About 4-Nitrobenzoic acid, If you have any questions, you can contact Caneschi, W; Enes, KB; de Mendonca, CC; Fernandes, FD; Miguel, FB; Martins, JD; Le Hyaric, M; Pinho, RR; Duarte, LM; de Oliveira, MAL; Dos Santos, HF; Lopes, MTP; Dittz, D; Silva, H; Couri, MRC or concate me.. Application In Synthesis of 4-Nitrobenzoic acid
An article Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles WOS:000459358600003 published article about BIOLOGICAL EVALUATION; DERIVATIVES SYNTHESIS; MOLECULAR DOCKING; INHIBITORS; APOPTOSIS; MOIETY; TOXICITY; ANALOGS; GROWTH; POTENT in [Caneschi, Wiliam; Enes, Karine Braga; de Mendonca, Camille Carvalho; Fernandes, Fabio de Souza; Miguel, Fabio Balbino; Le Hyaric, Mireille; Duarte, Lucas Mattos; Leal de Oliveira, Marcone Augusto; Dos Santos, Hello F.; Costa Couri, Mara Rubia] Univ Fed Juiz de Fora, Dept Quim, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil; [Martins, Jefferson da Silva; Pinho, Roberto Rosas] Univ Fed Juiz de Fora, Dept Fis, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil; [Paz Lopes, Miriam Teresa; Dittz, Dalton] Univ Fed Minas Gerais, ICB, Dept Farmacol, BR-31270901 Belo Horizonte, MG, Brazil; [Silva, Heveline] Univ Fed Minas Gerais, Dept Quim, BR-31270901 Belo Horizonte, MG, Brazil in 2019.0, Cited 37.0. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7
A series of1,2,4- and 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Halogenated 1,2,4-oxadiazoles were obtained from benzonitrile and coupled either lipophilic amines or with aminoalcohols. Lipophilic 1,3,4-oxadiazole derivatives were obtained through the Mannich reactions between 5-(aryl)-1,3,4-oxadiazole-2-thiol and alkylated or acylated amines. The in vitro cytotoxic effects were evaluated against 4T1- mammary carcinoma and CT26 – colon cancer cells. The best results were obtained for the 1,3,4-oxadiazole coupled to alkylated piperazine with 10-14 carbon chain moiety, with IC50 values ranging from 1.6 to 3.55 mu M for the 4T1 cell line, and from 1.6 to 3.9 mu M for the CT26.WT cell line, and selectivity index up to 19. The most potent compounds were investigated with AnnexinV and PI staining as indicative of apoptosis induction. (C) 2019 Published by Elsevier Masson SAS.
About 4-Nitrobenzoic acid, If you have any questions, you can contact Caneschi, W; Enes, KB; de Mendonca, CC; Fernandes, FD; Miguel, FB; Martins, JD; Le Hyaric, M; Pinho, RR; Duarte, LM; de Oliveira, MAL; Dos Santos, HF; Lopes, MTP; Dittz, D; Silva, H; Couri, MRC or concate me.. Application In Synthesis of 4-Nitrobenzoic acid
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem