Category: phthalazines. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells published in 2019.0, Reprint Addresses Pilli, RA (corresponding author), Univ Estadual Campinas, UNICAMP, Inst Chem, Dept Organ Chem, BR-13083970 Campinas, SP, Brazil.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.
Two series of racemic goniothalamin analogues displaying nitrogen-containing groups were designed and synthesized. A total of 19 novel analogues were evaluated against a panel of four different cancer cell lines, along with the normal prostate cell line PNT2 to determine their selectivity. Among them, goniothalamin chloroacrylamide 13 e displayed the lowest IC50 values for both MCF-7 (0.5 mu m) and PC3 (0.3 mu m) cells, about 26-fold more potent than goniothalamin (1). Besides its higher potency, compound 13 e also displayed much higher selectivity than goniothalamin. In contrast, goniothalamin isobutyramide 13 c was the most potent analogue against Caco-2 cells (IC50=0.8 mu m), about 10-fold more potent and 17-fold more selective than 1. These results reveal the potential of compounds 13 c and 13 e for further in vivo studies, representing the first goniothalamin analogues with IC50 values in the low micromolar range and high selectivity against MCF-7, Caco-2, and PC3 cancer cell lines.
About 4-Nitrobenzoic acid, If you have any questions, you can contact Meirelles, MA; Braga, CB; Ornelas, C; Pilli, RA or concate me.. Category: phthalazines
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem