Recently I am researching about ALZHEIMERS-DISEASE; OXIDATIVE STRESS; CELECOXIB; DESIGN; APOPTOSIS; ACID; MICE, Saw an article supported by the Science and Technology Planning Program of Guangzhou [201704020146]; Science and Technology Planning Program of Guangdong Province [509164523031]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Liao, LP; Jiang, CB; Chen, JW; Shi, JG; Li, XH; Wang, Y; Wen, J; Zhou, SJ; Liang, J; Lao, YQ; Zhang, JX. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Category: phthalazines
A series of 1,2,4-triazole derivatives 1-14 was synthesized to investigate their neuroprotective effects and mechanisms of action. Compounds 5-11 noticeably protected PC12 cells from the cytotoxicity of H2O2 or sodium nitroprusside (SNP). Compound 11 was the most effective derivative. Compound 11 chelated Fe (II) iron, scavenged reactive oxygen species (ROS), and restored the mitochondrial membrane potential (MMP). Moreover, it enhanced the activity of the antioxidant defense system by increasing the serum level of superoxide dismutase (SOD) and promoting the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). Compound 11 caused certain improvements in behavior, the cerebral infarction area, and serum levels of biochemical indicators (TNF-alpha, IL-10, SOD and MDA) in a rat MCAO model. The lethal dose (LD50) of compound 11 in mice receiving intraperitoneal injections was greater than 400 mg/kg. Meanwhile, pharmacokinetic experiments revealed high bioavailability of this compound after both oral and intravenous administration (F = 60.76%, CL = 0.014 mg/kg/h) and a longer half-life (4.26 and 5.11 h after oral and intravenous administration, respectively). Based on these findings, compound 11 may be a promising neuroprotectant for the treatment of ischemic stroke. (C) 2020 Elsevier Masson SAS. All rights reserved.
Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Liao, LP; Jiang, CB; Chen, JW; Shi, JG; Li, XH; Wang, Y; Wen, J; Zhou, SJ; Liang, J; Lao, YQ; Zhang, JX or concate me.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem