An article Design, synthesis and evaluation of halogenated furanone derivatives as quorum sensing inhibitors in Pseudomonas aeruginosa WOS:000493896400004 published article about 1,2-ALLENYL CARBOXYLIC-ACIDS; SUPPORTED ARYL IODIDES; BIOFILM FORMATION; CYCLIZATION REACTION; IDENTIFICATION; GENERATION; COMPLEXES; SYSTEM in [Chang, Yiqun; Wang, Peng-Cheng; Chen, Si-Yu; Fu, Yu-Hang; Liu, Yuan-Yuan; Wang, Xuan; Zhou, Hai-Bo; Chen, Wei-Min; Lin, Jing; Sun, Ping-Hua] Jinan Univ, Coll Pharm, Int Cooperat Lab Tradit Chinese Med Modernizat &, Chinese Minist Educ, Guangzhou 510632, Guangdong, Peoples R China; [Chang, Yiqun; Hibbs, David E.] Univ Sydney, Fac Med & Hlth, Sydney, NSW 2006, Australia; [Ma, Hong-Ming; Yu, Guang-Chao] Jinan Univ, Affiliated Hosp 1, Dept Resp, Guangzhou 510632, Guangdong, Peoples R China; [Huang, Tao; Zheng, Jun-Xia] Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Guangdong, Peoples R China; [Wang, Chao] Yale Univ, Dept Chem, 225 Prospect St, New Haven, CT 06520 USA in 2019, Cited 43. Safety of 4-Nitrobenzoic acid. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7
The biofilm formation of Pseudomonas aeruginosa (P. aeruginosa) is regulated by a phenomenon of quorum sensing (QS). With 5-hydroxyl-3,4-halogenated-5H-furan-2-ones as beginning, analogs bearing alkyl chains, vinyl bromide, or aromatic rings were designed and synthesized. The minimum inhibitory concentration (MIC) of the compounds against P. aeruginosa was assayed and the biofilm inhibition ratio was determined at different concentrations lower than the MIC. C-5 aromatic substituted furanones showed remarkable biofilm formation as well as inhibition of virulence factor production in P. aeruginosa. Fluorescence report analysis identified the QS regulatory mechanism of the most active compound 29. This study provides us a novel candidate for combating drug resistant bacteria strains by merely inhibiting biofilm formation. Without suppressing the regular life cycle of the bacteria, bacterial resistance mechanisms may not be activated.
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Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem