Month: October 2021

Recently I am researching about ANTICANCER ACTIVITY; TRIAZOLE DERIVATIVES; MOLECULAR DOCKING; IN-VITRO; SULFATE, Saw an article supported by the Center with Potential for Excellence in a Particular Area; UGCUniversity Grants Commission, India; ISF-UGC [6-6/2016(IC)]. Published in BENTHAM SCIENCE PUBL LTD in SHARJAH ,Authors: Hari, S; Swaroop, TR; Preetham, HD; Mohan, CD; Muddegowda, U; Basappa, S; Vlodavsky, I; Sethi, G; Rangappa, KS. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Safety of 4-Nitrobenzoic acid

Design of chemically novel, biologically potent small heterocyclic molecules with anticancer activities, which targets the enzyme heparanase has gained prominent clinical interest. We have synthesized a novel class of carboxamide derivatives by coupling various substituted aromatic acid hydrazides and triazoleamine with pyrrolidine carboxylic acid by using coupling agents. The synthesized compounds are characterized by spectroscopic techniques such as FT-IR, DIMS and NMR. These compounds arc investigated for cytotoxicity on different cancer cell lines and heparanase inhibitory activity. Most of them showed moderate heparanase inhibitory activity and good cytotoxicity.

Welcome to talk about 62-23-7, If you have any questions, you can contact Hari, S; Swaroop, TR; Preetham, HD; Mohan, CD; Muddegowda, U; Basappa, S; Vlodavsky, I; Sethi, G; Rangappa, KS or send Email.. Safety of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 EUR J MED CHEM published article about SM PROTEINS; PRMT5; METHYLATION; GROWTH; IDENTIFICATION; COMPLEX; PICLN in [Shao, Jingwei; Duan, Wenhu] Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, Shanghai 201203, Peoples R China; [Zhu, Kongkai; Tao, Hongrui] Univ Jinan, Sch Biol Sci & Technol, Jinan 250022, Shandong, Peoples R China; [Du, Daohai; Zhang, Yuanyuan; Tao, Hongrui; Chen, Zhifeng; Jiang, Hualiang; Chen, Kaixian; Luo, Cheng] Chinese Acad Sci, Shanghai Inst Mat Med, Drug Discovery & Design Ctr, CAS Key Lab Receptor Res,State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China; [Chen, Kaixian; Luo, Cheng] Qingdao Natl Lab Marine Sci & Technol, Open Studio Drugabil Res Marine Nat Prod, Wenhai Rd, Qingdao 266237, Shandong, Peoples R China in 2019, Cited 36. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

Protein arginine methyltransferases 5 (PRMT5) represents an attractive drug target in epigenetic field for the treatment of leukemia and lymphoma. Here, a series of N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)amide derivatives targeting PRMT5 were designed with structure-based approach and synthesized. Among them, compound 46 showed potent and selective PRMT5 inhibition activity with an IC50 of 8.5 nM, which was approximately equivalent with the phase 1 clinical trial PRMT5 inhibitor GSK-3326595 (IC50 = 5.5 nM). Compound 46 also displayed pronounced anti-proliferative activity in MV4-11 cells (GI(50) =18 nM) and antitumor activity in MV4-11 mouse xenografts model. This molecule can serve as an excellent tool compound for probing the biological function of PRMT5. (C) 2018 Published by Elsevier Masson SAS.

Welcome to talk about 62-23-7, If you have any questions, you can contact Shao, JW; Zhu, KK; Du, DH; Zhang, YY; Tao, HR; Chen, ZF; Jiang, HL; Chen, KX; Luo, C; Duan, WH or send Email.. Recommanded Product: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. Recently I am researching about ASYMMETRIC REDUCTION; CARBONYL REDUCTASE; DERIVATIVES; CONVERSION; ALCOHOLS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21801047]; Shanghai Sailing Program [18YF1402100]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Wang, ZX; Wu, XF; Li, ZN; Huang, ZD; Chen, F. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

We report here the stereoselective bioreduction of -nitro ketones catalyzed by ketoreductases (KREDs) with publicly known sequences. YGL039w and RasADH/SyADH were able to reduce 23 class I substrates (1-aryl-2-nitro-1-ethanone (1)) and ten class II substrates (1-aryloxy-3-nitro-2-propanone (4)) to furnish both enantiomers of the corresponding -nitro alcohols, with good-to-excellent conversions (up to >99%) and enantioselectivities (up to >99% ee) being achieved in most cases. To the best of our knowledge, KRED-mediated reduction of class II -nitro ketones (1-aryloxy-3-nitro-2-propanone (4)) is unprecedented. Select -nitro alcohols, including the synthetic intermediates of bioactive molecules (R)-tembamide, (S)-tembamide, (S)-moprolol, (S)-toliprolol and (S)-propanolol, were stereoselectively synthesized in preparative scale with 42% to 90% isolated yields, showcasing the practical potential of our developed system in organic synthesis. Finally, the advantage of using KREDs with known sequence was demonstrated by whole-cell catalysis, in which -nitro alcohol (R)-2k, the key synthetic intermediate of hypoglycemic natural product (R)-tembamide, was produced in a space-time yield of 178 g L-1 d(-1) as well as 95% ee by employing the whole cells of a recombinant E. coli strain coexpressing RasADH and glucose dehydrogenase as the biocatalyst.

Welcome to talk about 62-23-7, If you have any questions, you can contact Wang, ZX; Wu, XF; Li, ZN; Huang, ZD; Chen, F or send Email.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Silica catalyzed one pot synthesis of hybrid thiazolidin-4-one derivatives as anti-tubercular and anti-inflammatory agent by attenuating COX-2 pathway WOS:000479497800001 published article about MOLECULAR DOCKING; STROKE RISK; 1,3,4-THIADIAZOLE; NSAIDS in [Pathak, Prateek; Naumovich, Vladislav; Grishina, Maria; Potemkin, Vladimir] South Ural State Univ, Higher Med & Biol Sch, Lab Modeling Drugs, Tchaikovsky Str 20-A, Chelyabinsk 454008, Russia; [Shukla, Parjanya Kumar; Verma, Amita] Sam Higginbottom Univ Agr Technol & Sci, Fac Hlth Sci, Dept Pharmaceut Sci, Bioorgan & Med Chem Res Lab, Allahabad 211007, Uttar Pradesh, India; [Shukla, Parjanya Kumar] Uttar Pradesh Tech Univ, Krishnarpit Inst Pharm, Allahabad, Uttar Pradesh, India in 2019, Cited 49. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

A novel series of a hybrid class of hybrid thiazolidin-4-one derivatives were designed and synthesized through one-pot catalytic synthesis. The reaction was catalyzed in the presence of silica-H(2)SO4((+6)). The derivatives computational ADMET profile was calculated. The study shows that most active derivatives have optimal logP, higher anti-inflammatory activity score, and poor metabolism at the sight of P450-3A4 and 2D6. The entire series of derivatives were further evaluated for anti-tubercular (against Mycobacterium tuberculosis H37Rv (Resistant strain)) and anti-inflammatory activity (in-vivo assay using Wistar rat). The result showed that derivatives 4c, 4h, and 4m have significant potency against tested M. tuberculosis. However, derivatives 4i and 4j found significantly active against inflammation. In vitro COX inhibition assay also supported the result in favor of selectivity and efficacy of derivatives. [GRAPHICS] .

Welcome to talk about 62-23-7, If you have any questions, you can contact Pathak, P; Shukla, PK; Naumovich, V; Grishina, M; Potemkin, V; Verma, A or send Email.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM in AMER CHEMICAL SOC published article about ALLYLIC ALKYLATIONS; BOND ACTIVATION; FUNCTIONALIZATION; ALLYLATION; ALKENES; ARYLATION; ACETATES; SP(3) in [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Adv Res Inst, Taizhou 318000, Peoples R China; [Sun, Manman; Chen, Weida; Xia, Xiangyu; Ma, Yongmin; Yang, Jianguo; Wang, Zhiming] Taizhou Univ, Dept Chem, Taizhou 318000, Peoples R China; [Shen, Guodong] Liaocheng Univ, Sch Chem & Chem Engn, Sch Pharm, Liaocheng 252000, Shandong, Peoples R China; [Ding, Hanfeng] Zhejiang Univ, Dept Chem, Hangzhou 310058, Peoples R China in 2020, Cited 82. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A palladium-catalyzed tandem dehydrogenative [4 + 2] annulation of terminal olefins with N-sulfonyl amides via C(sp(2))-H activation, allylic C(sp(3))-H activation, and homoallylic C(sp(3))-H elimination processes has been developed. Promoted by the DMSO ligand, various benzamides, heterocyclic arylamides, alkenyl carboxamides, and commercial olefins are found to be efficient substrates to construct important heterocyclic compounds bearing a vinyl substituent with high E stereoselectivity. Using air as the terminal oxidant also provides a great advantage regarding environmental friendliness.

Welcome to talk about 62-23-7, If you have any questions, you can contact Sun, MM; Chen, WD; Xia, XY; Shen, GD; Ma, YM; Yang, JG; Ding, HF; Wang, ZM or send Email.. Category: phthalazines

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 J ORG CHEM published article about EFFICIENT SYNTHESIS; N-ALKYLATION; SOLVENT-FREE; REDUCTIVE FUNCTIONALIZATION; KETONE SYNTHESIS; BOND FORMATION; AMINES; ALDEHYDES; ESTERS; THIOESTERS in [Xuan, Maojie; Liu, Meina] Shanghai Inst Technol, Sch Chem & Environm Engn, Shanghai 201418, Peoples R China; [Xuan, Maojie; Lu, Chunlei; Lin, Bo-Lin] ShanghaiTech Univ, SPST, Shanghai 201210, Peoples R China; [Lu, Chunlei; Lin, Bo-Lin] Chinese Acad Sci, Shanghai Inst Organ Chem, Shanghai 200032, Peoples R China in 2019, Cited 63. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. SDS of cas: 62-23-7

Direct thioesterification of carboxylic acids with thiols using nontoxic activation agents is highly desirable. Herein, an efficient and practical protocol using safe and inexpensive industrial waste polymethylhydrosiloxane as the activation agent and K3PO4 with 18-crown-6 as a catalyst is described. Various functional groups on carboxylic acid and thiol substituents can be tolerated by the present system to afford thioesters in yields of 19-100%.

Welcome to talk about 62-23-7, If you have any questions, you can contact Xuan, MJ; Lu, CL; Liu, MN; Lin, BL or send Email.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Semi-synthesis and anti-tumor activity of novel 25-OCH3-PPD derivatives incorporating aromatic moiety WOS:000454616600012 published article about IN-VITRO; NATURAL-PRODUCT; PANAX-GINSENG; CANCER; GINSENOSIDES; 20(S)-25-METHOXYL-DAMMARANE-3-BETA; 20-TRIOL; 12-BETA; VIVO in [Qu, Fan-Zhi; Xiao, Sheng-Nan; Wang, Xu-De; Zhang, Yan; Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China; [Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China in 2019, Cited 26. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Previously we have reported that 25-OCH3-PPD could suppress the reproduction of cancer cells and cause apoptosis without obvious toxicity. Herein, we aimed to enhance its bioactivity by introducing aromatic groups to its dammarane-type skeleton. These synthesized derivatives were tested for their inhibitory activities against five cancer cell lines. Of them, compounds 3a, 14a and 18a had the strongest antiproliferative activities against tumor cells (IC50 < 15 mu M, 5-fold to 10-fold increases than 25-OCH3-PPD). Especially compound 14a displayed the most potent activity against DU145, MCF-7 and HepG2 cells (IC50 = 6.7 +/- 0.8, 4.3 +/- 0.8 and 5.8 +/- 0.6 mu M, respectively). Structure-activity relationships demonstrated that having aromatic ester at the C3 position could improve the bioactivity. The data provided new insights into exploring novel antiproliferative lead compounds. Welcome to talk about 62-23-7, If you have any questions, you can contact Qu, FZ; Xiao, SN; Wang, XD; Zhang, Y; Su, GY; Zhao, YQ or send Email.. Quality Control of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 CHEMISTRYSELECT published article about BIOLOGICAL EVALUATION; PHARMACOLOGICAL-ACTIVITIES; INHIBITORS; POTENT; TRIAZOLOTHIADIAZINES; THIENOPYRIMIDINES; 1,2,4-TRIAZOLES; THIADIAZOLES; THIOPHENE in [Settypalli, Triloknadh; Chunduri, Venkata Rao; Kerru, Nagaraju; Nallapaneni, Hari Krishna] Sri Venkateswara Univ, Dept Chem, Tirupati 517502, Andhra Pradesh, India; [Chintha, Venkata Ramaiah; Daggupati, Trinath; Yeguvapalli, Suneetha; Wudayagiri, Rajendra] Sri Venkateswara Univ, Dept Zool, Tirupati 517502, Andhra Pradesh, India in 2019, Cited 55. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 4-Nitrobenzoic acid

In pursuit of neuroprotective and antimicrobial agents, a series of 1,2,4-triazolo[3,4-b]1,3,4-thiadiazole incorporated thieno[2,3-d]pyrimidine derivatives 10 a-l has been designed, synthesized. The final target compounds were screened for neuroprotective, neurotoxic and antibacterial activities. The compounds derived from 4-methylphenyl (10 a) and 4-nitrophenyl (10 c) have showed good neuroprotective activity against H2O2 induced PC12 cell death at respective EC50 values of 10.44, 14.12 mu g/mL. However 10 b and 10 k showed superior neurotoxic effects than rest of the compounds with respective CC50 values of 100.16, 120 mu g/mL. Potent antibacterial activity was shown by 10 f (R=-Me, R-2=-OMe), 10 h (R=-Me, R-2=-Cl) against the four bacterial pathogens such as S.aureus, B.subtilis, E.coli and P.aeruginosa at low minimum inhibitory concentration (MIC) range. Further, in silico docking studies were performed for all the synthesized compounds with C(30) carotenoid dehydrosqualene synthase, Gyrase A and LpxC bacterial proteins. Interestingly, 10 f, 10 h showed good binding affinities with target proteins and these results are in good compliance with the in vitro activity profile data.

Welcome to talk about 62-23-7, If you have any questions, you can contact Settypalli, T; Chunduri, VR; Kerru, N; Nallapaneni, HK; Chintha, VR; Daggupati, T; Yeguvapalli, S; Wudayagiri, R or send Email.. Recommanded Product: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Ultrasound-Assisted Synthesis of N -Acylcyanamides and N -Acyl-Substituted Imidazolones from Carboxylic Acids by Using Trichloroisocyanuric Acid/Triphenylphosphine WOS:000526694900012 published article about CATALYZED CARBONYLATIVE SYNTHESIS; FACILE SYNTHESIS; CYANAMIDES; INHIBITORS; POTENT; TRIPHENYLPHOSPHINE; ISOTHIOCYANATES; QUINAZOLINONES; TRANSFORMATION; LEUCETTINES in [Phakhodee, Wong; Yamano, Dolnapa; Pattarawarapan, Mookda] Chiang Mai Univ, Fac Sci, Dept Chem, Chiang Mai 50200, Thailand; [Phakhodee, Wong; Yamano, Dolnapa; Pattarawarapan, Mookda] Chiang Mai Univ, Fac Sci, Ctr Excellence Innovat Chem, Chiang Mai 50200, Thailand; [Phakhodee, Wong; Pattarawarapan, Mookda] Chiang Mai Univ, Fac Sci, Res Ctr Chem Dev Hlth Promoting Prod Northern Res, Chiang Mai 50200, Thailand in 2020, Cited 46. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A convenient ultrasound-assisted one-pot synthesis of N -acylcyanamides starting from readily available carboxylic acids and sodium cyanamide has been developed. Upon activation in the presence of trichloroisocyanuric acid (TCCA) and triphenylphosphine, a range of carboxylic acids was converted into N -acylcyanamides in good to excellent yields within 10 minutes at room temperature without base. Remarkably, N -acyl-substituted imidazolones were readily accessible through guanylation-cyclization of the in situ generated N -acylcyanamides.

Welcome to talk about 62-23-7, If you have any questions, you can contact Phakhodee, W; Yamano, D; Pattarawarapan, M or send Email.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Dolui, P; Hazra, S; Deb, M; Elias, AJ in AMER CHEMICAL SOC published article about CARBOXYLIC-ACID SALTS; CP-H BONDS; PRIMARY ALCOHOLS; UNACTIVATED C(SP(3))-H; AEROBIC OXIDATION; WATER; AMINES; ESTERIFICATION; ALKYLATION; CONVERSION in [Dolui, Pritam; Hazra, Susanta; Deb, Mayukh; Elias, Anil J.] Indian Inst Technol, Dept Chem, New Delhi 110016, India in 2019.0, Cited 68.0. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Picolinamide group assisted sp(3) C-H bond oxidation of methylene groups to the corresponding carbonyl compounds has been achieved by using simple bottle ferrocene as catalyst and Cu(OAc)(2) or tert-butyl peroxybenzoate (TBPB) as oxidant under mild conditions. This method is applicable for picolinamide bound organic as well as organometallic compounds with yields in the range of 46-82%. Control experiments and mechanistic studies indicate that a radical mechanism is responsible for these oxidative transformations in which ferrocene acts as a catalyst.

Welcome to talk about 62-23-7, If you have any questions, you can contact Dolui, P; Hazra, S; Deb, M; Elias, AJ or send Email.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem