An article Synthesis of N-Substituted Benzamide Derivatives and their Evaluation as Antitumor Agents WOS:000536018300009 published article about HISTONE DEACETYLASE INHIBITORS; DESIGN in [Chen, Taiping; Jiang, Hongwu; Zhou, Jianjun; Li, Zicheng; Huang, Wencai] Sichuan Univ, Sch Chem Engn, Chengdu 610065, Sichuan, Peoples R China; [Luo, Youfu; Zhao, Yinglan] West China Hosp, West China Med Sch, State Key Lab Biotherapy, Chengdu 610041, Sichuan, Peoples R China in 2020.0, Cited 14.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Computed Properties of C7H5NO4
Background: Histone deacetylases inhibitors (HDACIs) with different chemical structures have been reported to play an important role in the treatment of cancer. Objective: The study aims to modify the structure of Entinostat (MS-275) to discover new compounds with improved anti-proliferative activities and perform SAR studies on this class of bioactive compounds. Methods: Fourteen N-substituted benzamide derivatives were synthesized and their antiproliferative activities were tested with four cancer cell lines (MCF-7, A549, K562 and MDA-MB-231) by MTT assay. Results: Compared with MS-275, six compounds exhibited comparable or even better anti-proliferative activities against specific/certain cancer cell lines. Conclusion: The preliminary SARs showed that (i) the 2-substituent of the phenyl ring in the R group and heteroatoms of amide which can chelate with zinc ion are critical to the anti-proliferative activity and (ii) chlorine atom or nitro-group on the same benzene ring largely decreases their anti-proliferative activity. Molecular docking study illustrated the interaction (binding affinity) between the synthesized compounds and HDAC2 was observed to be similar to that of MS-275.
Computed Properties of C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem