Month: October 2021

An article Synthesis of Dithiolethiones and Identification of Potential Neuroprotective Agents via Activation of Nrf2-Driven Antioxidant Enzymes WOS:000515216200046 published article about CUL3-BASED E3 LIGASE; OXIDATIVE STRESS; THERAPEUTIC TARGET; PC12 CELLS; NEURODEGENERATIVE DISEASES; MITOCHONDRIAL DYSFUNCTION; KEAP1-NRF2-ARE PATHWAY; BIOLOGICAL EVALUATION; HYDROGEN-PEROXIDE; CANCER PREVENTION in [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, State Key Lab Appl Organ Chem, Lanzhou 730000, Peoples R China; [Song, Zi-Long; Bai, Feifei; Zhang, Baoxin; Fang, Jianguo] Lanzhou Univ, Coll Chem & Chem Engn, Lanzhou 730000, Peoples R China in 2020, Cited 70. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

Oxidative stress is implicated in the pathogenesis of a wide variety of neurodegenerative disorders, and accordingly, dietary supplement of exogenous antioxidants or/and upregulation of the endogenous antioxidant defense system are promising for therapeutic intervention or chemoprevention of neurodegenerative diseases. Nrf2, a master regulator of the cellular antioxidant machinery, cardinally participates in the transcription of cytoprotective genes against oxidative/electrophilic stresses. Herein, we report the synthesis of 59 structurally diverse dithiolethiones and evaluation of their neuroprotection against 6-hydroxydopamine- or H2O2 -induced oxidative damages in PC12 cells, a neuron-like rat pheochromocytoma cell line. Initial screening identified compounds 10 and 11 having low cytotoxicity but conferring remarkable protection on PC12 cells from oxidative-mediated damages. Further studies demonstrated that both compounds upregulated a battery of antioxidant genes as well as corresponding genes’ products. Significantly, silence of Nrf2 expression abolishes cytoprotection of 10 and 11, indicating targeting Nrf2 activation is pivotal for their cellular functions. Taken together, the two lead compounds discovered here with potent neuroprotective functions against oxidative stress via Nrf2 activation merit further development as therapeutic or chemopreventive candidates for neurodegenerative disorders.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Song, ZL; Bai, FF; Zhang, BX; Fang, JG or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Gao, EJ; Wu, SY; Wang, J; Zhu, MC; Zhang, Y; Fedin, VP in [Gao, Enjun] Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan 114051, Liaoning, Peoples R China; [Gao, Enjun; Wu, Shuangyan; Wang, Jing; Zhu, Mingchang; Zhang, Ying] Shenyang Univ Chem Technol, Key Lab Inorgan Mol Based Chem Liaoning Prov, 11th St, Shenyang 110142, Liaoning, Peoples R China; [Gao, Enjun; Wu, Shuangyan; Wang, Jing; Zhu, Mingchang; Zhang, Ying] Shenyang Univ Chem Technol, Lab Coordinat Chem, 11th St, Shenyang 110142, Liaoning, Peoples R China; [Fedin, Vladimir P.] Nikolaev Inst Inorgan Chem, Lavrentiev Ave 3, Novosibirsk 630090, Russia published Water-Stable Lanthanide Coordination Polymers with Triple Luminescent Centers for Tunable Emission and Efficient Self-Calibration Sensing Wastewater Pollutants in 2020.0, Cited 86.0. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Conventional luminescent sensors relying on single emission responsive to analytes demonstrate limited sensitivity and selectivity and developing novel self-calibration probes is highly required. A series of water-stable coordination polymers (CPs) with three emitting centers for tunable emissions is reported. They are facilely synthesized by simultaneously doping red-emitting Eu3+ and green-emitting Tb3+ into the same framework. The versatile Eu0.67Tb0.33-CP is applied to conveniently distinguishing different nitroaromatics pollutants and multidimensional ratiometric sensing CrO42-/Cr2O72-. Specific nitroaromatics can cause unique changes to the ligand -> Eu3+/Tb3+ energy transfer efficiency, while CrO42-/Cr2O72- intriguingly quench the three emissions at different rates. Each nitroaromatic exhibits notably correlation to a unique combination of the two ligand -> Eu3+/Tb3+ emission intensity ratios, enabling a 2D fingerprint recognition. Furthermore, the concentration-dependent evolution of the two ratios upon exposure to CrO42-/Cr2O72- can be mapped out, achieving a 3D code recognition. As a result, the sensor demonstrates selective recognition of 4-nitrophenol and CrO42-/Cr2O72- with high sensitivity and selectivity as well as great recycling ability. Both the synthetic and sensing strategies present a promising strategy to develop facile and effective ratiometric sensors.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Gao, EJ; Wu, SY; Wang, J; Zhu, MC; Zhang, Y; Fedin, VP or concate me.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Copper nitrate-mediated synthesis of 3-aryl isoxazolines and isoxazoles from olefinic azlactones WOS:000482917600008 published article about AMINO-ACIDS; 1,3-DIPOLAR CYCLOADDITION; SELECTIVE INHIBITOR; DIRECT CONVERSION; NITRILE OXIDES; ALKENES; ALKYNES; POTENT; DIPOLAROPHILES; CONSTRUCTION in [Lin, Yifan; Zhang, Ke; Gao, Mingchun; Jiang, Zheyi; Liu, Jiajie; Ma, Yurui; Wang, Haoyu; Tan, Qitao; Xiao, Junjie; Xu, Bin] Shanghai Univ, Qianweichang Coll, Sch Life Sci, Innovat Drug Res Ctr,Dept Chem, Shanghai 200444, Peoples R China; [Xu, Bin] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China in 2019.0, Cited 61.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A copper nitrate-mediated [2 + 2 + 1] cycloaddition reaction was developed for the expedient synthesis of pharmacologically interesting 3-aryl substituted isoxazolines and isoxazoles through C = C bond cleavage. Copper nitrate is employed as a reaction promoter and precursor of nitrile oxides. The given approach features a new mode of cycloaddition from olefinic azlactones, copper nitrate and unsaturated compounds with wide substrate scope, good functional group tolerance and operational simplicity.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Lin, YF; Zhang, K; Gao, MC; Jiang, ZY; Liu, JJ; Ma, YR; Wang, HY; Tan, QT; Xiao, JJ; Xu, B or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Design, Synthesis, and Biological Evaluation of (E)-N’-((1-Chloro-3,4-Dihydronaphthalen-2-yl)Methylene)Benzohydrazide Derivatives as Anti-prostate Cancer Agents WOS:000474717400001 published article about ANDROGEN RECEPTOR ANTAGONISTS; HYDRAZIDE-HYDRAZONES; ANTIANDROGEN; DYNAMICS; ARN-509 in [Arjun, H. A.; Elancheran, Ramakrishnan; Lakshmithendral, K.; Kabilan, Senthamaraikannan] Annamalai Univ, Dept Chem, Drug Discovery Lab, Chidambaram, India; [Manikandan, N.; Ramanathan, Muthiah] PSG Coll Pharm, Dept Pharmacol, Coimbatore, Tamil Nadu, India; [Bhattacharjee, Atanu] North Eastern Hill Univ, Dept Biotechnol & Bioinformat, Computat Biol Lab, Shillong, Meghalaya, India; [Lokanath, N. K.] Univ Mysore, Dept Phys, Mysore, Karnataka, India in 2019, Cited 53. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

Prostate Cancer (PCa) is the most frequently diagnosed cancer in men in their late ’50s. PCa growth is mainly due to the activation of the androgen receptor by androgens. The treatment for PCa may involve surgery, hormonal therapy, and oral chemotherapeutic drugs. A structural based molecular docking approach revealed the findings of (E)-N’-((1-chloro-3,4-dihydronaphthalen-2-yl)methylene)benzohydrazide derivatives, where the possible binding modes of the compounds with protein (PDB ID: 3V49) are shown. The compounds (6a-k) were synthesized and characterized by using conventional methods. The compounds, 6g, 6j, and 6k were reconfirmed through single crystal X-ray diffraction (XRD). Further, the compounds (6a-k) and standard drug were evaluated against human prostate cancer cell lines, LNCaP and PC-3 and the non-cancerous cell line, 3T3. Among these compounds, 6g and 6j showed higher cytotoxicity, and 6g exhibited dose-dependent activity and reduced cell viability. The mechanism of action was observed through the induced apoptosis and was further confirmed by western blot and ELISA. Molecular dynamics simulation studies were carried out to calculate the interaction and the stability of the protein-ligand complex in motion. ADME properties were predicted for all the tested compounds. These findings may give vital information for further development.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Arjun, HA; Elancheran, R; Manikandan, N; Lakshmithendral, K; Ramanathan, M; Bhattacharjee, A; Lokanath, NK; Kabilan, S or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about IN-VITRO; ANTITUMOR-ACTIVITY; BETULINIC ACID; APOPTOSIS; CANCER, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81673306]; Double First-Class University project, China Pharmaceutical University [CPU2018GY04, CPU2018GY35]. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Lu, LX; Zhang, HY; Liu, J; Liu, Y; Wang, YW; Xu, ST; Zhu, ZY; Xu, JY. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Product Details of 62-23-7

A series of C-23 modified 23-hydroxybetulinic acid (HBA) derivatives were synthesized and evaluated for their antiproliferative activity against a panel of cancer cell lines (A2780, A375, B16, MCF-7 and HepG2). The biological screening results showed that most of the derivatives exhibited more potent antiproliferative activity than HBA, and compound 6e exhibited the most potent activity with IC50 values of 2.14 mu M, 2.89 mu M, and 3.97 mu M against A2780, B16, and MCF-7 cells, respectively. Further anticancer mechanism studies revealed that compound 6e induced the generation of intracellular reactive oxygen species (ROS) and reduction of mitochondrial membrane potential (MMP) of B16 cells in a dose-dependent manner. Moreover, western blot analysis indicated that compound 6e downregulated the expression of anti-apoptotic protein Bcl-2 and upregulated the expression of proapoptotic protein Bax, activation of caspase 3 to induce cell apoptosis. Meanwhile, compound 6e significantly inhibited the phosphorylation of MEK, ERK, and Akt without affecting the expression of MEK, ERK, and Akt. Furthermore, the in vivo anti-tumor activity of 6e was validated (tumor inhibitory ratio of 68.4% at the dose of 30 mg/kg) in mice with B16 melanoma. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Lu, LX; Zhang, HY; Liu, J; Liu, Y; Wang, YW; Xu, ST; Zhu, ZY; Xu, JY or concate me.. Product Details of 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Quality Control of 4-Nitrobenzoic acid. I found the field of Chemistry; Engineering very interesting. Saw the article Integrated continuous flow/batch protocol for the photoreduction of ortho-methyl phenyl ketones using water as the hydrogen source published in 2019, Reprint Addresses Pabbaraja, S; Singh, AK (corresponding author), Indian Inst Chem Technol, CSIR, Dept Organ Synth & Proc Chem, Hyderabad, India.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Direct utilization of the abundant hydrogen in water for the transfer hydrogenation reaction (THR) is a very attractive and challenging research area. Herein, we report the first integrated photo-transfer hydrogenation reaction (PTHR) platform for the synthesis of benzhydrol derivatives (26 examples, 33-89% yields) with water as a green reducing agent. This transformation is time and labor-efficient, catalyst-free, and economical and utilizes readily available hydrocarbon(s) (o-methyl phenyl ketones) as starting materials.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Aand, D; Mahajan, B; Pabbaraja, S; Singh, AK or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Ni-catalyzed direct alcoholysis of N-acylpyrrole-type tertiary amides under mild conditions published in 2020.0. Recommanded Product: 62-23-7, Reprint Addresses Huang, PQ (corresponding author), Xiamen Univ, Coll Chem & Chem Engn, Collaborat Innovat Ctr Chem Ene Mat, Dept Chem,Fujian Prov Key Lab Chem Biol, Xiamen 361005, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

N-Acylpyrrole-type amides are a class of versatile building blocks in asymmetric synthesis. We report that by employing Ni(COD)(2)/2,2 ‘-bipyridine (5 mol%) catalytic system, the direct, catalytic alcoholysis of N-acylpyrrole-type aromatic and aliphatic amides with both primary and secondary alcohols can be achieved efficiently under very mild conditions (rt, 1 h) even at gram scale. By increasing the catalyst loading to 10 mol%, prolonging reaction time (18 h), and/or elevating reaction temperature to 50 degrees C/80 degrees C, the reaction could be extended to both complex and hindered N-acylpyrroles as well as to N-acylpyrazoles, Nacylindoles, and to other (functionalized) primary and secondary alcohols. In all cases, only 1.5 equiv. of alcohol were used. The value of the method has been demonstrated by the racemization-free, catalytic alcoholysis of chiral amides yielded from other asymmetric methodologies.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Chen, H; Chen, DH; Huang, PQ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Total syntheses of several iridolactones and the putative structure of noriridoid scholarein A: an intramolecular Pauson-Khand reaction based one-stop synthetic solution WOS:000476549400014 published article about NATURALLY-OCCURRING IRIDOIDS; ENANTIOSELECTIVE TOTAL-SYNTHESIS; SOLVOMERCURATION-DEMERCURATION; ISOIRIDOMYRMECIN; STEREOCHEMISTRY; IRIDOMYRMECIN; SECOIRIDOIDS; OXIDATION; ACID in [Salam, Abdus; Ray, Sayan; Abu Zaid, Md; Kumar, Dileep; Khan, Tabrez] Indian Inst Technol Bhubaneswar, Sch Basic Sci, Organ Synth Lab, Khurdha 752050, Odisha, India in 2019.0, Cited 55.0. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A simple and general approach towards the total syntheses of several iridolactones such as (+/-)-boschnialactone, (+/-)-7-epi-boschnialactone, (+/-)-teucriumlactone, (+/-)-iridomyrmecin, (+/-)-isoboonein, (+/-)-7-epi-argyol, (+/-)-scabrol A, (+/-)-7-epi-scabrol A, and (+/-)-patriscabrol as well as the putative structure of scholarein A is delineated. The synthetic strategy features a diastereoselective intramolecular Pauson-Khand reaction (IPKR) to construct the iridoid framework followed by some strategic synthetic manipulations to access the targeted monoterpenes including those having diverse oxy-functionalization patterns and with 3-5 contiguous stereogenic centres in a highly stereocontrolled manner. Also, the present endeavour includes the first total synthesis of scabrol A.

SDS of cas: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Salam, A; Ray, S; Abu Zaid, M; Kumar, D; Khan, T or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Chiral terpene auxiliaries V: Synthesis of new chiral gamma-hydroxyphosphine oxides derived from alpha-pinene published in 2019.0. HPLC of Formula: C7H5NO4, Reprint Addresses Krzeminski, MP (corresponding author), Nicolaus Copernicus Univ Torun, Fac Chem, 7 Gagarin St, PL-87100 Torun, Poland.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

New chiral regioisomeric gamma-hydroxyphosphine ligands were synthesized from alpha-pinene. The key transformation was the thermal [2,3]-sigmatropic rearrangement of allyldiphenylphosphinites, obtained from (1R,2R,4S,5R)-3-methyleneneoisoverbanol and (1R,2R,3R,5R)-4-methyleneneoisopinocampheol, to allylphosphine oxides. Hydroxy groups were introduced stereoselectively through a hydroboration-oxidation reaction proceeding from the less hindered site providing a trans relationship between the hydroxy and the phosphine substituents.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Kmieciak, A; Krzeminski, MP or concate me.. HPLC of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about PASSERINI REACTION; MULTICOMPONENT REACTIONS; MEDIA; GREEN, Saw an article supported by the Research Council of Tarbiat Modares University. Application In Synthesis of 4-Nitrobenzoic acid. Published in SPRINGER WIEN in WIEN ,Authors: Yavari, I; Khajeh-Khezri, A; Ghorbanzadeh, M; Halvagar, MR. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The Passerini three-component reaction between acenaphthylene-1,2-dione, alkyl isocyanides, and carboxylic acids, leading to the formation of alpha-acyloxyamides in common organic solvents (CH2Cl2, MeOH) and choline chloride-based deep eutectic solvent, is described. The reaction in the latter solvent proceeded faster compared to common organic solvents. The structure of a typical product was confirmed by X-ray crystallography. [GRAPHICS] .

Application In Synthesis of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Yavari, I; Khajeh-Khezri, A; Ghorbanzadeh, M; Halvagar, MR or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem