Month: October 2021

In 2019 RUSS J GEN CHEM+ published article about ANTITUMOR EFFICACY; DERIVATIVES in [Amperayani, K. R.; Parimi, U. D.] GVP Degree & PG Coll, Dept Chem, Visakhapatnam 530045, Andhra Pradesh, India in 2019, Cited 25. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

Piperine is a component of pepper which has earlier been reported as anticancer active compound. This work is emphasized on the design and synthesis of new hybrid piperine analogs by coupling piperine with the amine group of oxadiazoles and thiadiazoles. The new series of twelve piperine analogs was been tested for in vitro anti-proliferative activity using sulforhodamine B (SRB) assay test against MCF-7, PC-3, and HeLa cell lines. Among the twelve synthesised molecules piperine derivative with oxadiazole baring hydroxyl group (3) exhibits the higher activity against MCF-7 cell line than the reference drug Adriamycin and also displays the highest binding energy in the in silico studies. The other analogs are moderately active.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Amperayani, KR; Parimi, UD or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 ASIAN J ORG CHEM published article about NONACTIVATED CARBOXYLIC-ACIDS; CHEMISTRY RESEARCH AREAS; DIRECT AMIDATION; ALPHA,BETA-UNSATURATED AMIDES; C-O; AMINES; SUBSTITUTION; PERSPECTIVE; GENERATION; AMINATION in [Xu, Yiwen; Xu, Xiuzhi; Wu, Bin; Gan, Chenling; Lin, Xiaoyan; Wang, Jin; Ke, Fang] Fujian Med Univ, Inst Mat Med, Sch Pharm, Fujian Prov Key Lab Nat Med Pharmacol, Fuzhou 350122, Peoples R China in 2020, Cited 77. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

A visible-light-catalyzed radical N-acylation of amines with carboxylic acids was achieved by means of eosin Y as the photocatalyst under aqueous medium without any transition-metal-based catalytic systems. The new method takes advantages of visible-light photocatalysis to generate the amides under mild conditions. A variety of amides have been synthesized in good to excellent yields. Moreover, the strategy was successfully applied in the preparation of paracetamol.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Xu, YW; Xu, XZ; Wu, B; Gan, CL; Lin, XY; Wang, J; Ke, F or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Product Details of 62-23-7. In 2019 BIOORG MED CHEM LETT published article about IN-VITRO; NATURAL-PRODUCT; PANAX-GINSENG; CANCER; GINSENOSIDES; 20(S)-25-METHOXYL-DAMMARANE-3-BETA; 20-TRIOL; 12-BETA; VIVO in [Qu, Fan-Zhi; Xiao, Sheng-Nan; Wang, Xu-De; Zhang, Yan; Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China; [Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China in 2019, Cited 26. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Previously we have reported that 25-OCH3-PPD could suppress the reproduction of cancer cells and cause apoptosis without obvious toxicity. Herein, we aimed to enhance its bioactivity by introducing aromatic groups to its dammarane-type skeleton. These synthesized derivatives were tested for their inhibitory activities against five cancer cell lines. Of them, compounds 3a, 14a and 18a had the strongest antiproliferative activities against tumor cells (IC50 < 15 mu M, 5-fold to 10-fold increases than 25-OCH3-PPD). Especially compound 14a displayed the most potent activity against DU145, MCF-7 and HepG2 cells (IC50 = 6.7 +/- 0.8, 4.3 +/- 0.8 and 5.8 +/- 0.6 mu M, respectively). Structure-activity relationships demonstrated that having aromatic ester at the C3 position could improve the bioactivity. The data provided new insights into exploring novel antiproliferative lead compounds. Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Qu, FZ; Xiao, SN; Wang, XD; Zhang, Y; Su, GY; Zhao, YQ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Metal-free alkene carbooxygenation following tandem intramolecular alkoxylation/Claisen rearrangement: stereocontrolled access to bridged [4.2.1] lactones WOS:000461509800030 published article about GOLD-CATALYZED SYNTHESIS; EFFICIENT SYNTHESIS; CHIRALITY TRANSFER; CYCLIZATION; YNAMIDES; CYCLOISOMERIZATION; CYCLOADDITION; CONSTRUCTION; CARBON; ACID in [Li, Long; Zhu, Xin-Qi; Zhang, Ying-Qi; Bu, Hao-Zhen; Yuan, Peng; Ye, Long-Wu] Xiamen Univ, Coll Chem & Chem Engn, Key Lab Chem Biol Fujian Prov, State Key Lab Phys Chem Solid Surfaces, Xiamen 361005, Peoples R China; [Chen, Jinyu; Su, Jingyi; Deng, Xianming] Xiamen Univ, Sch Life Sci, State Key Lab Cellular Stress Biol, Xiamen 361102, Fujian, Peoples R China; [Ye, Long-Wu] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Organometall Chem, Shanghai 200032, Peoples R China; [Ye, Long-Wu] Nankai Univ, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China in 2019.0, Cited 78.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4

Alkene carbooxygenation has attracted considerable attention over the past few decades as this approach provides an efficient access to various oxygen-containing molecules, especially the valuable O-heterocycles. However, examples of catalytic alkene carbooxygenation via a direct C-O cleavage are quite scarce, and the C-O cleavage in these cases is invariably initiated by transition metal-catalyzed oxidative addition. We report here a novel Bronsted acid-catalyzed intramolecular alkoxylation-initiated tandem sequence, which represents the first metal-free intramolecular alkoxylation/Claisen rearrangement. Significantly, an unprecedented Bronsted acid-catalyzed intramolecular alkene insertion into the C-O bond via a carbocation pathway was discovered. This method allows the stereocontrolled synthesis of valuable indole-fused bridged [4.2.1] lactones, providing ready access to biologically relevant scaffolds in a single synthetic step from an acyclic precursor. Moreover, such an asymmetric cascade cyclization has also been realized by employing a traceless chiral directing group. Control experiments favor the feasibility of a carbocation pathway for the process. In addition, biological tests showed that some of these newly synthesized indole-fused lactones exhibited their bioactivity as antitumor agents against different breast cancer cells, melanoma cells, and esophageal cancer cells.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Li, L; Zhu, XQ; Zhang, YQ; Bu, HZ; Yuan, P; Chen, JY; Su, JY; Deng, XM; Ye, LW or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. In 2019 BIOORG MED CHEM LETT published article about IN-VITRO; NATURAL-PRODUCT; PANAX-GINSENG; CANCER; GINSENOSIDES; 20(S)-25-METHOXYL-DAMMARANE-3-BETA; 20-TRIOL; 12-BETA; VIVO in [Qu, Fan-Zhi; Xiao, Sheng-Nan; Wang, Xu-De; Zhang, Yan; Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Shenyang 110016, Liaoning, Peoples R China; [Su, Guang-Yue; Zhao, Yu-Qing] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China in 2019, Cited 26. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Previously we have reported that 25-OCH3-PPD could suppress the reproduction of cancer cells and cause apoptosis without obvious toxicity. Herein, we aimed to enhance its bioactivity by introducing aromatic groups to its dammarane-type skeleton. These synthesized derivatives were tested for their inhibitory activities against five cancer cell lines. Of them, compounds 3a, 14a and 18a had the strongest antiproliferative activities against tumor cells (IC50 < 15 mu M, 5-fold to 10-fold increases than 25-OCH3-PPD). Especially compound 14a displayed the most potent activity against DU145, MCF-7 and HepG2 cells (IC50 = 6.7 +/- 0.8, 4.3 +/- 0.8 and 5.8 +/- 0.6 mu M, respectively). Structure-activity relationships demonstrated that having aromatic ester at the C3 position could improve the bioactivity. The data provided new insights into exploring novel antiproliferative lead compounds. Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Qu, FZ; Xiao, SN; Wang, XD; Zhang, Y; Su, GY; Zhao, YQ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about CHEMOSELECTIVE HYDROGENATION; PD NANOPARTICLES; NITRO-COMPOUNDS; REDUCTION; PERFORMANCE; NITROAROMATICS; EXPLORATION; INTERFACES; HYDRAZINE; COMPOSITE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21872020, 81872835, 21621003]; Ministry of Science and Technology [2017YFC0906902, 2017ZX09301032]; China Scholarship CouncilChina Scholarship Council [201806085012]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Tian, HM; Zhou, JJ; Li, YN; Wang, YM; Liu, L; Ai, YJ; Hu, ZN; Li, JF; Guo, RX; Liu, ZB; Sun, HB; Liang, QL. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Name: 4-Nitrobenzoic acid

Modifying the surface of metal catalyst is a crucial subject for improving the heterogeneous metal catalysts. It is still a great challenge to understand the structure-activity relationship (SAR) between the surface supporting groups and the metal particles. Herein, Rh NPs supported on the magnetic silica sphere with various functional groups (-NH2, -SH, -SO3H, -N=CH2, -Cl, -NHCOCH3 and -NHCH2Ph) have been prepared for catalytic hydrogenation of nitroarenes under atmospheric pressure at room temperature. We discover that the chemical state of Rh NPs depends on the supporting groups significantly. The electron-donating functionalities can effectively elevate the Rh-0/Rh3+ ratio, which increase the catalytic performance both in conversion and selectivity. The amino group decorated catalyst has such a good selectivity that no dechlorination reaction is observable in the hydrogenation of 2-chloro-3-nitropyridine. What’s more, by introducing magnetic Fe3O4 nuclei and mesoporous silica encapsulating layer, the catalyst can be recovered conveniently by an external magnet, and can be reused 10 cycles without any loss of activity.

Name: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Tian, HM; Zhou, JJ; Li, YN; Wang, YM; Liu, L; Ai, YJ; Hu, ZN; Li, JF; Guo, RX; Liu, ZB; Sun, HB; Liang, QL or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. Recently I am researching about LIGANDS; HYDROGENATION; STEREOSELECTIVITY; PHOSPHINES; OXIDATION; ALCOHOLS; ACID, Saw an article supported by the National Science CentreNational Science Centre, Poland [2012/07/N/ST5/02194]. Published in BEILSTEIN-INSTITUT in FRANKFURT AM MAIN ,Authors: Kmieciak, A; Krzeminski, MP. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

New chiral regioisomeric gamma-hydroxyphosphine ligands were synthesized from alpha-pinene. The key transformation was the thermal [2,3]-sigmatropic rearrangement of allyldiphenylphosphinites, obtained from (1R,2R,4S,5R)-3-methyleneneoisoverbanol and (1R,2R,3R,5R)-4-methyleneneoisopinocampheol, to allylphosphine oxides. Hydroxy groups were introduced stereoselectively through a hydroboration-oxidation reaction proceeding from the less hindered site providing a trans relationship between the hydroxy and the phosphine substituents.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Kmieciak, A; Krzeminski, MP or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Zn(0)-Catalysed mild and selective hydrogenation of nitroarenes published in 2020.0, Reprint Addresses Wang, B (corresponding author), Hainan Univ, Minist Educ, Key Lab Adv Mat Trop Isl Resources, 58 Renmin AVE, Haikou 570228, Hainan, Peoples R China.; Wang, B (corresponding author), Shandong Agr Univ, Coll Sci & Engn, 7 Panhe AVE, Tai An 271017, Shandong, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

The hydrogenation of nitroarenes is one of the most important strategies for the preparation of anilines. However, it is still a great challenge to develop mild and efficient synthetic routes toward aniline synthesis, particularly those employing both non-precious metal catalysts and low-pressure H-2. Herein, we report a highly efficient protocol for the selective hydrogenation of nitroarenes in neutral H2O using H-2(1 atm) over a heterogeneous Zn(0) catalyst under mild conditions. The nitro groups of an array of nitroarenes can be converted into -NH(2)with up to 99% conversions and a selectivity of >99%, even when functionalized with easily reducible substituents, or in the presence of aromatic ketones or styrene. This study might open an avenue for the selective hydrogenation of nitroarenes over a zinc catalyst using 1 atm H-2.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Sun, ST; Du, MY; Zhao, RX; Jv, XC; Hu, P; Zhang, Q; Wang, B or concate me.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Photoinduced Divergent Alkylation/Acylation of Pyridine N-Oxides with Alkynes under Anaerobic and Aerobic Conditions WOS:000474795200083 published article about PHOTOREDOX-CATALYSIS; FUNCTIONALIZATION; ALPHA; AMIDOALKYLATION; ETHERS in [Xu, Jin-hui; Wu, Wen-bin; Wu, Jie] Natl Univ Singapore, Dept Chem, 3 Sci Dr 3, Singapore 117543, Singapore in 2019.0, Cited 47.0. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Ortho-alkylated and ortho-acylated pyridines have been conveniently synthesized from pyridine N-oxides and alkynes under visible-light-mediation in a metal-free manner. The alkynes served as both alkylating and acylating agents via switching between anaerobic and aerobic conditions. The overall strategy accommodates a broad scope of substituted pyridine N-oxides and alkynes, with excellent regioselectivity in a number of cases.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Xu, JH; Wu, WB; Wu, J or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. In 2020.0 ADV OPT MATER published article about METAL-ORGANIC FRAMEWORK; CRYSTAL TRANSFORMATION; SELECTIVE DETECTION; ENERGY-TRANSFER; MOF; SENSORS; LIGAND; COMPOSITE; REMOVAL; IONS in [Gao, Enjun] Univ Sci & Technol Liaoning, Sch Chem Engn, Anshan 114051, Liaoning, Peoples R China; [Gao, Enjun; Wu, Shuangyan; Wang, Jing; Zhu, Mingchang; Zhang, Ying] Shenyang Univ Chem Technol, Key Lab Inorgan Mol Based Chem Liaoning Prov, 11th St, Shenyang 110142, Liaoning, Peoples R China; [Gao, Enjun; Wu, Shuangyan; Wang, Jing; Zhu, Mingchang; Zhang, Ying] Shenyang Univ Chem Technol, Lab Coordinat Chem, 11th St, Shenyang 110142, Liaoning, Peoples R China; [Fedin, Vladimir P.] Nikolaev Inst Inorgan Chem, Lavrentiev Ave 3, Novosibirsk 630090, Russia in 2020.0, Cited 86.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Conventional luminescent sensors relying on single emission responsive to analytes demonstrate limited sensitivity and selectivity and developing novel self-calibration probes is highly required. A series of water-stable coordination polymers (CPs) with three emitting centers for tunable emissions is reported. They are facilely synthesized by simultaneously doping red-emitting Eu3+ and green-emitting Tb3+ into the same framework. The versatile Eu0.67Tb0.33-CP is applied to conveniently distinguishing different nitroaromatics pollutants and multidimensional ratiometric sensing CrO42-/Cr2O72-. Specific nitroaromatics can cause unique changes to the ligand -> Eu3+/Tb3+ energy transfer efficiency, while CrO42-/Cr2O72- intriguingly quench the three emissions at different rates. Each nitroaromatic exhibits notably correlation to a unique combination of the two ligand -> Eu3+/Tb3+ emission intensity ratios, enabling a 2D fingerprint recognition. Furthermore, the concentration-dependent evolution of the two ratios upon exposure to CrO42-/Cr2O72- can be mapped out, achieving a 3D code recognition. As a result, the sensor demonstrates selective recognition of 4-nitrophenol and CrO42-/Cr2O72- with high sensitivity and selectivity as well as great recycling ability. Both the synthetic and sensing strategies present a promising strategy to develop facile and effective ratiometric sensors.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Gao, EJ; Wu, SY; Wang, J; Zhu, MC; Zhang, Y; Fedin, VP or concate me.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem