Month: October 2021

Application In Synthesis of 4-Nitrobenzoic acid. Recently I am researching about MYCOBACTERIUM-TUBERCULOSIS; CLINICAL CANDIDATE; DERIVATIVES; DISCOVERY; PYRIDINE; Q203, Saw an article supported by the Department of Science and Technology, Government of IndiaDepartment of Science & Technology (India) [GAP0584]; Council of Scientific and Industrial Research (CSIR)Council of Scientific & Industrial Research (CSIR) – India; UGC, Government of IndiaUniversity Grants Commission, India. Published in FUTURE SCI LTD in LONDON ,Authors: Makane, VB; Krishna, VS; Krishna, EV; Shukla, M; Mahizhaveni, B; Misra, S; Chopra, S; Sriram, D; Dusthackeer, VNA; Rode, HB. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Aim: In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis. Here, we are disclosing the 5-substitued 2-mercapto-1,3,4-oxadiazoles as potent antitubercular agents. Methodology: A small library of 2-mercapto-1,3,4-oxadiazoles was synthesized using various acids. The compounds were evaluated for antituberculosis activity against M. tuberculosis H37Rv. Results: Compound 8j was identified as antitubercular lead with MIC of 0.6g/ml against M. tuberculosis H37Rv. This compound was nontoxic to CHO-K1 cells and showed selectivity index of 39. Of note, 8j showed antitubercular activity against pre-extensively drug-resistant clinical isolate of Mycobacterium with MIC of 2g/ml. Conclusion: This study provides potent antitubercular agent which can be further optimized to discover novel antibiotics. [GRAPHICS] .

Application In Synthesis of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Makane, VB; Krishna, VS; Krishna, EV; Shukla, M; Mahizhaveni, B; Misra, S; Chopra, S; Sriram, D; Dusthackeer, VNA; Rode, HB or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ASIAN J ORG CHEM published article about CATALYTIC ENANTIOSELECTIVE CONSTRUCTION; UNPRECEDENTED STEREOCHEMICAL CONTROL; PRACTICAL ASYMMETRIC-SYNTHESIS; ALLYLIC ALKYLATION; NATURAL-PRODUCTS; ORGANOALUMINUM REAGENTS; CLAISEN REARRANGEMENT; STEREOGENIC CENTERS; SILYL ETHERS; THREO ALDOLS in [Hirama, Naomichi; Sakamoto, Ryu; Maruoka, Keiji] Kyoto Univ, Grad Sch Sci, Dept Chem, Sakyo Ku, Kyoto 6068502, Japan; [Maruoka, Keiji] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou, Guangdong, Peoples R China in 2019.0, Cited 71.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

This article describes a Lewis-acid-promoted semi-pinacol rearrangement of chiral epoxy alcohols to provide chiral beta-hydroxy aldehydes with a quaternary center at the alpha-position that are otherwise difficult to access in modern organic synthesis. The aldehydes thus obtained are highly useful synthetic intermediates, which is demonstrated by the synthesis of a serotonin antagonist.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hirama, N; Sakamoto, R; Maruoka, K or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. Recently I am researching about HYDROPHILIC INTERACTION CHROMATOGRAPHY; SILICA; ANION; SEPARATION; POLAR, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21277110]. Published in ELSEVIER in AMSTERDAM ,Authors: Wang, X; Peng, JD; Peng, HJ; Chen, J; Xian, H; Ni, RX; Li, SY; Long, DY; Zhang, ZY. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

The present work describes the preparation of two ionic liquid and carboxyl acid silane reagents via photo-initiated thiol-ene click chemistry that have been bonded to silica to afford two mixed-mode stationary phases (Sil-C4Im-C9Co and Sil-C9Im-C4Co). The two stationary phases provided satisfactory retention repeatability and efficiencies. The influence of acetonitrile content, salt concentration and pH of the mobile phase was investigated to clarify the retention properties of the prepared stationary phases. The results showed that the prepared Sil-C4Im-C9Co and Sil-C9Im-C4Co undergo multiple interactions with solutes under different chromatographic conditions. The retention mechanisms were further studied by the linear energy solvation relationship and Van’t Hoff plots. Finally, the stationary phases were employed to separate hydrophobic solutes (alkylbenzenes and polycyclic aromatic hydrocarbons) under reversed phase liquid chromatography (RPLC) mode, hydrophilic solutes (carboxylic acids, nucleosides and bases) under hydrophilic interaction liquid chromatography (HILIC) mode and inorganic anions under ion-exchange chromatography (IEC) mode, providing excellent performance and varying selectivity when compared with a commercial column. The bonding method in this work is feasible and the prepared stationary phases are promising when employed in RPLC/HILIC/IEC mixed-mode chromatography applications. (C) 2019 Elsevier B.V. All rights reserved.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Wang, X; Peng, JD; Peng, HJ; Chen, J; Xian, H; Ni, RX; Li, SY; Long, DY; Zhang, ZY or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Two-in-One Strategy for the Pd(II)-Catalyzed Tandem C-H Arylation/Decarboxylative Annulation Involved with Cyclic Diaryliodonium Salts WOS:000487577200010 published article about TRACELESS DIRECTING GROUPS; CARBOXYLIC-ACIDS; ENANTIOSELECTIVE SYNTHESIS; COUPLING REACTIONS; ORTHO-ARYLATION; BENZOIC-ACIDS; IODINE; ACTIVATION; BIARYLS; ALKYNES in [Hu, Tao; Xu, Kai; Ye, Zenghui; Zhu, Kai; Zhang, Fengzhi] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China; [Wu, Yanqi] Zhejiang Univ Technol, Inst Informat Resource, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 63.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We report here a two-in-one strategy for the Pd(II)-catalyzed tandem C-H arylation/decarboxylative annulation between readily available cyclic diaryliodonium salts and benzoic acids. The carboxylic acid functionality can be used as both a directing group for the ortho-C-H arylation and the reactive group for the tandem decarboxylative annulation. By a step-economical double cross-coupling annulation procedure, the privileged triphenylene frameworks were efficiently constructed, which have potential applications in material chemistry.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Hu, T; Xu, K; Ye, ZH; Zhu, K; Wu, YQ; Zhang, FZ or concate me.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Shen, SQ; Dong, LL; Lu, HZ; Dong, YH; Yang, Q; Zhang, JJ in [Shen, Shengqiang; Dong, Lili; Lu, Huizhe; Dong, Yanhong; Zhang, Jianjun] China Agr Univ, Coll Sci, Dept Pesticide Chem, Beijing, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, State Key Lab Biol Plant Dis & Insect Pests, Inst Plant Protect, Beijing, Peoples R China; [Yang, Qing] Chinese Acad Agr Sci, Shenzhen Agr Genome Res Inst, Beijing, Peoples R China published Synthesis of ureido thioglycosides as novel insect beta-N-acetylhexosaminidase OfHex1 inhibitors in 2020.0, Cited 24.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The insect beta-N-acetylhexosaminidase OfHex1 from Ostrinia furnacalis (one of the most destructive agricultural pests) has been considered as a promising pesticide target. In this study, a series of novel and readily available ureido thioglycosides were designed and synthesized based on the catalytic mechanism and the co-crystal structures of OfHex1 with substrates. After evaluation via enzyme inhibition experiments, thioglycosides 11c and 15k were found to have inhibitory activities against OfHex1 with the K-i values of 25.6 mu M and 53.8 mu M, respectively. In addition, all these ureido thioglycosides exhibited high selectivity toward OfHex1 over hOGA and HsHexB (K-i > 100 mu M). Furthermore, to investigate the inhibitory mechanism, the possible binding modes of 11c and 15k with OfHex1 were deduced based on molecular docking analysis. This work may provide useful structural starting points for further rational design of potent inhibitors of OfHex1.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Shen, SQ; Dong, LL; Lu, HZ; Dong, YH; Yang, Q; Zhang, JJ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Organocatalytic asymmetric Michael addition between 3-subsituted oxindoles and enals catalyzed by camphor sulfonyl hydrazine published in 2019.0. HPLC of Formula: C7H5NO4, Reprint Addresses Chen, LY; Li, Y (corresponding author), Shanghai Univ Engn Sci, Coll Chem & Chem Engn, 333 Longteng Rd, Shanghai 201620, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Organocatalytic asymmetric Michael addition between 3-substituted oxindoles and enals catalyzed by chiral camphor sulfonyl hydrazines (CaSHs) has been developed. A wide range of 3-substituted oxindoles and enals were successfully used, giving the corresponding 3,3-disubstituted oxindoles containing vicinal stereogenic carbon centers in good yields with good to excellent enantioselectivities and moderate to good diastereoselectivities (up to 89% yield, 99% ee and 99 : 1 dr).

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Cheng, WF; Chen, LY; Xu, FF; Lin, WY; Ren, XR; Li, Y or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about COPPER-CATALYZED CARBOXYLATION; LATE-STAGE FUNCTIONALIZATION; BOND FUNCTIONALIZATION; 1,3-DISUBSTITUTED ARENES; ESTERS; ACTIVATION; REGIOSELECTIVITY; DIVERSIFICATION; CONSTRUCTION; HETEROARENES, Saw an article supported by the NordForsk [85378]; Tromso Research Foundation [TFS2016KHH]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Gevorgyan, A; Hopmann, KH; Bayer, A. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Recommanded Product: 62-23-7

A formal C-H carboxylation of unactivated arenes using CO2 in green solvents is described. The present strategy combines a sterically controlled Ir-catalyzed C-H borylation followed by a Cu-catalyzed carboxylation of the in situ generated organoboronates. The reaction is highly regioselective for the C-H carboxylation of 1,3-disubstituted and 1,2,3-trisubstituted benzenes, 1,2- or 1,4-symmetrically substituted benzenes, fluorinated benzenes and different heterocycles. The developed methodology was applied to the late-stage C-H carboxylation of commercial drugs and ligands.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Gevorgyan, A; Hopmann, KH; Bayer, A or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. Morris, J; Kozlowski, P; Wang, GJ in [Morris, Joedian; Kozlowski, Paige; Wang, Guijun] Old Dominion Univ, Dept Chem & Biochem, Norfolk, VA 23529 USA published Synthesis and Characterization of Hybrid Glycolipids as Functional Organogelators and Hydrogelators in 2019.0, Cited 46.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Carbohydrate-based low-molecular-weight gelators are useful and versatile compounds for the preparation of soft materials. Using N-acetyl-D-glucosamine as the starting material, we synthesized and characterized 15 glycolipids containing an amide with different ester functional groups. These include aliphatic derivatives with varying chain lengths and aromatic derivatives. Most of the hybrid amide-esters have molecular weights less than 500 D. These glycolipids were found to be effective gelators for several organic solvents, water, and aqueous solutions. Two efficient hydrogelators were also obtained at low concentrations. A few representative gels were characterized using optical microscopy, atomic force microscopy, and rheology to obtain information on their morphology and gel stability. Three gelators were also used to encapsulate naproxen sodium and toluidine blue. The sustained release of the drug from the gel to the aqueous phase was monitored by UV-vis spectroscopy. These gelators have structural flexibility that can be stimuli responsive. The esters can be hydrolyzed and several gels were converted to solutions under basic conditions. These rationally designed gelators could be utilized as stimuli-responsive smart materials with controlled release properties.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Morris, J; Kozlowski, P; Wang, GJ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. In 2020.0 ACS MED CHEM LETT published article about HISTONE DEACETYLASE INHIBITOR; ACCURATE DOCKING; IN-VITRO; GLIDE; RICOLINOSTAT; MODEL; CELL in [Shouksmith, Andrew E.; Gawel, Justyna M.; Nawar, Nabanita; Sina, Diana; Raouf, Yasir S.; Bukhari, Shazreh; He, Liying; Johns, Alexandra E.; Manaswiyoungkul, Pimyupa; Olaoye, Olasunkanmi O.; Cabral, Aaron D.; Sedighi, Abootaleb; de Araujo, Elvin D.; Gunning, Patrick T.] Univ Toronto Mississauga, Dept Chem & Phys Sci, 3359 Mississauga Rd, Mississauga, ON L5L 1C6, Canada in 2020.0, Cited 25.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The HDAC inhibitor 4-tert-butyl-N-(4-(hydroxycarbamoyl)phenyl)benzamide (AES-350, 51) was identified as a promising preclinical candidate for the treatment of acute myeloid leukemia (AML), an aggressive malignancy with a meagre 24% 5-year survival rate. Through screening of low-molecular-weight analogues derived from the previously discovered novel HDAC inhibitor, AES-135, compound 51 demonstrated greater HDAC isoform selectivity, higher cytotoxicity in MV4-11 cells, an improved therapeutic window, and more efficient absorption through cellular and lipid membranes. Compound 51 also demonstrated improved oral bioavailability compared to SAHA in mouse models. A broad spectrum of experiments, including FACS, ELISA, and Western blotting, were performed to support our hypothesis that 51 dose-dependently triggers apoptosis in AML cells through HDAC inhibition.

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Shouksmith, AE; Gawel, JM; Nawar, N; Sina, D; Raouf, YS; Bukhari, S; He, LY; Johns, AE; Manaswiyoungkul, P; Olaoye, OO; Cabral, AD; Sedighi, A; de Araujo, ED; Gunning, PT or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 TETRAHEDRON LETT published article about DISCOVERY; EFFICIENT in [Chen, Ling; Luo, Guanglin] Bristol Myers Squibb Res & Dev, POB 4000, Princeton, NJ 08543 USA in 2019, Cited 15. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. SDS of cas: 62-23-7

A fast and convenient method using the Mukaiyama reagent was developed to prepare acyl sulfonamides from carboxylic acids and sulfonamides. This methodology is effective for a range of acids and sulfonamides proceeding in moderate to good yields with the majority of reactions complete within one hour under the optimized condition. (C) 2018 Elsevier Ltd. All rights reserved.

SDS of cas: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Chen, L; Luo, GL or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem