Name: 4-Nitrobenzoic acid. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles published in 2019.0, Reprint Addresses Couri, MRC (corresponding author), Univ Fed Juiz de Fora, Dept Quim, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.
A series of1,2,4- and 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Halogenated 1,2,4-oxadiazoles were obtained from benzonitrile and coupled either lipophilic amines or with aminoalcohols. Lipophilic 1,3,4-oxadiazole derivatives were obtained through the Mannich reactions between 5-(aryl)-1,3,4-oxadiazole-2-thiol and alkylated or acylated amines. The in vitro cytotoxic effects were evaluated against 4T1- mammary carcinoma and CT26 – colon cancer cells. The best results were obtained for the 1,3,4-oxadiazole coupled to alkylated piperazine with 10-14 carbon chain moiety, with IC50 values ranging from 1.6 to 3.55 mu M for the 4T1 cell line, and from 1.6 to 3.9 mu M for the CT26.WT cell line, and selectivity index up to 19. The most potent compounds were investigated with AnnexinV and PI staining as indicative of apoptosis induction. (C) 2019 Published by Elsevier Masson SAS.
About 4-Nitrobenzoic acid, If you have any questions, you can contact Caneschi, W; Enes, KB; de Mendonca, CC; Fernandes, FD; Miguel, FB; Martins, JD; Le Hyaric, M; Pinho, RR; Duarte, LM; de Oliveira, MAL; Dos Santos, HF; Lopes, MTP; Dittz, D; Silva, H; Couri, MRC or concate me.. Name: 4-Nitrobenzoic acid
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem