Related Products of 24650-42-8, Career opportunities within science and technology are seeing unprecedented growth across the world, and those who study chemistry or another natural science at university now have increasingly better career prospects. 24650-42-8, Name is 2,2-Dimethoxy-2-phenylacetophenone, SMILES is COC(OC)(C(=O)C1=CC=CC=C1)C1=CC=CC=C1, belongs to phthalazine compound. In a article, author is Sanchez-Moreno, Manuel, introduce new discover of the category.
A series of new phthalazine derivatives 1-4 containing imidazole rings were prepared. The monoalkylamino substituted. derivatives 2 and 4 were more active in vitro against T. cruzi and less toxic against Vero cells than both their disubstituted analogues and the reference drug benznidazole. Compounds 2 and 4 highly inhibited the antioxidant parasite enzyme Fe-SOD, and molecular modeling suggested that they interact with the H-bonding system of the iron atom moiety. In vivo tests on the acute phase of Chagas disease gave parasitemia inhibition values twice those of benznidazole, and a remarkable decrease in the reactivation of parasitemia was found in the chronic phase for immunodeficient mice. Glucose metabolism studies showed that compounds 1-4 did not affect the succinate pathway but originated important changes in the excretion of pyruvate metabolites. The morphological alterations found in epimastigotes treated with 1-4 confirmed extensive cytoplasm damage and a high mortality rate of parasites.
Related Products of 24650-42-8, Because enzymes can increase reaction rates by enormous factors and tend to be very specific, typically producing only a single product in quantitative yield, they are the focus of active research.you can also check out more blogs about 24650-42-8.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem