Month: October 2021

An article Direct Carbohydroxylation of Arylalkenes with Allylic Alcohols: Cooperative Catalysis of Copper, Silver, and a Bronsted Acid WOS:000458417700056 published article about H BOND FUNCTIONALIZATION; CROSS-COUPLING REACTIONS; ALKENES; PALLADIUM; MECHANISM; OLEFINS; STYRENES; GOLD; MARKOVNIKOV; DERIVATIVES in [Ahmed, Waqar; Zhang, Sheng; Yu, Xiaoqiang; Feng, Xiujuan; Yamamoto, Yoshinori; Bao, Ming] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Peoples R China; [Ahmed, Waqar; Zhang, Sheng; Yu, Xiaoqiang; Feng, Xiujuan; Yamamoto, Yoshinori; Bao, Ming] Dalian Univ Technol, Sch Petr & Chem Engn, Panjin 124221, Peoples R China; [Yamamoto, Yoshinori] Ritsumeikan Univ, Res Org Sci & Technol, Shiga 5258577, Japan in 2019.0, Cited 75.0. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The cooperative catalysis of copper, silver, and Bronsted acid is presented as a new strategy for olefin functionalization. The catalytic direct carbohydroxylation of arylalkenes with allylic alcohols provided a straightforward and efficient approach for preparing 4,5-unsaturated alcohols. Synthetically useful functional groups, such as Cl, Br, carbonyl, and chloromethyl, remained intact during the functionalization reaction.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Ahmed, W; Zhang, S; Yu, XQ; Feng, XJ; Yamamoto, Y; Bao, M or concate me.. Quality Control of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines. I found the field of Chemistry very interesting. Saw the article Amine decorated polystyrene nanobeads incorporating pi-conjugated OPV chromophore for picric acid sensing in water published in 2020.0, Reprint Addresses Makkad, SK (corresponding author), Govt Autonomous NPG Coll Sci, Raipur, Madhya Pradesh, India.; Makkad, SK (corresponding author), Natl Chem Lab, CSIR, Pune, Maharashtra, India.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A solution as well as solid state based sensor has been developed for selective detection of picric acid (PA) in water. Oligo (p-phenylenevinylene) (OPV) incorporated polystyrene nanobeads (PS-OPV-NH2) having an average size of 180 nm have been synthesized through miniemulsion polymerization. Amine (-NH2) functionalization was performed on the nanobead surface to enhance the efficiency of the sensor among a library of other nitro-organics and library of cations and anions.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Makkad, SK or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Safety of 4-Nitrobenzoic acid. I found the field of Chemistry very interesting. Saw the article Unprecedented Mechanism of an Organocatalytic Route to Conjugated Enynes with a Junction to Cyclic Nitronates published in 2019, Reprint Addresses Gschwind, RM (corresponding author), Univ Regensburg, Fac Chem & Pharm, Univ Str 31, D-93053 Regensburg, Germany.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

Conjugated enynes as well as cyclic nitronates are crucial building blocks for numerous natural products and pharmaceuticals. However, so far, no common and metal-free synthetic route to both conjugated enynes and cyclic nitronates has been reported. Herein, in situ NMR, labelling studies and theoretical calculations were combined to investigate the mechanism of the unusual triple bond formation towards conjugated enynes. Starting from nitroalkene dimers, first an isoxazolidine-2,5-diol derivative is formed as central intermediate. From this, enynes were generated by a combination of oxidation, dehydration, and retro 1,3-dipolar cycloaddition, whereas for nitronates a base induced intramolecular reorganization is proposed. While the product distribution could be controlled and high yields of nitronate were achieved, only medium to good yields for enynes were obtained due to polymerization losses. Nevertheless, we hope that these mechanistic investigations may provide a basis for further developments of organocatalytic or metal-free preparations of conjugated enynes and nitronates.

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Streitferdt, V; Haindl, MH; Hioe, J; Morana, F; Renzi, P; von Rekowski, F; Zimmermann, A; Nardi, M; Zeitler, K; Gschwind, RM or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents WOS:000480500600009 published article about ANTI-AIDS AGENTS; DITERPENOIDS; REPLICATION; ELIMINATION in [Liu, Qingbo; Li, Wei; Asada, Yoshihisa; Koike, Kazuo] Toho Univ, Fac Pharmaceut Sci, Miyama 2-2-1, Funabashi, Chiba 2748510, Japan; [Liu, Qingbo] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Lee, Kuo-Hsiung] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan; [Huang, Li; Chen, Chin-Ho] Duke Univ, Med Ctr, Dept Surg, Surg Sci, Durham, NC 27710 USA in 2019, Cited 21. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

Currently, due to the HIV latency mechanism, the search continues for effective drugs to combat this issue and provide a cure for AIDS. Gnidimacrin activates latent HIV-1 replication and inhibits HIV-1 infection at picomolar concentrations. This natural diterpene was able to markedly reduce the latent HIV-1 DNA level and the frequency of latently infected cells. Therefore, gnidimacrin is an excellent lead compound, and its anti-HIV potential merits further investigation. Twenty-nine modified gnidimacrin derivatives were synthesized and evaluated in assays for HIV replication and latency activation to establish which molecular structures must be maintained and which can tolerate changes that may be needed for better pharmacological properties. The results indicated that hydroxyl substituents at C-5 and C-20 are essential, while derivatives modified at 3-OH with aromatic esters retain anti-HIV replication and latent activation activities. The half-lives of the potent GM derivatives are over 20 h, which implies that they are stable in the plasm even though they contain ester linkages. The established structure activity relationship should be useful in the development of gnidimacrin or structurally related compounds as clinical trial candidates.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Liu, QB; Cheng, YY; Li, W; Huang, L; Asada, Y; Hsieh, MT; Morris-Natschke, SL; Chen, CH; Koike, K; Lee, KH or concate me.. HPLC of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 BIOORG MED CHEM LETT published article about PHARMACOLOGICAL EVALUATION; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ACCURATE DOCKING; OXAZOLIDINONE; OXADIAZOLES; DESIGN; GLIDE in [Kashid, Bharat B.; Salunkhe, Pravin H.; Dongare, Balasaheb B.; Ghanwat, Anil A.] Solapur Univ, Sch Chem Sci, Chem Res Lab, Solapur 413255, India; [Salunkhe, Pravin H.] CSIR Natl Chem Lab, Dr Homi Bhabha Rd, Pune 411008, Maharashtra, India; [More, Kishor R.] Shandong Keyuan Pharmaceut Co Ltd, Keyuan St, Jinan, Shandong, Peoples R China; [Khedkar, Vijay M.] Vishwakarma Univ, Sch Pharm, Survey 2,3,4 Laxminagar, Pune 411048, Maharashtra, India in 2020, Cited 43. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid

A series of novel 2, 5-disubstituted 1, 3, 4-Oxadiazole derivatives as a potential anti-inflammatory, and antioxidant agent were synthesized via cyclisation. Hydrazide molecule treated with substituted acids in the presence of phosphorus oxychloride (POCl3) as an efficient reagent as well as solvent by conventional method with shorter reaction time and excellent yield. The newly synthesized 1, 3, 4-oxadiazole derivatives exhibited excellent to good anti-inflammatory and anti-oxidant activities compaired to the standard drugs. Molecular docking study on the crucial anti-inflammatory target-cyclooxygenase-2 (COX-2) revealed the ability of the scaffold to correctly recognize the active site and achieve significant bonded and non-bonded interactions with key residues therein. This study could identify potential compounds which can be pertinent starting points for structure-based drug design to obtain newer anti-inflammatory agents.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Kashid, BB; Salunkhe, PH; Dongare, BB; More, KR; Khedkar, VM; Ghanwat, AA or concate me.. Safety of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Salimiyan, K; Saberi, D in [Salimiyan, Kimiya] Persian Gulf Univ, Fac Sci, Dept Chem, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Marine Chem Dept, Fac Marine Sci & Technol, Bushehr 75169, Iran; [Saberi, Dariush] Persian Gulf Univ, Fisheries & Aquaculture Dept, Fac Agr & Nat Resources, Bushehr 75169, Iran published Choline Chloride/Urea as an Eco-Friendly Deep Eutectic Solvent for TCT-Mediated Amide Coupling at Room Temperature in 2019, Cited 59. Quality Control of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A desirable alternative to organic solvents, very cheap, non-toxic and biodegradable deep eutectic solvent (DES) based on choline chloride and urea was introduced for 2,4,6-trichloro triazine mediated amide bond formation between carboxylic acids and amines at room temperature. Sub-stoichiometric amount of TCT was used as a cheap and readily available C-O activating reagent. Various derivatives of amines were coupled with carboxylic acids, via triacylated triazine intermediate, resulting the reaction of acids with TCT, and the corresponding amides were obtained in moderate to good yields.

Quality Control of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Salimiyan, K; Saberi, D or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

SDS of cas: 62-23-7. In 2020 ACS OMEGA published article about GOLD NANOPARTICLES; NITRO-COMPOUNDS; METAL NANOPARTICLES; HYDROGENATION; NITROBENZENE; OXIDATION; EFFICIENT; ALCOHOLS; ANILINE; PATHWAY in [Hong, Jee Eun; Jung, Yeonghun; Park, Youmie; Park, Yohan] Inje Univ, Coll Pharm, Gimhae 50834, Gyeongnam, South Korea; [Hong, Jee Eun; Jung, Yeonghun; Park, Youmie; Park, Yohan] Inje Univ, Inje Inst Pharmaceut Sci & Res, Gimhae 50834, Gyeongnam, South Korea in 2020, Cited 48. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A selective synthesis of hydrazoarene from nitroarene and its application are reported. Using polystyrene (PS) resins as solid supports for Au nanoparticles (AuNPs), polystyrene-supported Au nanoparticles (AuNPs@PS) were synthesized and characterized. In the presence of AuNPs@PS (1.0 mol %) as a catalyst, nitroarenes afforded corresponding hydrazoarenes (up to 99%) with high selectivity (up to 100%) under mild reaction conditions (NaBH4, 50% aq. EtOH, and room temperature). Depending on the reaction conditions (the amount of NaBH4, the substituent of nitroarenes, and the sequential addition of HCl), nitroarenes were converted to corresponding azoarenes (up to 95%), aminoarenes (up to 99%), and 4,4′-diaminobiaryls (up to 99%). Our easily recyclable catalytic system using a solid-phase reaction vessel provides an attractive synthetic method in an eco-friendly and sustainable manner.

SDS of cas: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hong, JE; Jung, Y; Park, Y; Park, Y or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. In 2020 RSC ADV published article about BETA-ENAMINO ESTERS; ENANTIOSELECTIVE REDUCTION; ASYMMETRIC HYDROSILYLATION; RATIONAL DESIGN; AMINES; PERSPECTIVE; DERIVATIVES; SELECTIVITY; AMIDATION; LIGANDS in [Massolo, Elisabetta; Pirola, Margherita; Puglisi, Alessandra; Rossi, Sergio; Benaglia, Maurizio] Univ Milan, Dipartimento Chim, Via Golgi 19, I-20133 Milan, Italy in 2020, Cited 42. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A two-step one pot, experimentally simple protocol, based on readily available and inexpensive reagents allowed the conversion of nitro-arenes directly to N-aryl amides. A metal-free reduction of the nitro group, mediated by trichlorosilane, followed by the addition of an anhydride afforded the corresponding N-aryl carboxyamide, that was isolated after a simple aqueous work up in good-excellent yields. When the methodology was applied to the reaction with gamma-butyrolactone, the desired N-aryl butanamide derivative was obtained, featuring a chlorine atom at the gamma-position, a functionalized handle that can be used for further synthetic manipulation of the reaction product. Such an intermediate has already been employed as a key advanced precursor of pharmaceutically active compounds.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Massolo, E; Pirola, M; Puglisi, A; Rossi, S; Benaglia, M or concate me.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Chemistry very interesting. Saw the article Designing of Ultrafine PdNPs Immobilized Pyridinic-N Doped Carbon and Evaluation of its Catalytic Potential for Konevenagel Condensation, Synthesis of 4H-pyran Derivatives and Nitroreduction published in 2019. Recommanded Product: 4-Nitrobenzoic acid, Reprint Addresses Gupta, M (corresponding author), Univ Jammu, Dept Chem, Jammu 180006, Jammu & Kashmir, India.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

We report the desiging of ultrafine Pd-based nanocatalyst containing N-doped carbon structure (Pd@NC). The material was prepared by direct dehydration at 120 degrees C followed by mixing and heating with a dopant (ammonium oxalate) at 150 degrees C in a furnace. The Pd@NC nanocatalyst containing electron-rich pyridinic-N doped carbon structure, was thoroughly characterized by various techniques namely SEM, EDX, TEM, FTIR, ICP-AES, XRD, XPS, TGA and Raman spectroscopy. The utility of the Pd@NC nanocatalyst was explored for base-free Knoevenagel condensation and 4H-pyran derivatives and also in the reduction of nitroarenes under mild and greener conditions. Further, the optical property was explored using photoluminescence spectroscopy and band gap was also calculated. The heterogeneous nature and stability of the catalyst facilitated by its ease of separation for long-term performance and recycling studies showed that catalyst was robust and remained active upto six recycling experiments. Also, the leaching of metal was confirmed by ICP-AES. The superiority of the catalyst was attributed to the metal support interaction (MSI) between metallic palladium and pyridinic-N doped carbon to acquire excellent catalytic activity and changing the reducing nature of NaBH4 towards nitro functionality. The MSI between pyridinic-N dopant on the carbon structure and PdNPs produces highly active sites for catalytic performance under mild conditions.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Chowhan, B; Gupta, M; Sharma, N or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Verbitskiy, EV; Rusinov, GL; Chupakhin, ON; Charushin, VN in ELSEVIER SCI LTD published article about INTRAMOLECULAR CHARGE-TRANSFER; PICRIC ACID; PHOTOPHYSICAL PROPERTIES; LUMINESCENT MATERIALS; SELECTIVE DETECTION; SENSITIVITY; DERIVATIVES; EFFICIENT; EMISSION; MOLECULE in [Verbitskiy, Egor V.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N.] Russian Acad Sci, I Postovsky Inst Organ Synth, Ural Branch, S Kovalevskaya Str 22, Ekaterinburg 620108, Russia; [Verbitskiy, Egor V.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N.] Ural Fed Univ, Mira St 19, Ekaterinburg 620002, Russia in 2020, Cited 98. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Highly sensitive and selective detection of nitro containing high energy organic compounds such as picric acid (PA), 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT) has become a challenging task due to concerns over national security, criminal investigations and environment protections. Among various known detection methods, fluorescence sensors have gained special attention in recent time. The family of fluorescent sensors based on push-pull systems that incorporate nitrogen heterocycles as an electron-withdrawing group have a growing interest due to their high sensitivity, selectivity and easy tuning. The fluorescent sensors discussed in this review are classified and organized according to used azahetemcyclic scaffold, their functionality and their ability to detect of nitmaromatics by fluorescence quenching.

SDS of cas: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Verbitskiy, EV; Rusinov, GL; Chupakhin, ON; Charushin, VN or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem