases.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 122-99-6 is helpful to your research. Recommanded Product: 122-99-6.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 36809-26-4, Academic researchers, R&D teams, teachers, students, policy makers and the media all rely on us to share knowledge that is reliable, accurate and cutting-edge. 36809-26-4, Name is (4-Bromophenyl)diphenylamine, SMILES is BrC1=CC=C(N(C2=CC=CC=C2)C3=CC=CC=C3)C=C1, belongs to phthalazine compound. In a article, author is Romero, Angel H., introduce new discover of the category.

With the aim to identify a potential drug candidate to treat cutaneous leishmaniasis, a series of 1-phthalazinyl hydrazones were synthesized and tested against Leishmania braziliensis parasite, one of the main responsible of this disease in the world. A structure-activity relationship permitted to identify two phthalazines containing nitroheterocyclic moiety 31 and 3m as promising new lead compounds. These compounds showed a significant antileishmanial activity against promastigote form of L. braziliensis, with EC50 values in sub-micromolar and nanomolar ranges. The phthalazine 31 also displayed a selective and excellent activity against the clinically relevant intracellular amastigotes form, with a EC50 value in sub-micromolar range (0.59 mu M), without affecting the viability of the host cells. Oxidative stress was identified as the possible mode of action of the most active phthalazine. Considering their significant antileishmanial activity and ease synthesis, the phthalazine containing nitroheterocyclic represents a promising agent against Leishmania braziliensis for the rational design of new leads. (C) 2017 Elsevier Masson SAS. All rights reserved.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines, We’ll be discussing some of the latest developments in chemical about CAS: 696-63-9, Name is 4-Methoxythiophenol, SMILES is SC1=CC=C(OC)C=C1, belongs to phthalazine compound. In a article, author is Abou-Seri, Sahar M., introduce new discover of the category.

In our endeavor towards the development of effective VEGFR-2 inhibitors, three novel series of phthalazine derivatives based on 1-piperazinyl-4-arylphthalazine scaffold were synthesized. All the newly prepared phthalazines 16a-k, 18a-e and 21a-g were evaluated in vitro for their inhibitory activity against VEGFR-2. In particular, compounds 16k and 21d potently inhibited VEGFR-2 at sub-micromolar IC50 values 0.35 +/- 0.03 and 0.40 +/- 0.04 mu M, respectively. Moreover, seventeen selected compounds 16c-e, 16g, 16h, 16j, 16k, 18c-e and 21a-g were evaluated for their in vitro anticancer activity according to US-NCI protocol, where compounds 16k and 21d proved to be the most potent anticancer agents. While, compound 16k exhibited potent broad spectrum anticancer activity with full panel GI(50) (MG-MID) value of 3.62 mu M, compound 21d showed high selectivity toward leukemia and prostate cancer subpanels [subpanel GI(50) (MG-MID) 3.51 and 5.15 mu M, respectively]. Molecular docking of compounds16k and 21d into VEGFR-2 active site was performed to explore their potential binding mode. (C) 2015 Elsevier Masson SAS. All rights reserved.

Interested yet? Read on for other articles about 696-63-9, you can contact me at any time and look forward to more communication. Category: phthalazines.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem