Month: October 2021

Product Details of 62-23-7. I found the field of Chemistry very interesting. Saw the article Dynamic Carbon Isotope Exchange of Pharmaceuticals with Labeled CO2 published in 2019.0, Reprint Addresses Audisio, D (corresponding author), Univ Paris Saclay, CEA, DRF, SCBM,JOLIOT, F-91191 Gif Sur Yvette, France.; Cantat, T (corresponding author), Univ Paris Saclay, CNRS, CEA, NIMBE, F-91191 Gif Sur Yvette, France.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

A copper-catalyzed procedure enabling dynamic carbon isotope exchange is described. Utilizing the universal precursor [C-14]CO2, this protocol allows to insert, in one single step, the desired carbon tag into carboxylic acids with no need of structural modifications. Reducing synthetic costs and limiting the generation of radioactive waste, this procedure will facilitate the access to carboxylic acids containing drugs and accelerate early C-14-based ADME studies supporting drug development.

Product Details of 62-23-7. About 4-Nitrobenzoic acid, If you have any questions, you can contact Destro, G; Loreau, O; Marcon, E; Taran, F; Cantat, T; Audisio, D or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

COA of Formula: C7H5NO4. Liu, QB; Cheng, YY; Li, W; Huang, L; Asada, Y; Hsieh, MT; Morris-Natschke, SL; Chen, CH; Koike, K; Lee, KH in [Liu, Qingbo; Li, Wei; Asada, Yoshihisa; Koike, Kazuo] Toho Univ, Fac Pharmaceut Sci, Miyama 2-2-1, Funabashi, Chiba 2748510, Japan; [Liu, Qingbo] Shenyang Pharmaceut Univ, Minist Educ, Key Lab Struct Based Drug Design & Discovery, Shenyang 110016, Liaoning, Peoples R China; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Morris-Natschke, Susan L.; Lee, Kuo-Hsiung] Univ N Carolina, UNC Eshelman Sch Pharm, Nat Prod Res Labs, Chapel Hill, NC 27599 USA; [Cheng, Yung-Yi; Hsieh, Min-Tsang; Lee, Kuo-Hsiung] China Med Univ & Hosp, Chinese Med Res & Dev Ctr, Taichung 40402, Taiwan; [Huang, Li; Chen, Chin-Ho] Duke Univ, Med Ctr, Dept Surg, Surg Sci, Durham, NC 27710 USA published Synthesis and Structure-Activity Relationship Correlations of Gnidimacrin Derivatives as Potent HIV-1 Inhibitors and HIV Latency Reversing Agents in 2019, Cited 21. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Currently, due to the HIV latency mechanism, the search continues for effective drugs to combat this issue and provide a cure for AIDS. Gnidimacrin activates latent HIV-1 replication and inhibits HIV-1 infection at picomolar concentrations. This natural diterpene was able to markedly reduce the latent HIV-1 DNA level and the frequency of latently infected cells. Therefore, gnidimacrin is an excellent lead compound, and its anti-HIV potential merits further investigation. Twenty-nine modified gnidimacrin derivatives were synthesized and evaluated in assays for HIV replication and latency activation to establish which molecular structures must be maintained and which can tolerate changes that may be needed for better pharmacological properties. The results indicated that hydroxyl substituents at C-5 and C-20 are essential, while derivatives modified at 3-OH with aromatic esters retain anti-HIV replication and latent activation activities. The half-lives of the potent GM derivatives are over 20 h, which implies that they are stable in the plasm even though they contain ester linkages. The established structure activity relationship should be useful in the development of gnidimacrin or structurally related compounds as clinical trial candidates.

COA of Formula: C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Liu, QB; Cheng, YY; Li, W; Huang, L; Asada, Y; Hsieh, MT; Morris-Natschke, SL; Chen, CH; Koike, K; Lee, KH or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4-Nitrobenzoic acid. In 2019 MOLECULES published article about STANDARD MOLAR ENTHALPY; STRUCTURE-PROPERTY RELATIONSHIPS; THERMODYNAMIC PROPERTIES; IONIC LIQUIDS; THERMOPHYSICAL PROPERTIES; TEMPERATURE-RANGE; GROUP ADDITIVITY; VAPOR-PRESSURES; THERMAL-ANALYSIS; COMPUTATIONAL THERMOCHEMISTRY in [Naef, Rudolf] Univ Basel, Dept Chem, CH-4003 Basel, Switzerland in 2019, Cited 287. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A universally applicable method for the prediction of the isobaric heat capacities of the liquid and solid phase of molecules at 298.15 K is presented, derived from their true volume. The molecules’ true volume in A(3) is calculated on the basis of their geometry-optimized structure and the Van-der-Waals radii of their constituting atoms by means of a fast numerical algorithm. Good linear correlations of the true volume of a large number of compounds encompassing all classes and sizes with their experimental liquid and solid heat capacities over a large range have been found, although noticeably distorted by intermolecular hydrogen-bond effects. To account for these effects, the total amount of 1303 compounds with known experimental liquid heat capacities has been subdivided into three subsets consisting of 1102 hydroxy-group-free compounds, 164 monoalcohols/monoacids, and 36 polyalcohols/polyacids. The standard deviations for Cp(liq,298) were 20.7 J/mol/K for the OH-free compunds, 22.91 J/mol/K for the monoalcohols/monoacids and 16.03 J/mol/K for the polyols/polyacids. Analogously, 797 compounds with known solid heat capacities have been separated into a subset of 555 OH-free compounds, 123 monoalcohols/monoacids and 119 polyols/polyacids. The standard deviations for Cp(sol,298) were calculated to 23.14 J/mol/K for the first, 21.62 J/mol/K for the second, and 19.75 J/mol/K for the last subset. A discussion of structural and intermolecular effects influencing the heat capacities as well as of some special classes, in particular hydrocarbons, ionic liquids, siloxanes and metallocenes, has been given. In addition, the present method has successfully been extended to enable the prediction of the temperature dependence of the solid and liquid heat capacities in the range between 250 and 350 K.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Naef, R or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Bertrand, X; Paquin, JF in [Bertrand, Xavier; Paquin, Jean-Francois] Univ Laval, Dept Chim, PROTEO, CCVC, 1045 Ave Med, Quebec City, PQ G1V 0A6, Canada published Direct Hydrofluorination of Methallyl Alkenes Using a Methanesulfonic Acid/Triethylamine Trihydrofluoride Combination in 2019.0, Cited 27.0. Category: phthalazines. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The use of a methanesulfonic acid/triethylamine trihydrofluoride combination for the direct hydrofluorination of methallyl-containing substrates is reported. Under those metal-free conditions that use readily available, cheap, and easy to handle reagents, a range of methallyl alkenes could be converted to their corresponding tertiary fluoride in up to 78% yield. Finally, a promising result for the adaptation of this chemistry to continuous flow conditions is reported.

Category: phthalazines. About 4-Nitrobenzoic acid, If you have any questions, you can contact Bertrand, X; Paquin, JF or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Novel 1,3,4-oxadiazoles as antitubercular agents with limited activity against drug-resistant tuberculosis WOS:000472715700003 published article about MYCOBACTERIUM-TUBERCULOSIS; CLINICAL CANDIDATE; DERIVATIVES; DISCOVERY; PYRIDINE; Q203 in [Makane, Vitthal B.; Rode, Haridas B.] CSIR Indian Inst Chem Technol, Dept Organ Synth & Proc Chem, Hyderabad 500007, Telangana, India; [Makane, Vitthal B.; Krishna, Eruva Vamshi; Misra, Sunil; Rode, Haridas B.] Acad Sci & Innovat Res, Ghaziabad 201002, Uttar Pradesh, India; [Krishna, Vagolu Siva; Sriram, Dharmarajan] Birla Inst Technol & Sci Pilani, Dept Pharm, Hyderabad Campus, Hyderabad 500078, Telangana, India; [Krishna, Eruva Vamshi; Misra, Sunil] CSIR Indian Inst Chem Technol, Dept Biol, Hyderabad 500007, Telangana, India; [Shukla, Manjulika; Chopra, Sidharth] CSIR Cent Drug Res Inst, Dept Microbiol, Lucknow 226021, Uttar Pradesh, India; [Mahizhaveni, Balakrishnan; Dusthackeer, Vijayan N. Azger] Natl Inst Res TB, Dept Bacteriol, Chennai, Tamil Nadu, India in 2019, Cited 25. Safety of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

Aim: In recent times, heterocyclic chemotypes are being explored for the development of new antimycobacterials that target the drug-resistant tuberculosis. Here, we are disclosing the 5-substitued 2-mercapto-1,3,4-oxadiazoles as potent antitubercular agents. Methodology: A small library of 2-mercapto-1,3,4-oxadiazoles was synthesized using various acids. The compounds were evaluated for antituberculosis activity against M. tuberculosis H37Rv. Results: Compound 8j was identified as antitubercular lead with MIC of 0.6g/ml against M. tuberculosis H37Rv. This compound was nontoxic to CHO-K1 cells and showed selectivity index of 39. Of note, 8j showed antitubercular activity against pre-extensively drug-resistant clinical isolate of Mycobacterium with MIC of 2g/ml. Conclusion: This study provides potent antitubercular agent which can be further optimized to discover novel antibiotics. [GRAPHICS] .

Safety of 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Makane, VB; Krishna, VS; Krishna, EV; Shukla, M; Mahizhaveni, B; Misra, S; Chopra, S; Sriram, D; Dusthackeer, VNA; Rode, HB or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Computed Properties of C7H5NO4. Recently I am researching about GOLD NANOPARTICLES; NITRO-COMPOUNDS; METAL NANOPARTICLES; HYDROGENATION; NITROBENZENE; OXIDATION; EFFICIENT; ALCOHOLS; ANILINE; PATHWAY, Saw an article supported by the Basic Science Research Program through the National Research Foundation of Korea (NRF) – Ministry of Education, Republic of Korea [NRF-2016R1D1A1B04930774]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Hong, JE; Jung, Y; Park, Y; Park, Y. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A selective synthesis of hydrazoarene from nitroarene and its application are reported. Using polystyrene (PS) resins as solid supports for Au nanoparticles (AuNPs), polystyrene-supported Au nanoparticles (AuNPs@PS) were synthesized and characterized. In the presence of AuNPs@PS (1.0 mol %) as a catalyst, nitroarenes afforded corresponding hydrazoarenes (up to 99%) with high selectivity (up to 100%) under mild reaction conditions (NaBH4, 50% aq. EtOH, and room temperature). Depending on the reaction conditions (the amount of NaBH4, the substituent of nitroarenes, and the sequential addition of HCl), nitroarenes were converted to corresponding azoarenes (up to 95%), aminoarenes (up to 99%), and 4,4′-diaminobiaryls (up to 99%). Our easily recyclable catalytic system using a solid-phase reaction vessel provides an attractive synthetic method in an eco-friendly and sustainable manner.

Computed Properties of C7H5NO4. About 4-Nitrobenzoic acid, If you have any questions, you can contact Hong, JE; Jung, Y; Park, Y; Park, Y or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Xu, ZF; An, YH; Chen, YD; Duan, SG in [Xu, Ze-Feng; An, Yuehui; Chen, Yidian; Duan, Shengguo] Zhejiang Sci Tech Univ, Dept Chem, Hangzhou 310018, Peoples R China; [Xu, Ze-Feng] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Rd, Shanghai 200032, Peoples R China published Rhodium-catalysed synthesis of fused pyrimidine derivatives employing N-sulfonyl-1,2,3-triazoles as a 1-aza-[4C] synthon in 2019, Cited 59. Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A new synthetic application of N-sulfonyl-1,2,3-triazoles acting as a 1-aza-[4C] synthon via the 1,2-shift reaction of an alpha-imine rhodium carbene was developed for the synthesis of fused pyrimidine derivatives. The high reactivity of the strained three-membered 2H-azirine ring facilitated the unusual cyclization of electron-deficient dienes with electron-deficient dienophiles. The compatibility was good with common functionalities tolerated. Excellent chemoselectivity was observed, and no reactions occurred between the rhodium carbene and 2H-azirine. The products could be converted into seven-membered multi-functionalized 1H-1,4-diazepine derivatives, illustrating the potential application of the protocol in medium-sized N-heterocycle synthesis. (C) 2019 Elsevier Ltd. All rights reserved.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Xu, ZF; An, YH; Chen, YD; Duan, SG or concate me.. Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recommanded Product: 4-Nitrobenzoic acid. I found the field of Chemistry very interesting. Saw the article Metal-Free Synthesis of Indolopyrans and 2,3-Dihydrofurans Based on Tandem Oxidative Cycloaddition published in 2020.0, Reprint Addresses Park, CM (corresponding author), UNIST Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid.

The synthesis of versatile scaffold indolopyrans based on C-C radical-radical cross-coupling under metal-free conditions is described. The reaction involving single electron transfer between coupling partners followed by cage collapse allows highly selective cross-coupling while employing only equimolar amounts of coupling partners. Moreover, the mechanistic manifold was expanded for the functionalization of enamines to give the stereoselective synthesis of 2,3-dihydrofurans. This iodine-mediated oxidative coupling features mild conditions and fast reaction kinetics.

Recommanded Product: 4-Nitrobenzoic acid. About 4-Nitrobenzoic acid, If you have any questions, you can contact Choi, S; Oh, H; Sim, J; Yu, E; Shin, S; Park, CM or concate me.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Design of fluorescent sensors based on azaheterocyclic push-pull systems towards nitroaromatic explosives and related compounds: A review WOS:000541131700064 published article about INTRAMOLECULAR CHARGE-TRANSFER; PICRIC ACID; PHOTOPHYSICAL PROPERTIES; LUMINESCENT MATERIALS; SELECTIVE DETECTION; SENSITIVITY; DERIVATIVES; EFFICIENT; EMISSION; MOLECULE in [Verbitskiy, Egor V.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N.] Russian Acad Sci, I Postovsky Inst Organ Synth, Ural Branch, S Kovalevskaya Str 22, Ekaterinburg 620108, Russia; [Verbitskiy, Egor V.; Rusinov, Gennady L.; Chupakhin, Oleg N.; Charushin, Valery N.] Ural Fed Univ, Mira St 19, Ekaterinburg 620002, Russia in 2020, Cited 98. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

Highly sensitive and selective detection of nitro containing high energy organic compounds such as picric acid (PA), 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT) has become a challenging task due to concerns over national security, criminal investigations and environment protections. Among various known detection methods, fluorescence sensors have gained special attention in recent time. The family of fluorescent sensors based on push-pull systems that incorporate nitrogen heterocycles as an electron-withdrawing group have a growing interest due to their high sensitivity, selectivity and easy tuning. The fluorescent sensors discussed in this review are classified and organized according to used azahetemcyclic scaffold, their functionality and their ability to detect of nitmaromatics by fluorescence quenching.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about STYRYL-LACTONES, Saw an article supported by the University Grants Commission (UGC), New DelhiUniversity Grants Commission, India; Council of Scientific and Industrial Research (CSIR), New DelhiCouncil of Scientific & Industrial Research (CSIR) – India. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Kotammagari, TK; Paul, S; Bhattacharya, AK. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. HPLC of Formula: C7H5NO4

(-)-5-Hydroxygoniothalamin, (-)-5-acetylgoniothalamin, and (+)-5-hydroxygoniothalamin, isolated from the Goniothalamus genus, are synthesized from triacetyl-O-D-glucal by employing the Ferrier reaction, Mitsunobu reaction, and Jones oxidation as key steps. The synthetic procedure also yields the epimers of (-)-5-hydroxygoniothalamin and (+)-5-hydroxygoniothalamin employing acid-mediated transition-metal-free epimerization at C-5 of styryllactones. Further studies reveal that the epimerization is facilitated by the phenyl group present on the styryllactones. Also, depending on the dihydroxylation reaction conditions, various analogues of saturated styryllactones are synthesized utilizing oxa-Michael reaction conditions.

About 4-Nitrobenzoic acid, If you have any questions, you can contact Kotammagari, TK; Paul, S; Bhattacharya, AK or concate me.. HPLC of Formula: C7H5NO4

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem