In 2019 EUR J MED CHEM published article about MULTIDRUG-RESISTANT; ANTIMYCOBACTERIAL ACTIVITY; PHARMACOLOGICAL EVALUATION; ANTITUBERCULOSIS ACTIVITY; ANTICANCER ACTIVITY; DERIVATIVES; TUBERCULOSIS; THIADIAZOLES; CYTOTOXICITY; BEDAQUILINE in [Patel, Harun; Jadhav, Harsha; Ansari, Iqrar; Pawara, Rahul; Surana, Sanjay] RC Patel Inst Pharmaceut Educ & Res, Dept Pharmaceut Chem, Shirpur, India in 2019, Cited 33. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4
In the present study, a series of substituted 1,3,4-thiadiazole derivatives 4(a-o), 5(a-m) and 6(a-j) were synthesized and characterized by IR, H-1 NMR, C-13 NMR and mass spectroscopic technique. The synthesized compounds were evaluated for their in vitro anti-mycobacterial activity against the Mycobacterium tuberculosis H37Rv and resistance MDR-TB strain. Among the compounds tested N-(5-(4-nitrophenyl)-1,3,4-thiadiazol-2-yl)furan-2-carboxamide (4h) showed significant inhibitory activity with MIC of 9.87 mu M (H37Rv strain) and 9.87 mu M (MDR-TB strain) compared to isoniazide (MIC of 3.64 mu M (H37Rv) and >200 mu M (MDR-TB strain)] and rifampin [MIC of 0.152 mu M (H37Rv) and 128 mu M (MDR-TB strain)]. In addition, these compounds have also been assessed for their cyto-toxicity to a mammalian Vero cell line using the MTT assay. The result shows that these compounds exhibit anti-tubercular activity at non-cytototoxic concentrations. (C) 2019 Elsevier Masson SAS. All rights reserved.
Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Patel, H; Jadhav, H; Ansari, I; Pawara, R; Surana, S or concate me.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem