Month: October 2021

Recently I am researching about BIOLOGICAL EVALUATION; CATALYTIC INHIBITORS; N-PHENYLPYRROLAMIDES; GYRASE; OPTIMIZATION; DESIGN; POTENT; N-PHENYL-4,5-DIBROMOPYRROLAMIDES; KIBDELOMYCIN; DERIVATIVES, Saw an article supported by the Slovenian Research AgencySlovenian Research Agency – Slovenia [P1-0208]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Skok, Z; Durcik, M; Skledar, DG; Barancokova, M; Masic, LP; Tomasic, T; Zega, A; Kikelj, D; Zidar, N; Ilas, J. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Computed Properties of C7H5NO4

Human DNA topoisomerase II is one of the major targets in anticancer therapy, however ATP-competitive inhibitors of this target have not yet reached their full potential. ATPase domain of human DNA topoisomerase II belongs to the GHKL ATPase superfamily and shares a very high 3D structural similarity with other superfamily members, including bacterial topoisomerases. In this work we report the discovery of a new chemotype of ATP-competitive inhibitors of human DNA topoisomerase II alpha that were discovered through screening of in-house library of ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV. Systematic screening of this library provided us with 20 hit compounds. 1,2,4-Substituted N-phenylpyrrolamides were selected for a further exploration which resulted in 13 new analogues, including 52 with potent activity in relaxation assay (IC50 = 3.2 mu M) and ATPase assay (IC50 = 0.43 mu M). Cytotoxic activity of all hits was determined in MCF-7 cancer cell line and the most potent compounds, 16 and 20, showed an IC50 value of 8.7 and 8.2 mu M, respectively.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Skok, Z; Durcik, M; Skledar, DG; Barancokova, M; Masic, LP; Tomasic, T; Zega, A; Kikelj, D; Zidar, N; Ilas, J or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines. I found the field of Chemistry very interesting. Saw the article Copper-Catalyzed Four-Component Reaction for the Synthesis of N-Difluoroethyl Imides published in 2019, Reprint Addresses Hu, XG (corresponding author), Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China.; Hu, XG (corresponding author), Jiangxi Normal Univ, Key Lab Small Funct Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A general and efficient method for the synthesis N-difluoroethyl imides has been developed. This copper-catalyzed four-component reaction proceeds via in-situ generated difluorodiazomethane, which does not require prior formation and transferring. The reaction is scalable, tolerant toward a range of functional groups, and also suitable for the late-stage functionalization of drugs and drug-like molecules.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Gao, Y; Peng, SQ; Liu, DY; Rui, PX; Hu, XG or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 J MATER CHEM A published article about METAL-ORGANIC FRAMEWORK; NITRO-COMPOUNDS; P-NITROPHENOL; COPPER NANOPARTICLES; MODEL REACTION; REDUCTION; CARBON; SIZE; NANOCOMPOSITE; GREEN in [Sorenson, Anh H. T. Nguyen; Orcutt, Emma K.; Anderson, Hans C.; Stowers, Kara J.] Brigham Young Univ, Dept Chem, Provo, UT 84604 USA; [Sorenson, Anh H. T. Nguyen; Orcutt, Emma K.; Anderson, Hans C.; Stowers, Kara J.] Brigham Young Univ, Biochem Dept, Provo, UT 84604 USA; [Kent, Rosalyn, V; Matzger, Adam J.] Univ Michigan, Dept Chem, 930 North Univ Ave, Ann Arbor, MI 48109 USA; [Kent, Rosalyn, V; Matzger, Adam J.] Univ Michigan, Macromol Sci & Engn Program, 930 North Univ Ave, Ann Arbor, MI 48109 USA; [Wu, Yu] Sichuan Univ Sci & Engn, Coll Chem & Environm Engn, Zigong 643000, Peoples R China in 2020.0, Cited 73.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

Metal-organic frameworks (MOFs) have recently emerged as efficient self-sacrificial templates to fabricate porous carbon-supported metal nanoparticles (NPs). Due to observed increased activity, catalysts containing bimetallic NPs represent an active frontier for heterogeneous catalyst development. A strategy to synthesize active catalysts with highly dispersed bimetallic metal/metal oxides within a porous carbon matrixviarapid MOF decomposition using dopants is presented in this paper. A 2,4,6-trinitrotoluene (TNT) additive enhances the rapid thermolysis of the metal-doped Cu-based MOFs to minimize particle aggregation. Catalyst characterization reveals that a secondary metal increases dispersion of both metals over the carbon composite support. The catalyst preparation method influences both the metal particle size and oxidation state. Catalytic performance shows increased rates for 4-nitrophenol reduction even with <1 wt% of added secondary metal. Among the synthesized catalysts, the Ni-CuO@C bimetallic catalyst exhibits outstanding activity. This synthetic strategy is useful for creating highly efficient, robust, non-noble metal catalysts for development of sustainable chemical processes. About 4-Nitrobenzoic acid, If you have any questions, you can contact Sorenson, AHTN; Wu, Y; Orcutt, EK; Kent, RV; Anderson, HC; Matzger, AJ; Stowers, KJ or concate me.. COA of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 J CATAL published article about EFFICIENT CARBOCATALYST; ORGANIC POLLUTANTS; CARBON NANOTUBES; GRAPHENE OXIDE; REDUCTION; NITROGEN; NANOPARTICLES; OXIDATION; 4-NITROPHENOL; DEGRADATION in [He, Zhaolin; Liu, Jin; Zhao, Wang; Wen, Zhipan; Chen, Jun; Xi, Jiangbo; Yu, Junxia; Bai, Zhengwu] Wuhan Inst Technol, Sch Chem & Environm Engn, Wuhan 430073, Hubei, Peoples R China; [Wang, Qijun; Manoj, Devaraj; Xie, Chuyi; Wang, Shuai] Huazhong Univ Sci & Technol, Sch Chem & Chem Engn, Key Lab Mat Chem Energy Convers & Storage, Minist Educ, Wuhan 430074, Hubei, Peoples R China; [Tang, Chunyan] Guangxi Univ, Sch Comp Elect & Informat, Nanning 530004, Guangxi, Peoples R China in 2019.0, Cited 53.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4

Eco-friendly carbocatalyst is extremely desirable in organic catalysis and wastewater treatment. Herein, we reported a one-pot synchronous hydrothermal process to synthesize a highly efficient N doped holey graphene (NHG) carbocatalyst, in which graphene oxide nanosheets are self-assembled, reduced, chemically etched, and simultaneously doped with nitrogen to form a graphene hydrogel in the presence of H2O2 and NH4OH. Benefiting from the good hydrophilicity, unique hierarchical porous structure, large specific surface area (322.1 m(2)g(-1)), and high N content (9.77 at. %), the resultant NHG carbocatalyst exhibits an excellent catalytic performance for the hydrogenation of N-containing unsaturated compounds. In 4-nitrophenol reduction reaction, the NHG carbocatalyst delivers a turnover frequency of 3.32 x 10(-2) min(-1). This catalytic activity is superior to that of the commercial Pd/C (5.0 wt%), other previously reported carbocatalysts, and many noble-metal-based catalysts. Furthermore, the molecular structure analysis combined with density functional theory calculations elucidate metal-free catalytic mechanism of hydrogenation reaction for unsaturated chromophore groups in N-containing organic dyes. (C) 2019 Elsevier Inc. All rights reserved.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact He, ZL; Liu, J; Wang, QJ; Zhao, W; Wen, ZP; Chen, J; Manoj, D; Xie, CY; Xi, JB; Yu, JX; Tang, CY; Bai, ZW; Wang, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of Functionalised Chromonyl-pyrimidines and Their Potential as Antimycobacterial Agents WOS:000529295500032 published article about II NADH DEHYDROGENASE; DERIVATIVES; OXIDOREDUCTASE; ACTIVATION; INHIBITORS; SERIES in [Santoso, Kristiana T.; Brett, Matthew W.; Stocker, Bridget L.; Timmer, Mattie S. M.] Victoria Univ Wellington, Sch Chem & Phys Sci, POB 600, Wellington 6140, New Zealand; [Santoso, Kristiana T.; Brett, Matthew W.; Stocker, Bridget L.; Timmer, Mattie S. M.] Victoria Univ Wellington, Ctr Biodiscovery, POB 600, Wellington 6140, New Zealand; [Santoso, Kristiana T.; Cook, Gregory M.; Stocker, Bridget L.; Timmer, Mattie S. M.] Univ Auckland, Maurice Wilkins Ctr Mol Biodiscovery, Auckland, New Zealand; [Cheung, Chen-Yi; Cook, Gregory M.] Univ Otago, Dept Microbiol & Immunol, Sch Biomed Sci, Dunedin, New Zealand in 2020, Cited 39. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Drug-resistant strains of Mycobacterium tuberculosis are on the rise and have resulted in an urgent need to develop new tuberculosis (TB) drugs. Herein, the development of chromonyl-pyrimidines as a new TB drug scaffold is presented. A library of eleven chromonyl-pyrimidines was synthesised, from which lead compound 6-((2-amino-6-methylpyrimidin-4-yl)amino)-3-benzoyl-2-phenyl-4H-chromen-4-one (MIC=36 mu M against M. tuberculosis) was identified. A second-generation library of seven aryl-substituted chromonyl-pyrimidines was then prepared, with six chromonyl-pyrimidines exhibiting an improved M. tuberculosis growth inhibition (MIC=12.5 mu M). From this work, the potential of chromonyl-pyrimidines as therapeutics for TB is demonstrated.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Santoso, KT; Brett, MW; Cheung, CY; Cook, GM; Stocker, BL; Timmer, MSM or concate me.. HPLC of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 ORG CHEM FRONT published article about FLUORINE; ACTIVATION; ARENES; TRIFLUOROETHYLATION; PHARMACEUTICALS; HETEROARENES in [Liu, Xiaochong; Mao, Guijie; Qiao, Jingyi; Xu, Chunzhao; Liu, Hao; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi] Heilongjiang Univ, Sch Chem & Mat Sci, Harbin 150080, Heilongjiang, Peoples R China; [Liu, Xiaochong; Qiao, Jingyi; Xu, Chunzhao; Liu, Hao; Ma, Junjie; Sun, Zhizhong; Chu, Wenyi] Coll Heilongjiang Prov, Key Lab Chem Engn Proc & Technol High Efficiency, Harbin 150080, Heilongjiang, Peoples R China in 2019, Cited 37. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

A Ni(TFA)(2)-catalyzed ortho-trifluoromethylation of 8-aminoquinoline derivatives was developed by acyl-directed C-H functionalization. A series of 7-trifluoromethylquinolinamine derivatives were originally obtained with moderate to excellent yields by using TMSCF3 as the trifluoromethylation reagent under mild conditions. In addition, the reaction mechanism is proposed and proved by the related experiment.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Liu, XC; Mao, GJ; Qiao, JY; Xu, CZ; Liu, H; Ma, JJ; Sun, ZZ; Chu, WY or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Liu, Y; Zhang, JY; Feng, SY; Zhao, TL; Li, ZZ; Wang, L; Wang, PH; Du, HZ; Yuan, ST; Sun, L in [Liu, Yang; Zhao, Tingli; Wang, Lai; Du, Hongzhi; Sun, Li] China Pharmaceut Univ, Jiangsu Key Lab Drug Screening, 24 Tongjiaxiang, Nanjing, Jiangsu, Peoples R China; [Zhang, Jingyin] Southeast Univ, Dept Gynaecol & Obstet, Affiliated Zhongda Hosp, Nanjing, Jiangsu, Peoples R China; [Feng, Shuyun; Li, Zhengzheng; Yuan, Shengtao] China Pharmaceut Univ, Jiangsu Ctr Pharmacodynam Res & Evaluat, 24,Tongjiaxiang, Nanjing, Jiangsu, Peoples R China; [Wang, Puhai] Nanjing Technol Univ, Jiangsu Prov Inst Materia Med, Nanjing, Jiangsu, Peoples R China published A Novel Camptothecin Derivative 3j Inhibits NSCLC Proliferation via Induction of Cell Cycle Arrest by Topo I-Mediated DNA Damage in 2019, Cited 40. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Objective: The aim of this study is to investigate the inhibitory effect of camptothecin derivative 3j on Non-Small Cell Lung Cancer (NSCLCs) cells and the potential anti-tumor mechanisms. Background: Camptothecin compounds are considered as the third largest natural drugs which are widely investigated in the world and they suffered restriction because of serious toxicity, such as hemorrhagic cystitis and bone marrow suppression. Methods: Using cell proliferation assay and S180 tumor mice model, a series of 20(S)-O-substituted benzoyl 7-ethylcamptothecin compounds were screened and evaluated the antitumor activities in vitro and in vivo. Camptothecin derivative 3j was selected for further study using flow cytometry in NSCLCs cells. Cell cycle related protein cyclin A2, CDK2, cyclin D and cyclin E were detected by Western Blot. Then, computer molecular docking was used to confirm the interaction between 3j and Topo L Also, DNA relaxation assay and alkaline cornet assay were used to investigate the mechanism of 3j on DNA damage. Results: Our results demonstrated that camptothecin derivative 3j showed a greater antitumor effect in eleven 20(S)-O-substituted benzoyl 7-ethylcamptothecin compounds in vitro and in vivo. The IC50 of 3j was 1.54 +/- 0.41 mu M lower than irinotecan with an IC50 of 13.86 +/- 0.80 mu M in NCI-H460 cell, which was reduced by 8 fold. In NCI-H1975 cell, the IC50 of 3j was 1.87 +/- 0.23 mu M lower than irinotecan (IC50 +/- SD, 5.35 +/- 0.38 mu M), dropped by 1.8 fold. Flow cytometry analysis revealed that 3j induced significant accumulation in a dose-dependent manner. After 24h of 3j (10 mu M)treatment, the percentage of NCI-H460 cell in S-phase significantly increased (to 93.54 +/- 4.4%) compared with control cells (31.67 +/- 3.4%). Similarly, the percentage of NCI-H1975 cell in S-phase significantly increased (to 83.99 +/- 2.4%) compared with control cells (34.45 +/- 3.9%) after treatment with 10 mu M of 3j. Moreover, increased levels of cyclin A2, CDK2, and decreased levels of cyclin D, cyclin E further confirmed that cell cycle arrest was induced by 3j. Furthermore, molecular docking studies suggested that 3j interacted with Topo I-DNA and DNA-relaxation assay simultaneously confirmed that 3j suppressed the activity of Topo I. Research on the mechanism showed that 3j exhibited anti-tumour activity via activating the DNA damage response pathway and suppressing the repair pathway in NSCLC cells. Conclusion: Novel camptothecin derivative 3j has been demonstrated as a promising antitumor agent and remains to be assessed in further studies.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Liu, Y; Zhang, JY; Feng, SY; Zhao, TL; Li, ZZ; Wang, L; Wang, PH; Du, HZ; Yuan, ST; Sun, L or concate me.. Quality Control of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about ALIPHATIC CARBOXYLIC-ACIDS; HYDROGEN-ATOM TRANSFER; DECARBOXYLATIVE FLUORINATION; DEOXYFLUORINATION; LIGHT; ALCOHOLS; ACTIVATION, Saw an article supported by the . Published in SCIENCE PRESS in BEIJING ,Authors: Ma, JY; Xu, WT; Xie, J. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. COA of Formula: C7H5NO4

In this communication, we disclose the first example of metal-free and site-selective radical fluorination of readily available tertiary alkyl ethers, enabled by synergistic photocatalysis and organocatalysis. This catalytic combination allows for exclusive fluorination of tertiary C-O bonds under mild conditions even in the presence of competing reaction sites. The excellent functional group tolerance affords valuable access to sterically hindered alkyl fluorides through late-stage modification of complex molecules. The successful use of tertiary alkyl ethers in radical fluorination enhances the structural diversity of aliphatic fluorides that can be derived from naturally abundant alcohols.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, JY; Xu, WT; Xie, J or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines. I found the field of Chemistry very interesting. Saw the article Solvent- and metal-free hydroboration of alkynes under microwave irradiation published in 2020, Reprint Addresses Rocheblave, L (corresponding author), Univ Lyon, Univ Claude Bernard Lyon 1, ISPB Fac Pharm, EA 4446,B2MC, F-69373 Lyon 08, France.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Boronic esters are versatile building blocks extensively used in organic chemistry and essential to a variety of coupling reactions. In this work, the hydroboration reactions of alkynes were performed without metal catalysts using concomitant microwave irradiation that allowed a significantly reduced reaction time. Another interesting outcome of this study was that the reaction could be carried out under solvent-free conditions, highlighting the environmentally-friendly nature of our method. A wide scope of aryl- and alkylboronic acid pinacol esters were easily synthesized from the corresponding alkynes. (C) 2020 Elsevier Ltd. All rights reserved.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Gioia, B; Arnaud, A; Radix, S; Walchshofer, N; Doleans-Jordheim, A; Rocheblave, L or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Cheng, WF; Chen, LY; Xu, FF; Lin, WY; Ren, XR; Li, Y in ROYAL SOC CHEMISTRY published article about DIELS-ALDER REACTIONS; MANNICH-TYPE REACTION; ENANTIOSELECTIVE CONSTRUCTION; QUATERNARY; STEREOCENTERS; 2-OXINDOLES; SCAFFOLD; BEARING; DESIGN; JOINS in [Cheng, Wen-Fu; Chen, Ling-Yan; Xu, Fang-Fang; Lin, Wei-Yu; Ren, Xinfeng; Li, Ya] Shanghai Univ Engn Sci, Coll Chem & Chem Engn, 333 Longteng Rd, Shanghai 201620, Peoples R China in 2019.0, Cited 50.0. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Organocatalytic asymmetric Michael addition between 3-substituted oxindoles and enals catalyzed by chiral camphor sulfonyl hydrazines (CaSHs) has been developed. A wide range of 3-substituted oxindoles and enals were successfully used, giving the corresponding 3,3-disubstituted oxindoles containing vicinal stereogenic carbon centers in good yields with good to excellent enantioselectivities and moderate to good diastereoselectivities (up to 89% yield, 99% ee and 99 : 1 dr).

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Cheng, WF; Chen, LY; Xu, FF; Lin, WY; Ren, XR; Li, Y or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem