Month: October 2021

SDS of cas: 62-23-7. Lu, LX; Zhang, HY; Liu, J; Liu, Y; Wang, YW; Xu, ST; Zhu, ZY; Xu, JY in [Lu, Lixue; Zhang, Hengyuan; Liu, Yang; Wang, Yiwei; Xu, Shengtao; Xu, Jinyi] China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; [Lu, Lixue; Zhang, Hengyuan; Liu, Yang; Wang, Yiwei; Xu, Shengtao; Xu, Jinyi] China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; [Lu, Lixue; Liu, Jie] China Pharmaceut Univ, Dept Organ Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China; [Zhu, Zheying] Univ Nottingham, Sch Pharm, Div Mol Therapeut & Formulat, Univ Pk Campus, Nottingham NG7 2RD, England published Synthesis, biological evaluation and mechanism studies of C-23 modified 23-hydroxybetulinic acid derivatives as anticancer agents in 2019, Cited 18. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A series of C-23 modified 23-hydroxybetulinic acid (HBA) derivatives were synthesized and evaluated for their antiproliferative activity against a panel of cancer cell lines (A2780, A375, B16, MCF-7 and HepG2). The biological screening results showed that most of the derivatives exhibited more potent antiproliferative activity than HBA, and compound 6e exhibited the most potent activity with IC50 values of 2.14 mu M, 2.89 mu M, and 3.97 mu M against A2780, B16, and MCF-7 cells, respectively. Further anticancer mechanism studies revealed that compound 6e induced the generation of intracellular reactive oxygen species (ROS) and reduction of mitochondrial membrane potential (MMP) of B16 cells in a dose-dependent manner. Moreover, western blot analysis indicated that compound 6e downregulated the expression of anti-apoptotic protein Bcl-2 and upregulated the expression of proapoptotic protein Bax, activation of caspase 3 to induce cell apoptosis. Meanwhile, compound 6e significantly inhibited the phosphorylation of MEK, ERK, and Akt without affecting the expression of MEK, ERK, and Akt. Furthermore, the in vivo anti-tumor activity of 6e was validated (tumor inhibitory ratio of 68.4% at the dose of 30 mg/kg) in mice with B16 melanoma. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Lu, LX; Zhang, HY; Liu, J; Liu, Y; Wang, YW; Xu, ST; Zhu, ZY; Xu, JY or concate me.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. In 2020 J ORG CHEM published article about DIRECT ESTER CONDENSATION; LEWIS-ACID CATALYSTS; CARBOXYLIC-ACIDS; HOMOGENEOUS CATALYSIS; EFFICIENT CATALYSTS; ORGANIC-REACTIONS; MUKAIYAMA ALDOL; ALCOHOLS; WATER; HAFNIUM(IV) in [Villo, Piret; Dalla-Santa, Oscar; Szabo, Zoltan; Lundberg, Helena] KTH Royal Inst Technol, Sch Engn Sci Chem Biotechnol & Hlth, S-10044 Stockholm, Sweden in 2020, Cited 77. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

This work describes the use of kinetics as a tool for rational optimization of an esterification process with down to equimolar ratios of reagents using a recyclable commercially available zirconocene complex in catalytic amounts. In contrast to previously reported group IV metal-catalyzed esterification protocols, the work presented herein circumvents the use of water scavengers and perfluorooctane sulfonate (PFOS) ligands. Insights into the operating mechanism are presented.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Villo, P; Dalla-Santa, O; Szabo, Z; Lundberg, H or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 EUR J ORG CHEM published article about IN-SITU GENERATION; DIFLUOROMETHYL DIAZOMETHANE; TRIFLUOROMETHYL DIAZOMETHANE; 3+2 CYCLOADDITION; CARBOXYLIC-ACIDS; ETHOSUXIMIDE; DERIVATIVES; FLUORINE; CF3CHN2; 2,2,2-TRIFLUORODIAZOETHANE in [Gao, Yu; Peng, Shan-Qing; Liu, De-Yong; Rui, Pei-Xin; Hu, Xiang-Guo] Jiangxi Normal Univ, Natl Engn Res Ctr Carbohydrate Synth, Nanchang 330022, Jiangxi, Peoples R China; [Gao, Yu; Peng, Shan-Qing; Liu, De-Yong; Rui, Pei-Xin; Hu, Xiang-Guo] Jiangxi Normal Univ, Key Lab Small Funct Organ Mol, Minist Educ, Nanchang 330022, Jiangxi, Peoples R China in 2019, Cited 72. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

A general and efficient method for the synthesis N-difluoroethyl imides has been developed. This copper-catalyzed four-component reaction proceeds via in-situ generated difluorodiazomethane, which does not require prior formation and transferring. The reaction is scalable, tolerant toward a range of functional groups, and also suitable for the late-stage functionalization of drugs and drug-like molecules.

Recommanded Product: 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Gao, Y; Peng, SQ; Liu, DY; Rui, PX; Hu, XG or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Ma, QN; Yang, XD; Lei, XS; Lin, GQ in ROYAL SOC CHEMISTRY published article about ASYMMETRIC-SYNTHESIS; QUATERNARY CARBON; ALPHA(2C)-ADRENOCEPTOR ANTAGONIST; STEREOSELECTIVE CONSTRUCTION; REDUCTION; DELTA(3)-2-HYDROXYBAKUCHIOL; ACIDS in [Ma, Qiaoning; Lei, Xinsheng; Lin, Guo-Qiang] Fudan Univ, Inst Biomed Sci, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Ma, Qiaoning; Lei, Xinsheng; Lin, Guo-Qiang] Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Yang, Xiaodi; Lin, Guo-Qiang] Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, Shanghai 201203, Peoples R China; [Lin, Guo-Qiang] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Key Lab Synthet Chem Nat Subst, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019.0, Cited 32.0. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The preparation of ORM-10921, a selective (2C)-adrenoceptor antagonist with promising anti-psychotic properties, was successfully achieved using asymmetric -alkylation of ,-unsaturated imide and Bischler-Napieralski cyclization/asymmetric reduction as the key steps. When the tetracyclic iminium 11S was used in the reduction, the diastereo-selectivity was poor, from which four stereoisomers of ORM-10921 were obtained, respectively. However, the diastereoselectivity could be significantly improved (with dr up to >97:3) when the tricyclic imine substrate 19S was applied in this reduction, suggesting an additional chelation from the side-chain methoxy group in the transition state. According to this protocol, ORM-10921 was accomplished in a highly enantioselective manner. In addition, two analogs 26Aa and 26Ba were prepared using this novel method, and the absolute configurations were unambiguously assigned by single crystal X-ray crystallography.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Ma, QN; Yang, XD; Lei, XS; Lin, GQ or concate me.. SDS of cas: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about DIELS-ALDER REACTIONS; MANNICH-TYPE REACTION; ENANTIOSELECTIVE CONSTRUCTION; QUATERNARY; STEREOCENTERS; 2-OXINDOLES; SCAFFOLD; BEARING; DESIGN; JOINS, Saw an article supported by the Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry and Natural Science Foundation of Shanghai [16ZR1413800]. Recommanded Product: 4-Nitrobenzoic acid. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Cheng, WF; Chen, LY; Xu, FF; Lin, WY; Ren, XR; Li, Y. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

Organocatalytic asymmetric Michael addition between 3-substituted oxindoles and enals catalyzed by chiral camphor sulfonyl hydrazines (CaSHs) has been developed. A wide range of 3-substituted oxindoles and enals were successfully used, giving the corresponding 3,3-disubstituted oxindoles containing vicinal stereogenic carbon centers in good yields with good to excellent enantioselectivities and moderate to good diastereoselectivities (up to 89% yield, 99% ee and 99 : 1 dr).

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Cheng, WF; Chen, LY; Xu, FF; Lin, WY; Ren, XR; Li, Y or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019 ANTI-CANCER DRUG published article about INHIBITORS; DISCOVERY; POTENT; ANGIOGENESIS; SAR in [Huang, Yuanzheng; Zhang, Yang; Li, Jiaming; Ma, Xiaodong; Hu, Mengqi; Yang, Yu; Gao, Sufan] Anhui Acad Chinese Med, Sch Pharm, Dept Pharmaceut Chem, Hefei, Anhui, Peoples R China; [Li, Jiaming; Ma, Xiaodong] Anhui Acad Chinese Med, Dept Med Chem, Hefei, Anhui, Peoples R China in 2019, Cited 18. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. COA of Formula: C7H5NO4

A novel structural series of tetrahydroisoquinoline-based compounds that incorporate the diaryl urea moiety was designed, synthesized, and biologically evaluated as suppressors of VEFGR-2 signaling. As a consequence, compounds 9k and 9s exhibited comparable or superior cytotoxic activity to that of gefitinib against the tested three cell lines, including A549, MCF-7, and PC-3. Importantly, both of them downregulated the expression of VEGFR-2, and inhibited VEGFR-2 phosphorylation at the concentration of 0.5 or 1.0 mu mol/ l. Besides, they suppressed human umbilical vein endothelial cell tube formation at the concentration of 4.0 mu mol/ l. Considering their capability of down-regulating VEGFR-2 expression and inhibiting VEGFR-2 phosphorylation, 9k and 9s may serve as suppressors of angiogenesis for further investigation. Copyright (c) 2018 Wolters Kluwer Health, Inc. All rights reserved.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Huang, YZ; Zhang, Y; Li, JM; Ma, XD; Hu, MQ; Yang, Y; Gao, SF or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Ohtawa, M; Yano, K; Miyao, A; Hiura, T; Sugiyama, K; Arima, S; Kita, K; Omura, S; Nagamitsu, T in PERGAMON-ELSEVIER SCIENCE LTD published article about INHIBITORS; HARZIANOPYRIDONE; NBRI23477; MECHANISM; POTENT in [Ohtawa, Masaki; Yano, Keisuke; Miyao, Atsuyoshi; Hiura, Tohru; Sugiyama, Kouhei; Arima, Shiho; Nagamitsu, Tohru] Kitasato Univ, Sch Pharm, Dept Synthet Nat Prod Chem, Minato Ku, 5-9-1 Shirokane, Tokyo 1088641, Japan; [Ohtawa, Masaki; Yano, Keisuke; Miyao, Atsuyoshi; Hiura, Tohru; Sugiyama, Kouhei; Arima, Shiho; Nagamitsu, Tohru] Kitasato Univ, Sch Pharm, Med Res Labs, Minato Ku, 5-9-1 Shirokane, Tokyo 1088641, Japan; [Kita, Kiyoshi] Nagasaki Univ, Sch Trop Med & Global Hlth, Nagasaki 1088641, Japan; [Omura, Satoshi] Kitasato Univ, Kitasato Inst Life Sci, Tokyo 1088641, Japan in 2019.0, Cited 18.0. HPLC of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

We designed and synthesized new atpenin A5 analogs for SAR study. Most of the analogs lacked one or several functional groups in the side chain of atpenin A5, and the stereoisomers proved to be weak nematode complex 11 inhibitors. However, we determined that 4-epi-atpenin A5 was a potent nematode complex II inhibitor comparable to atpenin A5. Therefore, 4-epi-atpenin A5 is expected to become a new lead compound in nematicide development. (C) 2019 Elsevier Ltd. All rights reserved.

HPLC of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Ohtawa, M; Yano, K; Miyao, A; Hiura, T; Sugiyama, K; Arima, S; Kita, K; Omura, S; Nagamitsu, T or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Category: phthalazines. In 2020 ADV SYNTH CATAL published article about H BOND ACETOXYLATION; HYPERVALENT IODINE(III); NENITZESCU REACTION; C(SP(3))-H; MECHANISM; HETEROCYCLES; IMPACT; ACID in [Jeyakannu, Palaniraja; Chiang, Chun-Hsien; Kumar Dhandabani, Ganesh; Chang, Yu-Ching; Wang, Jeh-Jeng] Kaohsiung Med Univ, Dept Med & Appl Chem, 100 Shih Chuan 1st Rd, Kaohsiung 807, Taiwan; [Chandru Senadi, Gopal] SRM Inst Sci & Technol, Fac Engn & Technol, Dept Chem, Chennai 603203, Tamil Nadu, India; [Wang, Jeh-Jeng] Kaohsiung Med Univ Hosp, Dept Med Res, 100 Tzyou 1st Rd, Kaohsiung 807, Taiwan in 2020, Cited 67. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Versatile role of lambda(3)-iodanes has been identified between the reaction of hydroquinone and beta-enaminones for the synthesis of 5-acyloxy-4-hydroxy indoles. The reaction is proposed to proceed through an intermolecular C-C bond formation, intramolecular cyclization, acyloxylation and 1,4-acyl migration. The important features of this work include various acyloxylation from lambda(3)-iodanes and broad functional group tolerance to deliver 34 examples in moderate to good yields.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Jeyakannu, P; Senadi, GC; Chiang, CH; Dhandabani, GK; Chang, YC; Wang, JJ or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Janetka, JW; Hopper, AT; Yang, ZP; Barks, J; Dhason, MS; Wang, QL; Sibley, LD in AMER CHEMICAL SOC published article about SELECTIVE-INHIBITION; GONDII; IDENTIFICATION; TRANSMISSION; ENCEPHALITIS; MECHANISM; DIAGNOSIS; INVASION; THERAPY; STRAINS in [Janetka, James W.] Washington Univ, Sch Med, Dept Biochem & Mol Biophys, St Louis, MO 63110 USA; [Barks, Jennifer; Dhason, Mary Savari; Wang, Qiuling; Sibley, L. David] Washington Univ, Sch Med, Dept Mol Microbiol, St Louis, MO 63110 USA; [Hopper, Allen T.; Yang, Ziping] Vyera Pharmaceut, New York, NY 10016 USA in 2020, Cited 56. Recommanded Product: 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Calcium dependent protein kinase 1 (CDPK1) is an essential Ser/Thr kinase that controls invasion and egress by the protozoan parasite Toxoplasma gondii. The Gly gatekeeper of CDPK1 makes it exquisitely sensitive to inhibition by small molecule 1H-pyrazolo[3,4-d]pyrimidine-4-amine (PP) compounds that are bulky ATP mimetics. Here we rationally designed, synthesized, and tested a series of novel PP analogs that were evaluated for inhibition of CDPK1 enzyme activity in vitro and parasite growth in cell culture. Optimal substitution on the PP scaffold included 2-pyridyl ethers directed into the hydrophobic pocket and small carbocyclic rings accessing the ribose-binding pocket. Further optimization of the series led to identification of the lead compound 3a that displayed excellent potency, selectivity, safety profile, and efficacy in vivo. The results of these studies provide a foundation for further work to optimize CDPK1 inhibitors for the treatment of acute and chronic toxoplasmosis.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Janetka, JW; Hopper, AT; Yang, ZP; Barks, J; Dhason, MS; Wang, QL; Sibley, LD or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 CHEM ENG J published article about PERSONAL CARE PRODUCTS; GRAPHITIC CARBON NITRIDE; WATER TREATMENT PLANTS; ELECTRONIC-STRUCTURE; HYDROGEN EVOLUTION; PHARMACEUTICALS; PERFORMANCE; CHARGE; HETEROJUNCTION; G-C3N4 in [Jiang, Runren; Lu, Guanghua; Yan, Zhenhua; Wu, Donghai; Zhou, Ranran; Bao, Xuhui] Hohai Univ, Coll Environm, Minist Educ, Key Lab Integrated Regulat & Resources Dev Shallo, Nanjing 210098, Jiangsu, Peoples R China; [Lu, Guanghua] Tibet Agr & Anim Husb Univ, Water Conservancy Project, Linzhi 860000, Peoples R China; [Lu, Guanghua] Tibet Agr & Anim Husb Univ, Civil Engn Coll, Linzhi 860000, Peoples R China in 2019.0, Cited 50.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Safety of 4-Nitrobenzoic acid

The development of a novel Z-scheme system with a high separation efficiency of the charge carriers for remarkably enhanced photocatalytic activity is highly desirable. Herein, a carbon quantum dot-modified SnNb2O6/BiOCl (CQD-SNO/BOC) Z-scheme system, in which the CQDs acted as a bridge for the charge carriers, was successfully synthesized. As expected, the CQDs acted as a bridge for the charge carriers that could separate and accumulate electrons from SnNb2O6 and holes from BiOCl by promoting the transfer of the photoinduced charge carriers, which enabled the BiOCl holes to maintain their high oxidation capability. Additionally, the CQDs not only endowed the SNO/BOC Z-scheme system with a large specific surface area that provided a greater number of active sites but also noticeably improved its visible light absorption capacity. Therefore, the CQDSNO/BOC Z-scheme system showed an improved photocatalytic performance for the degradation of benzocaine (BC), which was over 20 times, 10 times and 2 times greater than those of BiOCl, SnNb2O6 and SNO/BOC Z-scheme systems, respectively. In addition, the effects of catalyst concentration, pH value, different anions, and humic acid (HA) concentration on the photodegradation of BC were investigated in depth. Simultaneously, a four-stage pathway for the degradation of BC was proposed based on the degradation products that were identified, and the accuracy of this pathway was further verified based on biotoxicity assessments and toxicity predictions of the products. According to the ESR spectra and active species trapping experiments, a mechanism for the CQD-SNO/BOC Z-scheme system was proposed, in which the CQD bridge accelerated charge transfer. Based on these results, the CQD-modified Z-scheme system could be an efficient and promising photocatalyst for the degradation of PPCPs in water.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Jiang, RR; Lu, GH; Yan, ZH; Wu, DH; Zhou, RR; Bao, XH or concate me.. Safety of 4-Nitrobenzoic acid

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem