Month: October 2021

An article Buchwald-Hartwig versus Microwave-Assisted Amination of Chloroquinolines: En Route to the Pyoverdin Chromophore WOS:000545628800009 published article about PSEUDOMONAS-AERUGINOSA; SIDEROPHORES; BIOSYNTHESIS in [Seubert, Philipp; Freund, Marcel; Rudolf, Richard; Lin, Yulin; Altevogt, Luca; Baro, Angelika; Laschat, Sabine] Univ Stuttgart, Inst Organ Chem, Pfaffenwaldring 55, D-70569 Stuttgart, Germany; [Altevogt, Luca; Bilitewski, Ursula] Helmholtz Zentrum Infekt Forsch, AG Compound Profiling & Screening, Inhoffenstr 7, D-38124 Braunschweig, Germany in 2020.0, Cited 20.0. Application In Synthesis of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The reaction of 2-chloro-6,7-dimethoxy-3-nitroquinoline with a series of amines and aminoalkanoates under basic microwave-mediated conditions and under Buchwald-Hartwig amination conditions is reported. The microwave irradiation favored the reaction with amines, resulting in yields of up to 80%, whereas amino acid functionalization gave yields comparable to those of Buchwald-Hartwig amination. tert-Butyl (2R)-4-[(6,7-dimethoxy-3-nitroquinolin-2-yl)amino]-2-hydroxybutanoate was successfully cyclized to the pyoverdin chromophore, a subunit of siderophores.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Seubert, P; Freund, M; Rudolf, R; Lin, YL; Altevogt, L; Bilitewski, U; Baro, A; Laschat, S or concate me.. Application In Synthesis of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis of Nitrogen-Containing Goniothalamin Analogues with Higher Cytotoxic Activity and Selectivity against Cancer Cells published in 2019.0, Reprint Addresses Pilli, RA (corresponding author), Univ Estadual Campinas, UNICAMP, Inst Chem, Dept Organ Chem, BR-13083970 Campinas, SP, Brazil.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Two series of racemic goniothalamin analogues displaying nitrogen-containing groups were designed and synthesized. A total of 19 novel analogues were evaluated against a panel of four different cancer cell lines, along with the normal prostate cell line PNT2 to determine their selectivity. Among them, goniothalamin chloroacrylamide 13 e displayed the lowest IC50 values for both MCF-7 (0.5 mu m) and PC3 (0.3 mu m) cells, about 26-fold more potent than goniothalamin (1). Besides its higher potency, compound 13 e also displayed much higher selectivity than goniothalamin. In contrast, goniothalamin isobutyramide 13 c was the most potent analogue against Caco-2 cells (IC50=0.8 mu m), about 10-fold more potent and 17-fold more selective than 1. These results reveal the potential of compounds 13 c and 13 e for further in vivo studies, representing the first goniothalamin analogues with IC50 values in the low micromolar range and high selectivity against MCF-7, Caco-2, and PC3 cancer cell lines.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Meirelles, MA; Braga, CB; Ornelas, C; Pilli, RA or concate me.. Category: phthalazines

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Heterogeneous Suzuki-Miyaura coupling of heteroaryl ester via chemoselective C(acyl)-O bond activation WOS:000471912700036 published article about CATALYZED C-O; ARYL ESTERS; NICKEL; AZOLES; SILYLATION; AMINATION; CLEAVAGE; KETONES; AMIDE in [Ma, Hongpeng; Bai, Chaolumen; Bao, Yong-Sheng] Inner Mongolia Normal Univ, Coll Chem & Environm Sci, Inner Mongolia Key Lab Green Catalysis, Hohhot 010022, Peoples R China in 2019, Cited 47. Recommanded Product: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

A site-selective supported palladium nanoparticle catalyzed Suzuki-Miyaura cross-coupling reaction with heteroaryl esters and arylboronic acids as coupling partners was developed. This methodology provides a heterogeneous catalytic route for aryl ketone formation via C(acyl)-O bond activation of esters by successful suppression of the undesired decarbonylation phenomenon. The catalyst can be reused and shows high activity after eight cycles. The XPS analysis of the catalyst before and after the reaction suggested that the reaction might be performed via a Pd-0/Pd-II catalytic cycle that began with Pd-0.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, HP; Bai, CLM; Bao, YS or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Application In Synthesis of 4-Nitrobenzoic acid. I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis and anticancer evaluation of new lipophilic 1,2,4 and 1,3,4-oxadiazoles published in 2019.0, Reprint Addresses Couri, MRC (corresponding author), Univ Fed Juiz de Fora, Dept Quim, ICE, Campus Martelo, BR-36036330 Juiz De Fora, MG, Brazil.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A series of1,2,4- and 1,3,4-oxadiazole derivatives were synthesized and evaluated for their anticancer activity. Halogenated 1,2,4-oxadiazoles were obtained from benzonitrile and coupled either lipophilic amines or with aminoalcohols. Lipophilic 1,3,4-oxadiazole derivatives were obtained through the Mannich reactions between 5-(aryl)-1,3,4-oxadiazole-2-thiol and alkylated or acylated amines. The in vitro cytotoxic effects were evaluated against 4T1- mammary carcinoma and CT26 – colon cancer cells. The best results were obtained for the 1,3,4-oxadiazole coupled to alkylated piperazine with 10-14 carbon chain moiety, with IC50 values ranging from 1.6 to 3.55 mu M for the 4T1 cell line, and from 1.6 to 3.9 mu M for the CT26.WT cell line, and selectivity index up to 19. The most potent compounds were investigated with AnnexinV and PI staining as indicative of apoptosis induction. (C) 2019 Published by Elsevier Masson SAS.

Application In Synthesis of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Caneschi, W; Enes, KB; de Mendonca, CC; Fernandes, FD; Miguel, FB; Martins, JD; Le Hyaric, M; Pinho, RR; Duarte, LM; de Oliveira, MAL; Dos Santos, HF; Lopes, MTP; Dittz, D; Silva, H; Couri, MRC or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 ORG LETT published article about DIELS-ALDER REACTIONS; CHIRAL PHOSPHORIC-ACID; LEWIS-ACID; BRONSTED ACID; ONE-POT; TETRAHYDROQUINOLINES; EFFICIENT; MECHANISM; CLOSURE; ACCESS in [Huang, Jun-Xiang; Hou, Ke-Qiang; Hu, Qi-Long; Chen, Xue-Ping; Li, Jian; Chan, Albert S. C.; Xong, Xiao-Feng] Sun Yat Sen Univ, Sch Pharmaceut Sci, Guangdong Key Lab Chiral Mol & Drug Discovery, Guangzhou 510006, Peoples R China in 2020.0, Cited 57.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4

We report the first highly enantio- and diastereoselective three-component Povarov reaction between anilines and aldehydes catalyzed by a chiral amine catalyst. A wide variety of substituted tetrahydroquinolines were obtained with moderate to good yields and excellent enantioselectivity and diastereoselectivity (up to 99% ee and >95:5 dr) under the reaction conditions. Furthermore, the reaction intermediates could be efficiently converted to other valuable building blocks.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Huang, JX; Hou, KQ; Hu, QL; Chen, XP; Li, J; Chan, ASC; Xong, XF or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Direct Carbohydroxylation of Arylalkenes with Allylic Alcohols: Cooperative Catalysis of Copper, Silver, and a Bronsted Acid WOS:000458417700056 published article about H BOND FUNCTIONALIZATION; CROSS-COUPLING REACTIONS; ALKENES; PALLADIUM; MECHANISM; OLEFINS; STYRENES; GOLD; MARKOVNIKOV; DERIVATIVES in [Ahmed, Waqar; Zhang, Sheng; Yu, Xiaoqiang; Feng, Xiujuan; Yamamoto, Yoshinori; Bao, Ming] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Peoples R China; [Ahmed, Waqar; Zhang, Sheng; Yu, Xiaoqiang; Feng, Xiujuan; Yamamoto, Yoshinori; Bao, Ming] Dalian Univ Technol, Sch Petr & Chem Engn, Panjin 124221, Peoples R China; [Yamamoto, Yoshinori] Ritsumeikan Univ, Res Org Sci & Technol, Shiga 5258577, Japan in 2019.0, Cited 75.0. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The cooperative catalysis of copper, silver, and Bronsted acid is presented as a new strategy for olefin functionalization. The catalytic direct carbohydroxylation of arylalkenes with allylic alcohols provided a straightforward and efficient approach for preparing 4,5-unsaturated alcohols. Synthetically useful functional groups, such as Cl, Br, carbonyl, and chloromethyl, remained intact during the functionalization reaction.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ahmed, W; Zhang, S; Yu, XQ; Feng, XJ; Yamamoto, Y; Bao, M or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article N-Amino-7-azaindole as the N,N’-Bidentate Directing Group: Ruthenium-Catalyzed Oxidative Annulation of N-(7-Azaindole)benzamides with Alkynes via C-H Bond Activation WOS:000489201000007 published article about COBALT; FUNCTIONALIZATION; ALKENYLATION; HYDRAZINES; AMINATION; ARYLATION; CLEAVAGE; INDOLES in [Sagara, Prateep Singh; Siril, Prem Felix] Indian Inst Technol Mandi, Sch Basic Sci, Mandi 175005, Himachal Prades, India; [Ravikumar, Ponneri Chandrababu] Natl Inst Sci Educ & Res NISER Bhubaneswar, Sch Chem Sci, Jatani Campus, Bhubaneswar 752050, Odisha, India in 2019, Cited 29. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We report a new application of N-amino-7-azaindole as a new bidentate-directing group for [Ru(p-cymene)Cl-2](2)-catalyzed C(sp(2))-H alkenylation/annulation of N-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamides with internal alkynes to afford N-isoquinolono-7-azaindole via the formation of C-C and C-N bonds. The reaction shows a wide range of substrate scope with different symmetrical and unsymmetrical alkynes, affording the desired product in good to excellent yields. In the case of unsymmetrical alkynes, a highly regioselective product was obtained, which was confirmed by single-crystal X-ray crystallography. A new ruthenium-4-methyl-N-(1H-pyrrolo[2,3-b]pyridin-1-yl)benzamide complex was isolated, and its structure was confirmed by single-crystal X-ray crystallography.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Sagara, PS; Siril, PF; Ravikumar, PC or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about ENANTIOSELECTIVE CONSTRUCTION; 1,3-DIPOLAR CYCLOADDITIONS; NANOPARTICLES; EFFICIENT; OXAZOLE; ANTIBACTERIAL; HETEROCYCLES; CHEMISTRY; FRAMEWORK, Saw an article supported by the . Published in SPRINGER in DORDRECHT ,Authors: Abdolmohammadi, S; Hossaini, Z. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Product Details of 62-23-7

In the present study, iron oxide magnetic nanoparticles (Fe3O4 MNPs) were synthesized in a green biosynthetic manner using aqueous extract of clover leaves. Fe3O4 MNPs were applied as a magnetically separable nanocatalyst for the green syntheses of functionalized [1,3]-oxazoles 1(a-e) and 1H-pyrrolo-[1,3]-oxazoles 4(a-i) as promising antioxidant compounds in excellent yields at 50 degrees C and room temperature, respectively. The antioxidant activities of the most stable compounds (1a, 1b, 4a, and 4b) were evaluated by both 2,2-diphenyl-1-picrylhydrazyl radical scavenging and ferric reduction activity potential assays. Compound 1b was shown a remarkable radical scavenging activity, and 4a was shown very good reducing activity relative to standards (BHT and TBHQ). [GRAPHICS] .

Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Abdolmohammadi, S; Hossaini, Z or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of Phosphonomethyl Tetrahydrofurans via the Mori- Tamaru Reaction of Phosphonodienes WOS:000535292300019 published article about NICKEL-CATALYZED HOMOALLYLATION; STEREOSELECTIVE-SYNTHESIS; C-NUCLEOSIDES; ANALOGS; ROUTE; DERIVATIVES; 1,3-DIENE; ALDEHYDES; PHOSPHONATE; CYCLIZATION in [Paudel, Rishi R.; Ridenour, Jeremy N.; Rath, Nigam P.; Spilling, Christopher D.] Univ Missouri, Dept Chem & Biochem, St Louis, MO 63121 USA in 2020.0, Cited 54.0. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Nickel-catalyzed reductive addition of phosphono-dienes to aldehydes (the Mori-Tamaru reaction) gives hydroxyvinyl phosphonates in good yields with excellent control of the relative stereochemistry. Base-induced cyclization of the vinyl phosphonates yields phosphonomethyl-substituted tetrahydrofurans. Inversion of the hydroxyl stereochemistry by Mitsunobu reaction and then cyclization yields a different set of phosphonomethyl-substituted tetrahydrofuran diastereoisomers.

Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Paudel, RR; Ridenour, JN; Rath, NP; Spilling, CD or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis of 3-[5-(Substituted Phenyl)-[1,3,4] Oxadiazol-2-yl]-1H-Indazole WOS:000486742400001 published article about CROSS-COUPLING REACTION; SUBSTITUTED INDAZOLES; BIOLOGICAL EVALUATION; EFFICIENT SYNTHESIS; CATALYZED SYNTHESIS; FLEXIBLE STRATEGY; MOLECULAR DOCKING; 2H-INDAZOLES; MILD; 1H-INDAZOLES in [Raut, S. V.; Tidke, A. D.; Pathan, Mohd Arif] Maulana Azad Coll Arts Sci & Commerce, Dept Chem, Aurangabad 431001, Maharashtra, India; [Dhotre, B. K.] Swami Vivekanand Sr Coll, Dept Chem, Mantha, Maharashtra, India in 2021, Cited 48. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

In the present investigation, we have reported the synthesis of a series of novel 3-(5-substituted-[1,3,4] oxadiazol-2-yl)-1H-indazole in good yields. 1H-indazole-3-carboxylic acid is converted to their respective esters, which on reaction with hydrazine hydrate afford 1H-indazole-3-carboxylic acid hydrazide. The reaction between 1H-indazole-3-carboxylic acid hydrazide with different substituted benzoic acids in the presence of cyclization agent phosphorus oxychloride gave aimed products in good yields.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Raut, SV; Tidke, AD; Dhotre, BK; Pathan, MA or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem