An article Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists WOS:000460692100009 published article about ABA-INDEPENDENT INHIBITION; 2C PROTEIN PHOSPHATASES; MOLECULAR-BASIS; MECHANISM; ANALOGS; INSIGHTS; KINASES; COMPLEX; BINDING; CELL in [Mikame, Yu; Hirai, Go; Sodeoka, Mikiko] RIKEN Cluster Pioneering Res, Synthet Organ Chem Lab, 2-1 Hirosawa, Wako, Saitama 3510198, Japan; [Mikame, Yu; Nagasawa, Kazuo] Tokyo Univ Agr & Technol, Dept Life Sci & Biotechnol, 2-24-16 Naka Cho, Koganei, Tokyo 1848588, Japan; [Yoshida, Kazuko; Hirai, Go; Osada, Hiroyuki; Sodeoka, Mikiko] RIKEN Ctr Sustainable Resource Sci, 2-1 Hirosowa, Wako, Saitama 3510198, Japan; [Hashizume, Daisuke] RIKEN Ctr Emergent Matter Sci, 2-1 Hirosowa, Wako, Saitama 3510198, Japan; [Hirai, Go; Sodeoka, Mikiko] Kyushu Univ, Grad Sch Pharmaceut Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka, Fukuoka 8128582, Japan in 2019.0, Cited 47.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Category: phthalazines
The PYR/PYL/RCAR protein families have recently emerged as receptors of the phytohormone abscisic acid (ABA, 1), which regulates plant responses to environmental stress. These families have multiple members with different physiological actions, and so selective agonists or antagonists are needed both as tools to elucidate functional differences and as lead compounds for agrochemicals. We previously identified RK460 (rac-3 a) as a PYR1-selective antagonist, and showed that it possesses five stereocenters on a 6,5-cis-bicyclo skeleton. Here, we synthesized all the stereoisomers of RK460 and evaluated their activity towards a panel of receptors. Relative stereochemistry as well as absolute stereochemistry was important for selective action.
Welcome to talk about 62-23-7, If you have any questions, you can contact Mikame, Y; Yoshida, K; Hashizume, D; Hirai, G; Nagasawa, K; Osada, H; Sodeoka, M or send Email.. Category: phthalazines
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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem