Month: October 2021

Recommanded Product: 4-Nitrobenzoic acid. Wang, D; Lu, B; Song, YL; Sun, HM; Shen, Q in [Wang, Dan; Lu, Bing; Song, Yan-Ling; Sun, Hong-Mei; Shen, Qi] Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Peoples R China published Fe(III)-catalyzed oxidative coupling of alkylnitriles with aromatic carboxylic acids: Facile access to cyanomethyl esters in 2019, Cited 78. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The first oxidative coupling of alkylnitriles with aromatic carboxylic acids using di-tert-butyl peroxide (DTBP) as oxidant was achieved under the catalysis of ionic Fe(III) complexes bearing an imidazolinium cation. This protocol features nontoxic iron catalysis, direct alpha-C(sp(3))-H bond oxidative esterification of alkylnitriles, non-prefunctionalized starting materials, and a broad substrate scope with outstanding steric hindrance tolerance, providing a novel, straightforward, and green approach toward cyanomethyl ester synthesis. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, D; Lu, B; Song, YL; Sun, HM; Shen, Q or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. In 2019.0 CHEMCATCHEM published article about CHEMOSELECTIVE HYDROGENATION; PD NANOPARTICLES; NITRO-COMPOUNDS; REDUCTION; PERFORMANCE; NITROAROMATICS; EXPLORATION; INTERFACES; HYDRAZINE; COMPOSITE in [Tian, Haimeng; Li, Yunong; Wang, Yiming; Liu, Lei; Hu, Ze-Nan; Li, Jifan; Guo, Rongxiu; Liu, Zhibo; Sun, Hong-bin] Northeastern Univ, Dept Chem, Shenyang 110819, Liaoning, Peoples R China; [Zhou, Junjie] Tsinghua Univ, Dept Elect Engn, Beijing 100084, Peoples R China; [Ai, Yongjian; Liang, Qionglin] Tsinghua Univ, Ctr Synthet & Syst Biol, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Dept Chem,Minist Educ, Beijing 100084, Peoples R China in 2019.0, Cited 55.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Modifying the surface of metal catalyst is a crucial subject for improving the heterogeneous metal catalysts. It is still a great challenge to understand the structure-activity relationship (SAR) between the surface supporting groups and the metal particles. Herein, Rh NPs supported on the magnetic silica sphere with various functional groups (-NH2, -SH, -SO3H, -N=CH2, -Cl, -NHCOCH3 and -NHCH2Ph) have been prepared for catalytic hydrogenation of nitroarenes under atmospheric pressure at room temperature. We discover that the chemical state of Rh NPs depends on the supporting groups significantly. The electron-donating functionalities can effectively elevate the Rh-0/Rh3+ ratio, which increase the catalytic performance both in conversion and selectivity. The amino group decorated catalyst has such a good selectivity that no dechlorination reaction is observable in the hydrogenation of 2-chloro-3-nitropyridine. What’s more, by introducing magnetic Fe3O4 nuclei and mesoporous silica encapsulating layer, the catalyst can be recovered conveniently by an external magnet, and can be reused 10 cycles without any loss of activity.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Tian, HM; Zhou, JJ; Li, YN; Wang, YM; Liu, L; Ai, YJ; Hu, ZN; Li, JF; Guo, RX; Liu, ZB; Sun, HB; Liang, QL or concate me.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Helman, G; Patlewicz, G; Shah, I in ACADEMIC PRESS INC ELSEVIER SCIENCE published article about in [Helman, G.] ORISE, Oak Ridge, TN USA; [Helman, G.; Patlewicz, G.; Shah, I] US Environm Protect Agcy, Natl Ctr Computat Toxicol, Off Res & Dev, Res Triangle Pk, NC USA in 2019.0, Cited 35.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Computational approaches have recently gained popularity in the field of read-across to automatically fill data-gaps for untested chemicals. Previously, we developed the generalized read-across (GenRA) tool, which utilizes in vitro bioactivity data in conjunction with chemical descriptor information to derive local validity domains to predict hazards observed in in vivo toxicity studies. Here, we modified GenRA to quantitatively predict point of departure (POD) values obtained from US EPA’s Toxicity Reference Database (ToxRefDB) version 2.0. To evaluate GenRA predictions, we first aggregated oral Lowest Observed Adverse Effect Levels (LOAEL) for 1,014 chemicals by systemic, developmental, reproductive, and cholinesterase effects. The mean LOAEL values for each chemical were converted to log molar equivalents. Applying GenRA to all chemicals with a minimum Jaccard similarity threshold of 0.05 for Morgan fingerprints and a maximum of 10 nearest neighbors predicted systemic, developmental, reproductive, and cholinesterase inhibition min aggregated LOAEL values with R-2 values of 0.23, 0.22, 0.14, and 0.43, respectively. However, when evaluating GenRA locally to clusters of structurally-similar chemicals (containing 2 to 362 chemicals), average R-2 values for systemic, developmental, reproductive, and cholinesterase LOAEL predictions improved to 0.73, 0.66, 0.60 and 0.79, respectively. Our findings highlight the complexity of the chemical-toxicity landscape and the importance of identifying local domains where GenRA can be used most effectively for predicting PODs.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Helman, G; Patlewicz, G; Shah, I or concate me.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article A 4-OTBS benzyl-based protective group for carboxylic acids published in 2019.0. Recommanded Product: 4-Nitrobenzoic acid, Reprint Addresses Xie, HX (corresponding author), East China Univ Sci & Technol, Sch Pharm, Shanghai Key Lab New Drug Design, State Key Lab Bioreactor Engn, Shanghai 200237, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Reported herein is a novel 4-OTBS benzyl-based protective group for carboxylic acids. This protective group can be removed in the presence of TBAF or TFA with high efficiency, which makes it compatible with base-sensitive or acid-sensitive substrates. With this protective group, a near-infrared fluorogenic probe for the detection of gamma-glutamyltranspeptidase activities was readily prepared. (C) 2019 Elsevier Ltd. All rights reserved.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Fang, ZJ; Li, YY; Xie, HX or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Battle tactics against MMP-9; discovery of novel non-hydroxamate MMP-9 inhibitors endowed with PI3K/AKT signaling attenuation and caspase 3/7 activation via Ugi bis-amide synthesis WOS:000509616800023 published article about MATRIX-METALLOPROTEINASE INHIBITORS; CANCER-CELL INVASION; BREAST-CANCER; MATRIX-METALLOPROTEINASE-9 ACTIVITY; CRYSTAL-STRUCTURES; TUMOR-GROWTH; DESIGN; ROLES; MULTICOMPONENT; OVEREXPRESSION in [Ayoup, Mohammed Salah; Fouad, Manar Ahmed; Abdel-Hamid, Hamida; Ramadan, El Sayed] Alexandria Univ, Fac Sci, Chem Dept, Alexandria 21321, Egypt; [Abu-Serie, Marwa M.] City Sci Res & Technol Applicat SRTA City, Genet Engn & Biotechnol Res Inst, Med Biotechnol Dept, Alexandria, Egypt; [Noby, Ahmed] Pharos Univ Alexandria, Fac Pharm, Dept Microbiol & Immunol, Alexandria 21311, Egypt; [Teleb, Mohamed] Alexandria Univ, Fac Pharm, Dept Pharmaceut Chem, Alexandria 21521, Egypt in 2020.0, Cited 84.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

Matrix metalloproteinases (MMPs) are major modulators of the tumor microenvironment. They participate in extracellular matrix turnover, tumor growth, angiogenesis and metastasis. Accordingly, MMPs inhibition seems to be ideal solution to control cancer. Many MMPs inhibitors have been introduced ranging from hydroxamate-based peptidomimetics to the next generation non-hydroxamate inhibitors. Among MMPs, MMP-9 is attractive druggable anticancer target. Studies showed that inhibiting AKT, the central signaling node of MMP-9 upregulation, provides additional MMP-9 blockade. Furthermore, caspase-dependent AKT cleavage leads to cell death. Herein, Ugi MCR was utilized as a rapid combinatorial approach to generate various decorated bis-amide scaffolds as dual MMP-9/AKT inhibitors endowed with caspase 3/7 activation potential. The target adducts were designed to mimic the thematic structural features of non-hydroxamate MMP inhibitors. p-Nitrophenyl isonitrile 1 was utilized as structure entry to Ugi products with some structural similarities to amide-based caspase 3/7 activators. Besides, various acids, amines and aldehydes were employed as Ugi educts to enrich the SAR data. All adducts were screened for cytotoxicity against normal fibroblasts and three cancer cell lines; MCF-7, NFS-60 and HepG-2 utilizing MTT assay. 8,11 and 28 were more active and safer than doxorubicin with single-digit nM IC50 and promising selectivity. Mechanistically, they exhibited dual MMP-9/AKT inhibition at single-digit nM IC50 with excellent selectivity over MMP-1,-2 and -13, and induced >51% caspase 3/7 activation. Consequently, they induced >49% apoptosis as detected by flow cytometric analysis, and inhibited cell migration (metastasis) up to 97% in cancer cells. Docking simulations were nearly consistent with enzymatic evaluation, also declared possible binding modes and essential structure features of active compounds. In silico physicochemical properties, ligand efficiency and drug-likeness metrics were reasonable for all adducts. Interestingly, 8 and 28 can be considered as drug-like candidates. (C) 2019 Elsevier Masson SAS. All rights reserved.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ayoup, MS; Fouad, MA; Abdel-Hamid, H; Ramadan, E; Abu-Serie, MM; Noby, A; Teleb, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis and anti-influenza A virus activity of novel 2,4-disubstituted quinazoline derivatives published in 2020. Computed Properties of C7H5NO4, Reprint Addresses Cen, S; Wang, YC (corresponding author), Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Four 2,4-disubstituted quinazoline series containing various amide moieties were designed and synthesized as new anti-influenza A virus agents using the strategies of bio-isosterism and scaffold hopping. Many of them exhibit potent in vitro anti-influenza A virus activity and low cytotoxicity (CC50: > 100 mu M). Particularly, compounds 10a5 and 17a show better activity (IC50: 3.70-4.19 mu M) and higher selective index (SI: > 27.03, > 23.87, respectively) against influenza A/WSN/33 virus (H1N1), opening a new direction for quinazoline derivatives in anti-influenza A virus field.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, MH; Zhang, GN; Wang, YJ; Wang, JX; Zhu, M; Cen, S; Wang, YC or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 4-Nitrobenzoic acid. Recently I am researching about CARBON-DIOXIDE; CYCLOHEXENE OXIDE; ALTERNATING COPOLYMERIZATION; CO2/EPOXIDE COPOLYMERIZATION; ASYMMETRIC COPOLYMERIZATION; TRIBLOCK COPOLYMERS; CYCLOPENTENE OXIDE; DIZINC CATALYST; MG-ZN; CO2, Saw an article supported by the EPSRCUK Research & Innovation (UKRI)Engineering & Physical Sciences Research Council (EPSRC) [EP/L017393/1, EP/K014668/1]; Climate KIC. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Trott, G; Garden, JA; Williams, CK. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The ring-opening copolymerization of carbon dioxide and epoxides is a useful means to make aliphatic polycarbonates and to add-value to CO2. Recently, the first heterodinuclear Zn(II)/Mg(II) catalyst showed greater activity than either homodinuclear analogue (J. Am. Chem. Soc. 2015, 137, 15078-15081). Building from this preliminary finding, here, eight new Zn(II)/Mg(II) heterodinuclear catalysts featuring carboxylate co-ligands are prepared and characterized. The best catalysts show very high activities for copolymerization using cyclohexene oxide (TOF 1/4 8880 h 1, 20 bar CO2, 120 C, 0.01 mol% catalyst loading) or cyclopentene oxide. All the catalysts are highly active in the low pressure regime and specifically at 1 bar pressure CO2. The polymerization kinetics are analysed using in situ spectroscopy and aliquot techniques: the rate law is overall second order with a first order dependence in both catalyst and epoxide concentrations and a zero order in carbon dioxide pressure. The pseudo first order rate coefficient values are compared for the catalyst series and differences are primarily attributed to effects on initiation rates. The data are consistent with a chain shuttling mechanistic hypothesis with heterodinuclear complexes showing particular rate enhancements by optimizing distinct roles in the catalytic cycles. The mechanistic hypothesis should underpin future heterodinuclear catalyst design for use both in other (co) polymerization and carbon dioxide utilization reactions.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Trott, G; Garden, JA; Williams, CK or concate me.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design and evaluation of Nrf2 activators with 1,3,4-oxa/thiadiazole core as neuro-protective agents against oxidative stress in PC-12 cells published in 2020.0, Reprint Addresses Sun, HP (corresponding author), China Pharmaceut Univ, Dept Med Chem, Nanjing 211198, Jiangsu, Peoples R China.; Feng, F (corresponding author), Jiangsu Food & Pharmaceut Sci Coll, Huaian 223003, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Oxidative stress plays vital roles in virous neurodegenerative diseases including Alzheimer’s disease. Activation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), the key regulator of oxidative stress, may provide a new therapeutic strategy for these diseases. Herein we synthesized and evaluated a series of 1,3,4-oxa/thiadiazole core Nrf2 activators as neuroprotective agents. The representative compound 8 exhibited cytoprotective and Nrf2 activation effects in a neuron-like PC-12 cells. Additionally, compound 8 showed good membrane permeability, indicating this compound could penetrate blood-brain barrier (BBB) to reach central nervous system (CNS) as a neuro-protective agent. These results indicated that these Nrf2 activators with 1,3,4-oxa/thiadiazole core could serve as a new chemotype against oxidative stress in neurodegenerative diseases.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Lin, HZ; Qiao, YT; Yang, HY; Li, Q; Chen, Y; Qu, W; Liu, WY; Feng, F; Sun, HP or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CONTINUOUS-FLOW SYNTHESIS; O-QUINODIMETHANES; ALDEHYDES; BENZYLATION; REDUCTION; CHEMISTRY; EFFICIENT; CATALYST, Saw an article supported by the Department of Science and Technology, New Delhi (Govt. of India) (DST)Department of Science & Technology (India); CSIRCouncil of Scientific & Industrial Research (CSIR) – India [MLP-32]; DSTDepartment of Science & Technology (India); Science and Engineering Research Board (SERB) [DST/INSPIRE/04/2016/000247, ECR/2017/000208]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Aand, D; Mahajan, B; Pabbaraja, S; Singh, AK. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Name: 4-Nitrobenzoic acid

Direct utilization of the abundant hydrogen in water for the transfer hydrogenation reaction (THR) is a very attractive and challenging research area. Herein, we report the first integrated photo-transfer hydrogenation reaction (PTHR) platform for the synthesis of benzhydrol derivatives (26 examples, 33-89% yields) with water as a green reducing agent. This transformation is time and labor-efficient, catalyst-free, and economical and utilizes readily available hydrocarbon(s) (o-methyl phenyl ketones) as starting materials.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Aand, D; Mahajan, B; Pabbaraja, S; Singh, AK or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. In 2019.0 ORG LETT published article about TRACELESS DIRECTING GROUPS; CARBOXYLIC-ACIDS; ENANTIOSELECTIVE SYNTHESIS; COUPLING REACTIONS; ORTHO-ARYLATION; BENZOIC-ACIDS; IODINE; ACTIVATION; BIARYLS; ALKYNES in [Hu, Tao; Xu, Kai; Ye, Zenghui; Zhu, Kai; Zhang, Fengzhi] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China; [Wu, Yanqi] Zhejiang Univ Technol, Inst Informat Resource, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 63.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

We report here a two-in-one strategy for the Pd(II)-catalyzed tandem C-H arylation/decarboxylative annulation between readily available cyclic diaryliodonium salts and benzoic acids. The carboxylic acid functionality can be used as both a directing group for the ortho-C-H arylation and the reactive group for the tandem decarboxylative annulation. By a step-economical double cross-coupling annulation procedure, the privileged triphenylene frameworks were efficiently constructed, which have potential applications in material chemistry.

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hu, T; Xu, K; Ye, ZH; Zhu, K; Wu, YQ; Zhang, FZ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem