An article Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis WOS:000472715700003 published article about MYCOBACTERIUM-TUBERCULOSIS; CLINICAL CANDIDATE; DERIVATIVES; DISCOVERY; PYRIDINE; Q203 in [Makane, Vitthal B.; Rode, Haridas B.] CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, Telangana, India; [Makane, Vitthal B.; Krishna, Eruva Vamshi; Misra, Sunil; Rode, Haridas B.] Acad Sci & Innovat Res, Ghaziabad 201002, Uttar Pradesh, India; [Krishna, Vagolu Siva; Sriram, Dharmarajan] Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad Campus, Hyderabad 500078, Telangana, India; [Krishna, Eruva Vamshi; Misra, Sunil] CSIR Indian Inst Chem Technol, Dept Biol, Hyderabad 500007, Telangana, India; [Shukla, Manjulika; Chopra, Sidharth] CSIR Cent Drug Res Inst, Dept Microbiol, Lucknow 226021, Uttar Pradesh, India; [Mahizhaveni, Balakrishnan; Dusthackeer, Vijayan N. Azger] Natl Inst Res TB, Dept Bacteriol, Chennai, Tamil Nadu, India in 2019, Cited 25. Safety of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7
Aim: In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis. Here, we are disclosing the 5-substitued 2-mercapto-1,3,4-oxadiazoles as potent antitubercular agents. Methodology: A small library of 2-mercapto-1,3,4-oxadiazoles was synthesized using various acids. The compounds were evaluated for antituberculosis activity against M. tuberculosis H37Rv. Results: Compound 8j was identified as antitubercular lead with MIC of 0.6g/ml against M. tuberculosis H37Rv. This compound was nontoxic to CHO-K1 cells and showed selectivity index of 39. Of note, 8j showed antitubercular activity against pre-extensively drug-resistant clinical isolate of Mycobacterium with MIC of 2g/ml. Conclusion: This study provides potent antitubercular agent which can be further optimized to discover novel antibiotics. [GRAPHICS] .
Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Makane, VB; Krishna, VS; Krishna, EV; Shukla, M; Mahizhaveni, B; Misra, S; Chopra, S; Sriram, D; Dusthackeer, VNA; Rode, HB or concate me.
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