Month: October 2021

An article Asymmetric Michael Addition of Unactivated Ketones with beta-Nitrostyrenes Mediated by Bifunctional L-Prolinamide Organocatalysts WOS:000516865300011 published article about ENANTIOSELECTIVE CONJUGATE ADDITION; CARBONYL-COMPOUNDS; NITROOLEFINS; CATALYSIS; CYCLOHEXANONE; NITROALKANES; CONSTRUCTION; DERIVATIVES; ACID; 3-HYDROXY-2-OXINDOLES in [Rani, Dixita; Bhargava, Meha; Agarwal, Jyoti] Panjab Univ, Dept Chem, Chandigarh 160014, India; [Rani, Dixita; Bhargava, Meha; Agarwal, Jyoti] Panjab Univ, Ctr Adv Studies, Chandigarh 160014, India in 2020.0, Cited 102.0. Product Details of 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The catalytic activity of two types of L-prolinamide organocatalysts was investigated for asymmetric Michael addition reaction of cyclic/acyclic ketones with beta-nitrostyrens. L-Prolinamides bearing amino groups on phenyl ring worked well, though their catalytic efficiency as well as selectivity was found to be dependent upon the position of amine group to the amide bond. Organocatalyst having -NH2 group ortho to amide bond provided the best results. Substrate scope was also studied by performing the reaction of various beta-nitrostyrenes with ketones to afford the corresponding Michael adducts in excellent yields with very high diastereoselectivities and enantioselectivities in almost all cases.

Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Rani, D; Bhargava, M; Agarwal, J or concate me.

Reference:
Phthalazine – Wikipedia,
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An article Palladium supported on a novel ordered mesoporous polypyrrole/carbon nanocomposite as a powerful heterogeneous catalyst for the aerobic oxidation of alcohols to carboxylic acids and ketones on water WOS:000530352000033 published article about HIGHLY SELECTIVE OXIDATION; PLATINUM CATALYST; MOLECULAR-OXYGEN; ALLYLIC ALCOHOLS; PORE STRUCTURE; POROUS CARBON; ALDEHYDES; EFFICIENT; NANOPARTICLES; SURFACE in [Ganji, Nasim; Karimi, Babak; Najafvand-Derikvandi, Sepideh] Inst Adv Studies Basic Sci IASBS, Dept Chem, POB 45195-1159, Gava Zang 451376731, Zanjan, Iran; [Karimi, Babak] Inst Adv Studies Basic Sci IASBS, Res Ctr Basic Sci & Modern Technol RBST, Zanjan 4513766731, Iran; [Vali, Hojatollah] McGill Univ, Dept Anat & Cell Biol, Montreal, PQ H3A 2A7, Canada; [Vali, Hojatollah] McGill Univ, Facil Electron Microscopy Res, Montreal, PQ H3A 2A7, Canada in 2020, Cited 86. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

Preparation of an ordered mesoporous polypyrrole/carbon (PPy/OMC) composite has been described through a two-step nanocasting process using KIT-6 as a template. Characterization of the PPy/OMC nanocomposite by various analysis methods such as TEM, XRD, TGA, SEM and N-2 sorption confirmed the preparation of a material with ordered mesoporous structure, uniform pore size distribution, high surface area and high stability. This nanocomposite was then used for the immobilization of palladium nanoparticles. The nanoparticles were almost uniformly distributed on the support with a narrow particle size of 20-25 nm, confirmed by various analysis methods. Performance of the Pd@PPy/OMC catalyst was evaluated in the aerobic oxidation of various primary and secondary alcohols on water as a green solvent, giving the corresponding carboxylic acids and ketones in high yields and excellent selectivity. The catalyst could also be reused for at least 10 reaction runs without losing its catalytic activity and selectivity. High catalytic efficiency of the catalyst can be attributed to a strong synergism between the PPy/OMC and that of supported Pd nanoparticles.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ganji, N; Karimi, B; Najafvand-Derikvandi, S; Vali, H or concate me.

Reference:
Phthalazine – Wikipedia,
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Recently I am researching about NATURAL-PRODUCT SYNTHESIS; ELECTROCATALYTIC APPROACH; MULTICOMPONENT REACTIONS; N-ACYL; AMIDES; AMINES; ISOIMIDES; OXIDATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21672104, 21502097]; Priority Academic Program Development of Jiangsu Higher Education Institutions. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Zhang, XF; Cui, T; Zhao, X; Liu, P; Sun, PP. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Recommanded Product: 62-23-7

An electrochemical four-component reaction cascade Mumm rearrangement was developed. It is a rare example of in situ generation of O-acyl isoamides for 1,3-(O -> N) acyl transfer. Inexpensive, commercially available arylethylenes, aryl or heterocyclic acids, acetonitrile, and alcohols were used as substrates. A wide range of aryl acids and alcohols were tolerated and provided imides in satisfactory yields. Subsequent hydrolysis of imides could be utilized to synthesize valuable amides and beta-amino alcohol derivatives.

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Reference:
Phthalazine – Wikipedia,
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Name: 4-Nitrobenzoic acid. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles published in 2019.0, Reprint Addresses Couri, MRC (corresponding author), Univ Fed Juiz de Fora, Dept Quim, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A series of1,2,4- and 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Halogenated 1,2,4-oxadiazoles were obtained from benzonitrile and coupled either lipophilic amines or with aminoalcohols. Lipophilic 1,3,4-oxadiazole derivatives were obtained through the Mannich reactions between 5-(aryl)-1,3,4-oxadiazole-2-thiol and alkylated or acylated amines. The in vitro cytotoxic effects were evaluated against 4T1- mammary carcinoma and CT26 – colon cancer cells. The best results were obtained for the 1,3,4-oxadiazole coupled to alkylated piperazine with 10-14 carbon chain moiety, with IC50 values ranging from 1.6 to 3.55 mu M for the 4T1 cell line, and from 1.6 to 3.9 mu M for the CT26.WT cell line, and selectivity index up to 19. The most potent compounds were investigated with AnnexinV and PI staining as indicative of apoptosis induction. (C) 2019 Published by Elsevier Masson SAS.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Caneschi, W; Enes, KB; de Mendonca, CC; Fernandes, FD; Miguel, FB; Martins, JD; Le Hyaric, M; Pinho, RR; Duarte, LM; de Oliveira, MAL; Dos Santos, HF; Lopes, MTP; Dittz, D; Silva, H; Couri, MRC or concate me.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
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An article Novel Molecular Hybrids of N-Benzylpiperidine and 1,3,4-Oxadiazole as Multitargeted Therapeutics to Treat Alzheimer’s Disease WOS:000491219000019 published article about BETA-AMYLOID AGGREGATION; ACETYLCHOLINESTERASE INHIBITOR; ACID-DERIVATIVES; DIRECTED LIGANDS; DESIGN; PEPTIDE; ASSAY; SITE; BUTYRYLCHOLINESTERASE; NEUROTOXICITY in [Sharma, Piyoosh; Tripathi, Avanish; Tripathi, Prabhash Nath; Shrivastava, Sushant Kumar] Banaras Hindu Univ, Indian Inst Technol, Dept Pharmaceut Engn & Technol, Varanasi 221005, Uttar Pradesh, India; [Sen Singh, Saumitra; Singh, Surya Pratap] Banaras Hindu Univ, Fac Sci, Dept Biochem, Varanasi 221005, Uttar Pradesh, India in 2019, Cited 80. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Multitargeted hybrids of N-benzylpiperidine and substituted 5-phenyl-1,3,4-oxadiazoles were designed, synthesized, and evaluated against Alzheimer’s disease (AD). Tested compounds exhibited moderate to excellent inhibition against human acetylcholinesterase (hAChE), butyrylcholinesterase (hBChE), and beta-secretase-1 (hBACE-1). The potential leads 6g and 10f exhibited balanced inhibitory profiles against all the targets, with a substantial displacement of propidium iodide from the peripheral anionic site of hAChE. Hybrids 6g and 10f also elicited favorable permeation across the blood -brain barrier and were devoid of neurotoxic liability toward SH-SYSY neuroblastoma cells. Both leads remarkably disassembled A beta aggregation in thioflavin T-based selfand AChE-induced experiments. Compounds 6g and 10f ameliorated scopolamine gamma-induced cognitive dysfunctions in the Ymaze test. The ex vivo studies of rat brain homogenates established the reduced AChE levels and antioxidant activity of both compounds. Compound 6g also elicited noteworthy improvement in A beta-induced cognitive dysfunctions in the Morris water maze test with downregulation in the expression of A beta and BACE-1 proteins corroborated by Western blot and immunohistochemical analysis. The pharmacokinetic study showed excellent oral absorption characteristics of compound 6g. The in silica molecular docking and dynamics simulation studies of lead compounds affirmed their consensual binding interactions with PAS-AChE and aspartate dyad of BACE-1.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Sharma, P; Tripathi, A; Tripathi, PN; Sen Singh, S; Singh, SP; Shrivastava, SK or concate me.. Name: 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
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Recently I am researching about CASCADE REACTIONS; MICHAEL REACTION; CONDENSATIONS; CONSTRUCTION, Saw an article supported by the Shanghai Pujiang ProgramShanghai Pujiang Program [KBH1615505]. Name: 4-Nitrobenzoic acid. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Hu, S; Wang, JQ; Huang, GX; Zhu, KJ; Chen, F. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

An organocatalytic asymmetric enantioselective domino oxa-Michael-Mannich-[1,3]-amino rearrangement reaction of N-tosylsalicylimines with a wide range of alpha,beta-unsaturated aldehydes utilizing diarylprolinol silyl ether catalysis is described. The catalytic reactions proceed with excellent enantioselectivity (up to 99% ee) to produce the corresponding chair N-tosylimines-chromenes with a yield of up to 99%, tolerating a range of functional groups. This methodology offers a new method with great potential to further extend the synthetic power and versatility of chiral aminocatalysis.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hu, S; Wang, JQ; Huang, GX; Zhu, KJ; Chen, F or concate me.

Reference:
Phthalazine – Wikipedia,
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Recently I am researching about C-H BONDS; BENZOIC-ACID; MOLECULAR-OXYGEN; N-HYDROXYPHTHALIMIDE; SELECTIVE OXIDATION; METAL-FREE; PHOTOOXIDATION; DERIVATIVES; COBALT; OXIDE, Saw an article supported by the National Key Research and Development Program of China [2017YFC0210900]. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Zheng, K; Yan, XY; Zhang, GF; Yan, XH; Li, XQ; Xu, XS. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Safety of 4-Nitrobenzoic acid

A mild and metal-free procedure is reported for the aerobic oxidation of substituted toluenes to carboxylic acids by using CBr (4) as initiator under irradiation from a 400 nm blue light-emitting diode.

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Reference:
Phthalazine – Wikipedia,
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Recommanded Product: 62-23-7. In 2019 CHEM COMMUN published article about H AMIDATION; BOND AMIDATION; FUNCTIONALIZATION; ACTIVATION; AMINATION; 1H-INDAZOLES; COBALT(III); AZIDES; HETEROCYCLES; AZOBENZENES in [Yang, Jingshu; Hu, Xiao; Li, Xueyuan; Liu, Gang] Tsinghua Univ, Sch Pharmaceut Sci, Beijing 100084, Peoples R China; [Liu, Zijie; Dong, Yi] Chinese Acad Med Sci & Peking Union Med Coll, State Key Lab Bioact Subst & Funct Nat Med, Inst Mat Med, Beijing 100050, Peoples R China; [Liu, Zijie; Dong, Yi] Chinese Acad Med Sci & Peking Union Med Coll, Beijing Key Lab Active Subst Discovery & Druggabi, Inst Mat Med, Beijing 100050, Peoples R China in 2019, Cited 83. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A Cp*Co-III-catalyzed arene C-H bond amidation/annulation of benzamides was developed to afford quinazolinone derivatives in one-pot with high yields and broad substrate scope. This method could be applied to the synthesis of quinazolinone drugs and late-stage modification of natural products.

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Reference:
Phthalazine – Wikipedia,
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Computed Properties of C7H5NO4. In 2020 J ORG CHEM published article about CIRCULARLY-POLARIZED LUMINESCENCE; PROBES; DERIVATIVES; VERSATILE; SOLVENT; DESIGN; STATE; RED in [Banuelos, Jorge; Arbeloa, Teresa] Univ Basque Country, EHU, Dept Quim Fis, Fac Ciencia & Tecnol, E-48080 Bilbao, Spain; [Ray, Cesar; Schad, Christopher; Moreno, Florencio; Maroto, Beatriz L.; de la Moya, Santiago] Univ Complutense Madrid, Dept Quim Organ, Fac Ciencias Quim, E-28040 Madrid, Spain; [Garcia-Moreno, Inmaculada] CSIC, Inst Quim Fis Rocasolano, Dept Sistemas Baja Dimensionalidad Superficies &, E-28006 Madrid, Spain; [Villafuerte, Cassie; Muller, Gilles] San Jose State Univ, Dept Chem, San Jose, CA 95192 USA in 2020, Cited 39. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A general and straightforward method for the synthesis of COO-BODIPYs from F-BODIPYs and carboxylic acids is established. The method is based on the use of boron trichloride to activate the involved substitution of fluorine, which leads to high yields through rapid reactions under soft conditions. This mild method opens the way to unprecedented laser dyes with outstanding efficiencies and photostabilities, which are difficult to obtain by the current methods.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Ray, C; Schad, C; Moreno, F; Maroto, BL; Banuelos, J; Arbeloa, T; Garcia-Moreno, I; Villafuerte, C; Muller, G; de la Moya, S or concate me.. Computed Properties of C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Metal-Free Synthesis of Indolopyrans and 2,3-Dihydrofurans Based on Tandem Oxidative Cycloaddition WOS:000551552600048 published article about PICTET-SPENGLER REACTIONS; SP(3) C-H; INDOLE SYNTHESIS; IODINE(III) REAGENTS; AMINATION; EFFICIENT; FUNCTIONALIZATION; BONDS; TETRAHYDROISOQUINOLINES; ALKYLATION in [Choi, Subin; Oh, Hyeonji; Sim, Jeongwoo; Yu, Eunsoo; Park, Cheol-Min] UNIST Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea; [Shin, Seunghoon] Hanyang Univ, Dept Chem, Seoul 04763, South Korea in 2020.0, Cited 73.0. Name: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The synthesis of versatile scaffold indolopyrans based on C-C radical-radical cross-coupling under metal-free conditions is described. The reaction involving single electron transfer between coupling partners followed by cage collapse allows highly selective cross-coupling while employing only equimolar amounts of coupling partners. Moreover, the mechanistic manifold was expanded for the functionalization of enamines to give the stereoselective synthesis of 2,3-dihydrofurans. This iodine-mediated oxidative coupling features mild conditions and fast reaction kinetics.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem