Month: October 2021

I found the field of Chemistry very interesting. Saw the article Asymmetric Diels-Alder reaction of 3-(acyloxy)acryloyl oxazolidinones: optically active synthesis of a high-affinity ligand for potent HIV-1 protease inhibitors published in 2019.0. SDS of cas: 62-23-7, Reprint Addresses Ghosh, AK (corresponding author), Purdue Univ, Dept Chem, 560 Oval Dr, W Lafayette, IN 47907 USA.; Ghosh, AK (corresponding author), Purdue Univ, Dept Med Chem & Mol Pharmacol, 560 Oval Dr, W Lafayette, IN 47907 USA.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

We describe here our investigation of the asymmetric Diels-Alder reaction of chiral 3-(acyloxy)acryloyl oxazolidinones as dienophiles in various Lewis-acid promoted reactions with cyclopentadiene. The resulting highly functionalized cycloadducts are useful intermediates for the synthesis, particularly for the optically active synthesis of 6-5-5 tricyclic hexahydro-4H-3,5-methanofuro[2,3-b]pyranol (3) with five contiguous chiral centers. This stereochemically defined crown-like heterocyclic derivative is an important high affinity ligand for a variety of highly potent HIV-1 protease inhibitors. Among the various dienophiles and Lewis acid-mediated reactions surveyed, 3-(4-methoxybenzoyl)acryloyl oxazolidinone as the dienophile and diethylaluminum chloride as the Lewis-acid provided the desired endo product with excellent diastereoselectivity. The cycloaddition was carried out in multi-gram scale and the cycloadduct was efficiently converted to alcohol 3 with high enantiomeric purity. The optically active ligand was then transformed into potent HIV-1 protease inhibitor 2.

SDS of cas: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Ghosh, AK; Grillo, A; Kovela, S; Brindisi, M or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

HPLC of Formula: C7H5NO4. Recently I am researching about CROSS-COUPLING REACTION; NUCLEOPHILIC AROMATIC-SUBSTITUTION; PALLADIUM-CATALYZED SILYLATION; C-F ACTIVATION; ARYL FLUORIDES; GRIGNARD-REAGENTS; ALPHA-ARYLATION; POLYFLUOROARENES; BORYLATION; CLEAVAGE, Saw an article supported by the ICIQ, MINECO [CTQ2015-65496-R]; European UnionEuropean Commission [702563]; MINECO. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Liu, XW; Zarate, C; Martin, R. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The ability to selectively forge C-heteroatom bonds by C-F scission is typically accomplished by metal catalysts, specialized ligands and/or harsh reaction conditions. Described herein is a base-mediated defluorosilylation of unactivated C(sp(2))-F and C(sp(3))-F bonds that obviates the need for metal catalysts. This protocol is characterized by its simplicity, mild reaction conditions, and wide scope, even within the context of late-stage functionalization, constituting a complementary approach to existing C-Si bond-forming protocols.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Liu, XW; Zarate, C; Martin, R or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article A graphdiyne-based carbon material for electroless deposition and stabilization of sub-nanometric Pd catalysts with extremely high catalytic activity WOS:000471010900020 published article about METAL NANOPARTICLE CATALYSTS; CHEMISTRY; NANOCLUSTERS; SUBSTRATE; CLUSTERS; RAMAN in [Yang, Liang-Liang; Wang, Hong-Juan; Wang, Juan; Li, Yu; Zhang, Wen; Lu, Tong-Bu] Tianjin Univ Technol, Sch Mat Sci & Engn, Inst New Energy Mat & Low Carbon Technol, Tianjin 300384, Peoples R China; [Lu, Tong-Bu] Sun Yat Sen Univ, Sch Chem, MOE Key Lab Bioinorgan & Synthet Chem, Guangzhou 510275, Guangdong, Peoples R China in 2019.0, Cited 53.0. Computed Properties of C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The development of sub-nanometric metal particles (<1 nm) as advanced heterogeneous catalysts has received considerable interest due to their outstanding catalytic performance, while the synthesis and stabilization of sub-nanometric catalysts (SNCs) without using additional surface capping agents remains a challenge. Herein, we report the synthesis of novel three-dimensional pyrenyl graphdiyne (Pyr-GDY) ultrafine nanofibers (3-10 nm), which can serve as an ideal substrate for electroless deposition and stabilization of Pd SNCs through the terminal uncoupled acetenyl groups in Pyr-GDY, with an average Pd particle size of only 0.83 nm. The as-synthesized Pd/Pyr-GDY composite shows extremely high catalytic activities for the reduction of nitroarenes to arylamines and Suzuki coupling reactions, 300 and 25 times higher than those of commercial Pd/C, respectively. The outstanding catalytic performance can be ascribed to the sub-nanometric Pd particles with a clean surface, and the unique three-dimensional network structure of Pyr-GDY, being favorable for rapid mass transfer. Our result provides an ideal carbon material for electroless deposition and stabilization of other SNCs with a clean surface, which will display outstanding catalytic activity for various catalytic reactions. Computed Properties of C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Yang, LL; Wang, HJ; Wang, J; Li, Y; Zhang, W; Lu, TB or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of 4-Nitrobenzoic acid. Haito, A; Chatani, N in [Haito, Akira; Chatani, Naoto] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan published Rh(i)-Catalyzed [3+2] annulation reactions of cyclopropenones with amides in 2019.0, Cited 28.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Rh(I)-Catalyzed [3+ 2] annulation reactions of cyclopropenones with amides are reported. The reaction provides a direct approach for producing highly substituted alpha, beta-unsaturated gamma-lactam derivatives. The presence of an N(sp(2)) atom in the N-alkyl group of the amide, such as the 2-pyridinylmethyl or 8-aminoquinonyl group, is essential for the success of the reaction.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Haito, A; Chatani, N or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article A Unified Synthetic Approach to Optically Pure Curvularin-Type Metabolites WOS:000471212000062 published article about STEREOSELECTIVE TOTAL-SYNTHESIS; SYNTHASE EXPRESSION; (S)-CURVULARIN; CONSTRUCTION; AETHERAMIDES; MACROLIDES; INHIBITORS in [Allu, Srinivasa Rao; Banne, Sreenivas; Jiang, Jia; Qi, Na; Guo, Jian; He, Yun] Chongqing Univ, Sch Pharmaceut Sci, Chongqing Key Lab Nat Prod Synth & Drug Res, Chongqing 401331, Peoples R China; [Qi, Na] Chongqing Univ, Coll Bioengn, Biomed & Hlth Engn Lab, Chongqing 401331, Peoples R China in 2019.0, Cited 40.0. Safety of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A unified and concise approach to the synthesis of nine curvularin-type metabolites and two analogues has been developed with few steps and high yields. Among them, sumalactones A-D were synthesized for the first time. The key steps in this approach included esterification, Friedel-Crafts acylation, and ring-closing metathesis (or cross metathesis).

Safety of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Allu, SR; Banne, S; Jiang, J; Qi, N; Guo, J; He, Y or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Heterogeneous Suzuki-Miyaura coupling of heteroaryl ester via chemoselective C(acyl)-O bond activation WOS:000471912700036 published article about CATALYZED C-O; ARYL ESTERS; NICKEL; AZOLES; SILYLATION; AMINATION; CLEAVAGE; KETONES; AMIDE in [Ma, Hongpeng; Bai, Chaolumen; Bao, Yong-Sheng] Inner Mongolia Normal Univ, Coll Chem & Environm Sci, Inner Mongolia Key Lab Green Catalysis, Hohhot 010022, Peoples R China in 2019, Cited 47. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

A site-selective supported palladium nanoparticle catalyzed Suzuki-Miyaura cross-coupling reaction with heteroaryl esters and arylboronic acids as coupling partners was developed. This methodology provides a heterogeneous catalytic route for aryl ketone formation via C(acyl)-O bond activation of esters by successful suppression of the undesired decarbonylation phenomenon. The catalyst can be reused and shows high activity after eight cycles. The XPS analysis of the catalyst before and after the reaction suggested that the reaction might be performed via a Pd-0/Pd-II catalytic cycle that began with Pd-0.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, HP; Bai, CLM; Bao, YS or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

He, ZL; Liu, J; Wang, QJ; Zhao, W; Wen, ZP; Chen, J; Manoj, D; Xie, CY; Xi, JB; Yu, JX; Tang, CY; Bai, ZW; Wang, S in [He, Zhaolin; Liu, Jin; Zhao, Wang; Wen, Zhipan; Chen, Jun; Xi, Jiangbo; Yu, Junxia; Bai, Zhengwu] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Hubei, Peoples R China; [Wang, Qijun; Manoj, Devaraj; Xie, Chuyi; Wang, Shuai] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Mat Chem Energy Convers & Storage, Minist Educ, Wuhan 430074, Hubei, Peoples R China; [Tang, Chunyan] Guangxi Univ, Sch Comp Elect & Informat, Nanning 530004, Guangxi, Peoples R China published Metal-free carbocatalyst for catalytic hydrogenation of N-containing unsaturated compounds in 2019.0, Cited 53.0. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Eco-friendly carbocatalyst is extremely desirable in organic catalysis and wastewater treatment. Herein, we reported a one-pot synchronous hydrothermal process to synthesize a highly efficient N doped holey graphene (NHG) carbocatalyst, in which graphene oxide nanosheets are self-assembled, reduced, chemically etched, and simultaneously doped with nitrogen to form a graphene hydrogel in the presence of H2O2 and NH4OH. Benefiting from the good hydrophilicity, unique hierarchical porous structure, large specific surface area (322.1 m(2)g(-1)), and high N content (9.77 at. %), the resultant NHG carbocatalyst exhibits an excellent catalytic performance for the hydrogenation of N-containing unsaturated compounds. In 4-nitrophenol reduction reaction, the NHG carbocatalyst delivers a turnover frequency of 3.32 x 10(-2) min(-1). This catalytic activity is superior to that of the commercial Pd/C (5.0 wt%), other previously reported carbocatalysts, and many noble-metal-based catalysts. Furthermore, the molecular structure analysis combined with density functional theory calculations elucidate metal-free catalytic mechanism of hydrogenation reaction for unsaturated chromophore groups in N-containing organic dyes. (C) 2019 Elsevier Inc. All rights reserved.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact He, ZL; Liu, J; Wang, QJ; Zhao, W; Wen, ZP; Chen, J; Manoj, D; Xie, CY; Xi, JB; Yu, JX; Tang, CY; Bai, ZW; Wang, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Novel Pyrazolo[3,4-d]pyrimidine-Containing Amide Derivatives: Synthesis, Molecular Docking, In Vitro and In Vivo Antidiabetic Activity WOS:000490895800027 published article about BIOLOGICAL EVALUATION; DIABETES-MELLITUS; INHIBITORS; ANTIBACTERIAL; PYRIMIDINE; DIET in [Reddy, Bijivemula N.; Pathak, Madhvesh] Vellore Inst Technol, Sch Adv Sci, Vellore 632014, Tamil Nadu, India; [Ruddarraju, Radhakrishnam Raju] Factory Plot 79-B&C, Patancheru 502307, Andhra Pradesh, India; [Ruddarraju, Radhakrishnam Raju] Jawaharlal Nehru Technol Univ, Hyderabad 500085, Telangana, India; [Kiran, Gangarapu] Anurag Grp Inst, Dept Pharmaceut Anal & Chem, Sch Pharm, Ghatkesar M, Telangana, India; [Reddy, Anreddy Rama Narsimha] Jyothishmathi Inst Pharmaceut Sci, Dept Pharmacol, Karimnagar 505481, Telangana, India in 2019, Cited 45. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A new series of Pyrazolo[3,4-d]pyrimidine containing amide derivatives (8 a-l) were designed, synthesized, and evaluated for their in vitro alpha-amylase inhibitory activity. The IC50 values of the target compounds ranged from 1.60 +/- 0.48 to 2.04 +/- 1.20 mu M as compared to the standard acarbose 1.73 +/- 0.05 mu M. All the Pyrazolo[3,4-d]pyrimidine amide derivatives displayed good inhibitory activities, while seven analogs (8 d, 8 f, 8 g, 8 h, 8 i, 8 j and 8 k) exhibited more or less equipotent activity with IC50 values 1.77 +/- 2.84, 1.65 +/- 0.45, 1.66 +/- 2.24, 1.73 +/- 0.37, 1.60 +/- 0.48, 1.75 +/- 0.36 and 1.64 +/- 0.03 mu M respectively. Further, the most potent alpha-amylase inhibitors 8 d and 8 k were also screened for their in vivo antidiabetic activity against alloxan induced diabetic rat model at the dose of 25 and 50 mg/kg. Oral administration of these tested compounds significantly reduced the fasting blood glucose levels in dose dependent manner. The hypoglycemic effects of these compounds were more evident at 3 h and 5 h after administration of tested compounds which was similar to the effect displayed by the positive control. In addition, the binding energies calculated from the docking studies with the alpha-amylase enzyme (PDB ID: 1HNY) and biological activities indicate that the compounds containing nitro moiety on the phenyl group contributed significantly towards the antidiabetic activity.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Reddy, BN; Ruddarraju, RR; Kiran, G; Pathak, M; Reddy, ARN or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 EUR J MED CHEM published article about MULTIDRUG-RESISTANT; ANTIMYCOBACTERIAL ACTIVITY; PHARMACOLOGICAL EVALUATION; ANTITUBERCULOSIS ACTIVITY; ANTICANCER ACTIVITY; DERIVATIVES; TUBERCULOSIS; THIADIAZOLES; CYTOTOXICITY; BEDAQUILINE in [Patel, Harun; Jadhav, Harsha; Ansari, Iqrar; Pawara, Rahul; Surana, Sanjay] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Shirpur, India in 2019, Cited 33. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

In the present study, a series of substituted 1,3,4-thiadiazole derivatives 4(a-o), 5(a-m) and 6(a-j) were synthesized and characterized by IR, H-1 NMR, C-13 NMR and mass spectroscopic technique. The synthesized compounds were evaluated for their in vitro anti-mycobacterial activity against the Mycobacterium tuberculosis H37Rv and resistance MDR-TB strain. Among the compounds tested N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)furan-2-carboxamide (4h) showed significant inhibitory activity with MIC of 9.87 mu M (H37Rv strain) and 9.87 mu M (MDR-TB strain) compared to isoniazide (MIC of 3.64 mu M (H37Rv) and >200 mu M (MDR-TB strain)] and rifampin [MIC of 0.152 mu M (H37Rv) and 128 mu M (MDR-TB strain)]. In addition, these compounds have also been assessed for their cyto-toxicity to a mammalian Vero cell line using the MTT assay. The result shows that these compounds exhibit anti-tubercular activity at non-cytototoxic concentrations. (C) 2019 Elsevier Masson SAS. All rights reserved.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Patel, H; Jadhav, H; Ansari, I; Pawara, R; Surana, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Rhodium-catalysed synthesis of fused pyrimidine derivatives employing N-sulfonyl-1,2,3-triazoles as a 1-aza-[4C] synthon WOS:000474321900010 published article about DIELS-ALDER REACTIONS; ALPHA,BETA-UNSATURATED IMINES; TANDEM REACTION; 1,2,3-TRIAZOLES; TRANSANNULATION; CYCLOADDITION; 2H-AZIRINES; ANNULATION; ALKYNES; 1-SULFONYL-1,2,3-TRIAZOLES in [Xu, Ze-Feng; An, Yuehui; Chen, Yidian; Duan, Shengguo] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Peoples R China; [Xu, Ze-Feng] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019, Cited 59. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

A new synthetic application of N-sulfonyl-1,2,3-triazoles acting as a 1-aza-[4C] synthon via the 1,2-shift reaction of an alpha-imine rhodium carbene was developed for the synthesis of fused pyrimidine derivatives. The high reactivity of the strained three-membered 2H-azirine ring facilitated the unusual cyclization of electron-deficient dienes with electron-deficient dienophiles. The compatibility was good with common functionalities tolerated. Excellent chemoselectivity was observed, and no reactions occurred between the rhodium carbene and 2H-azirine. The products could be converted into seven-membered multi-functionalized 1H-1,4-diazepine derivatives, illustrating the potential application of the protocol in medium-sized N-heterocycle synthesis. (C) 2019 Elsevier Ltd. All rights reserved.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Xu, ZF; An, YH; Chen, YD; Duan, SG or concate me.. HPLC of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem