Month: November 2021

Product Details of 62-23-7. Nakamura, D; Sasano, Y; Iwabuchi, Y in [Nakamura, Daichi; Sasano, Yusuke; Iwabuchi, Yoshiharu] Tohoku Univ, Grad Sch Pharmaceut Sci, Sendai, Miyagi, Japan published Ln(OTf)(3)-catalysed highly regioselective alcoholysis of 2,3-epoxy alcohols in 2019.0, Cited 47.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

Regioselectivity of Ln(OTf)(3)-catalysed alcoholysis of 2,3- and 3,4-epoxy alcohols was closely investigated to expand the scope of the transformations. The synthetic use was demonstrated by application to the construction of 4-propoxy-5-hydroxy-2,3-pentanedione (C4-propoxy-HPD), which is a potent synthetic mediator in AI-2 quorum sensing.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. Xiong, J; Wei, X; Wan, YC; Ding, MW in [Xiong, Jun; Wei, Xiao; Wan, Yu-Chen; Ding, Ming-Wu] Cent China Normal Univ, Key Lab Pesticide & Chem Biol, Minist Educ, Hubei Int Sci & Technol Cooperat Base Pesticide &, Wuhan, Hubei, Peoples R China; [Xiong, Jun] Hubei Univ Sci & Technol, Coll Pharm, Xianning 437100, Hubei, Peoples R China published One-pot and regioselective synthesis of polysubstituted 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by sequential Ugi/Staudinger/aza-Wittig reaction in 2019.0, Cited 59.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

An efficient one-pot and regioselective synthesis of 3,4-dihydroquinazolines and 4,5-dihydro-3H-1,4-benzodiazepin-3-ones by Ugi/Staudinger/aza-Wittig sequence has been developed. The Ugi reactions of 2-azidobenzylamines, aldehydes, acids (or alpha-keto acids) and isocyanides produced the azide intermediates, which were then treated with tributylphosphine or triphenylphosphine to give poly-substituted 3,4-dihydroquinazolines or 4,5-dihydro-3H-1,4-benzodiazepin-3-ones in moderate to good yields by tandem Standinger/aza-Wittig reactions. (C) 2019 Elsevier Ltd. All rights reserved.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Xiong, J; Wei, X; Wan, YC; Ding, MW or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020 J MED CHEM published article about AUREUS STRESS TOLERANCE; STAPHYLOCOCCUS-AUREUS; PROTEASE; INSIGHTS; CLEAVAGE; REVEAL; ROLES in [Ju, Yuan; He, Lihui; Zhou, Yuanzheng; Yang, Tao; Sun, Ke; Song, Rao; Yang, Yang; Li, Chengwei; Bao, Rui; Luo, Youfu] Sichuan Univ, State Key Lab Biotherapy, Collaborat Innovat Ctr Biotherapy, West China Hosp, Chengdu 610041, Peoples R China; [Ju, Yuan; He, Lihui; Zhou, Yuanzheng; Yang, Tao; Sun, Ke; Song, Rao; Yang, Yang; Li, Chengwei; Bao, Rui; Luo, Youfu] Sichuan Univ, Canc Ctr, Collaborat Innovat Ctr Biotherapy, West China Hosp, Chengdu 610041, Peoples R China; [Sang, Zitai] Luoyang Normal Univ, Inst Life Sci, Luoyang 471934, Henan, Peoples R China in 2020, Cited 53. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

Caseinolytic protease P (ClpP) is considered as a promising target for the treatment of Staphylococcus aureus infections. In an unbiased screen of 2632 molecules, a peptidomimetic boronate, MLN9708, was found to be a potent suppressor of SaClpP function. A time-saving and cost-efficient strategy integrating in silico position scanning, multistep miniaturized synthesis, and bioactivity testing was deployed for optimization of this hit compound and led to fast exploration of structure-activity relationships. Five of 150 compounds from the miniaturized synthesis exhibited improved inhibitory activity. Compound 43Hf was the most active inhibitor and showed reversible covalent binding to SaClpP while did not destabilize the tetradecameric structure of SaClpP. The crystal structure of 43Hf-SaClpP complex provided mechanistic insight into the covalent binding mode of peptidomimetic boronate and SaClpP. Furthermore, 43Hf could bind endogenous ClpP in S. aureus cells and exhibited significant efficacy in attenuating S. aureus virulence in vitro and in vivo.

Quality Control of 4-Nitrobenzoic acid. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Design, synthesis and anti-influenza A virus activity of novel 2,4-disubstituted quinazoline derivatives WOS:000526087400006 published article about INFLUENZA-A; INHIBITORS; DISCOVERY in [Wang, Minghua; Zhang, Guoning; Wang, Yujia; Wang, Juxian; Zhu, Mei; Cen, Shan; Wang, Yucheng] Chinese Acad Med Sci & Peking Union Med Coll, Inst Med Biotechnol, Beijing 100050, Peoples R China in 2020, Cited 28. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Recommanded Product: 62-23-7

Four 2,4-disubstituted quinazoline series containing various amide moieties were designed and synthesized as new anti-influenza A virus agents using the strategies of bio-isosterism and scaffold hopping. Many of them exhibit potent in vitro anti-influenza A virus activity and low cytotoxicity (CC50: > 100 mu M). Particularly, compounds 10a5 and 17a show better activity (IC50: 3.70-4.19 mu M) and higher selective index (SI: > 27.03, > 23.87, respectively) against influenza A/WSN/33 virus (H1N1), opening a new direction for quinazoline derivatives in anti-influenza A virus field.

Welcome to talk about 62-23-7, If you have any questions, you can contact Wang, MH; Zhang, GN; Wang, YJ; Wang, JX; Zhu, M; Cen, S; Wang, YC or send Email.. Recommanded Product: 62-23-7

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about ORGANOSELENIUM COMPOUNDS; ELECTROCHEMICAL OXYSELENENYLATION; ANTIOXIDANT ACTIVITY; OLEFINS; OXIDATION; SELENIUM; ALKENES; CHEMISTRY; ACETOXYSELENENYLATION; FUNCTIONALIZATION, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21902014]; Basic and Frontier Research Project of Chongqing [Cstc2018jcyjAX0051, Cstc2016jcyjA0056]. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Chen, JY; Chen, R; Mei, L; Yan, SS; Wu, Y; Li, Q; Yuan, BF. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. Safety of 4-Nitrobenzoic acid

An efficient and green protocol for synthesizing beta-acyloxyselenides was developed through the visible-light-induced difunctionalization of styrenes with a binary system of diaryldiselenides and carboxylic acids under mild reaction conditions, without using any transition-metal-catalysts. This protocol is scalable and tolerates a wide spectrum of styrenes and carboxylic acids to deliver the corresponding products in moderate to excellent yields, providing convenient approach to beta-acyloxyselenides.

Safety of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Chen, JY; Chen, R; Mei, L; Yan, SS; Wu, Y; Li, Q; Yuan, BF or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Direct Hydrofluorination of Methallyl Alkenes Using a Methanesulfonic Acid/Triethylamine Trihydrofluoride Combination WOS:000502163300099 published article about FLUORINE in [Bertrand, Xavier; Paquin, Jean-Francois] Univ Laval, Dept Chim, PROTEO, CCVC, 1045 Ave Med, Quebec City, PQ G1V 0A6, Canada in 2019.0, Cited 27.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Name: 4-Nitrobenzoic acid

The use of a methanesulfonic acid/triethylamine trihydrofluoride combination for the direct hydrofluorination of methallyl-containing substrates is reported. Under those metal-free conditions that use readily available, cheap, and easy to handle reagents, a range of methallyl alkenes could be converted to their corresponding tertiary fluoride in up to 78% yield. Finally, a promising result for the adaptation of this chemistry to continuous flow conditions is reported.

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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 ORG LETT published article about RH-CATALYZED AMINATION; C-H AMINATION; ENANTIOSELECTIVE SYNTHESIS; STEREOSELECTIVE-SYNTHESIS; NITROGEN-HETEROCYCLES; ASYMMETRIC-SYNTHESIS; RING EXPANSION; PENARESIDIN; AZETIDINES; BONDS in [Betz, Kerry N.; Chiappini, Nicholas D.; Du Bois, J.] Stanford Univ, Dept Chem, 337 Campus Dr, Stanford, CA 94305 USA; [Chiappini, Nicholas D.] Princeton Univ, Dept Chem, Frick Chem Lab, Washington Rd, Princeton, NJ 08544 USA in 2020.0, Cited 46.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7

The preparation of substituted azetidines and larger ring, nitrogen-containing saturated heterocycles is enabled through efficient and selective intermolecular sp(3)-C-H amination of alkyl bromide derivatives. A range of substrates are demonstrated to undergo C-H amination and subsequent sulfamate alkylation in good to excellent yield. N-Phenoxysulfonyl-protected products can be unmasked under neutral or mild basic conditions to yield the corresponding cyclic. secondary amines. The preparative convenience of this protocol is demonstrated through gram-scale and telescoped multistep procedures. Application of this technology is highlighted in a nine-step total synthesis of an unusual azetidine-containing natural product, penaresidin B.

Product Details of 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2020.0 BIOORG MED CHEM LETT published article about ALZHEIMERS-DISEASE; KEAP1-NRF2-ARE PATHWAY; 1,2,4-OXADIAZOLE CORE; DISCOVERY; TARGET; POLYPHENOL; HYPOTHESIS; MODULATORS; DEMENTIA; ENZYMES in [Lin, Hongzhi; Qiao, Yuting; Yang, Hongyu; Li, Qi; Sun, Haopeng] China Pharmaceut Univ, Dept Med Chem, Nanjing 211198, Jiangsu, Peoples R China; [Feng, Feng] Jiangsu Food & Pharmaceut Sci Coll, Huaian 223003, Peoples R China; [Chen, Yao] Nanjing Univ Chinese Med, Sch Pharm, Nanjing 210023, Jiangsu, Peoples R China; [Qu, Wei] China Pharmaceut Univ, Dept Nat Med Chem, Nanjing 211198, Jiangsu, Peoples R China; [Liu, Wenyuan] China Pharmaceut Univ, Dept Analyt Chem, Nanjing 210009, Jiangsu, Peoples R China in 2020.0, Cited 35.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Quality Control of 4-Nitrobenzoic acid

Oxidative stress plays vital roles in virous neurodegenerative diseases including Alzheimer’s disease. Activation of the transcription factor Nrf2 (nuclear factor erythroid 2-related factor 2), the key regulator of oxidative stress, may provide a new therapeutic strategy for these diseases. Herein we synthesized and evaluated a series of 1,3,4-oxa/thiadiazole core Nrf2 activators as neuroprotective agents. The representative compound 8 exhibited cytoprotective and Nrf2 activation effects in a neuron-like PC-12 cells. Additionally, compound 8 showed good membrane permeability, indicating this compound could penetrate blood-brain barrier (BBB) to reach central nervous system (CNS) as a neuro-protective agent. These results indicated that these Nrf2 activators with 1,3,4-oxa/thiadiazole core could serve as a new chemotype against oxidative stress in neurodegenerative diseases.

Quality Control of 4-Nitrobenzoic acid. Welcome to talk about 62-23-7, If you have any questions, you can contact Lin, HZ; Qiao, YT; Yang, HY; Li, Q; Chen, Y; Qu, W; Liu, WY; Feng, F; Sun, HP or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Copper iodide nanoparticles-decorated porous polysulfonamide gel: As effective catalyst for decarboxylative synthesis of N-Arylsulfonamides WOS:000506296600001 published article about ONE-POT SYNTHESIS; REUSABLE CATALYST; CUI NANOPARTICLES; PALLADIUM NANOPARTICLES; SULFONAMIDE DERIVATIVES; HIGHLY EFFICIENT; ARYL BROMIDES; MILD; ARYLATION; HALIDES in [Alavinia, Sedigheh; Ghorbani-Vaghei, Ramin; Arabian, Iman Ali] Bu Ali Sina Univ, Fac Chem, Dept Organ Chem, Hamadan 65174, Hamadan, Iran; [Rakhtshah, Jamshid] Univ Tabriz, Fac Chem, Dept Inorgan Chem, Tabriz, Iran; [Seyf, Jaber Yousefi] Univ Technol, Dept Chem Engn, Hamadan, Hamadan, Iran in 2020, Cited 58. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. SDS of cas: 62-23-7

A porous cross-linked poly (ethyleneamine)-polysulfonamide (PEA-PSA) as a novel organic support system is synthesized in the presence of silica template by nanocasting technique. The paper demonstrates immobilization of CuI nanoparticles inside the pores (PEA-PSA@CuI) for the facile recovery and recycling of these nanoparticles. The presence of porous PEA-PSA and PEA-PSA@CuI nanocomposites was confirmed using FT-IR spectroscopy, FE-SEM, EDX, TGA, XRD, TEM, BET, XPS, WDX, H-1 NMR, and ICP-OES techniques. The PEA-PSA@CuI along with Ag(I)/K2S2O8 was implemented as a reusable cooperative catalyst-oxidant system in the N-arylation of p-toluenesulfonamide with substituted carboxylic acids in mild condition. So, the novel decarboxylative cross-coupling catalyzed by copper and silver has been developed. Aromatic, secondary and tertiary aliphatic acids underwent high efficient decarboxylative processes with p-toluenesulfonamide to afford the corresponding products. This method provides a practical approach for the flexible synthesis of sulfonamides from the readily affordable substrates. The catalyst is highly reusable and efficient, especially in terms of time and yield of the desired product.

SDS of cas: 62-23-7. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. Pathak, P; Shukla, PK; Naumovich, V; Grishina, M; Potemkin, V; Verma, A in [Pathak, Prateek; Naumovich, Vladislav; Grishina, Maria; Potemkin, Vladimir] South Ural State Univ, Higher Med & Biol Sch, Lab Modeling Drugs, Tchaikovsky Str 20-A, Chelyabinsk 454008, Russia; [Shukla, Parjanya Kumar; Verma, Amita] Sam Higginbottom Univ Agr Technol & Sci, Fac Hlth Sci, Dept Pharmaceut Sci, Bioorgan & Med Chem Res Lab, Allahabad 211007, Uttar Pradesh, India; [Shukla, Parjanya Kumar] Uttar Pradesh Tech Univ, Krishnarpit Inst Pharm, Allahabad, Uttar Pradesh, India published Silica catalyzed one pot synthesis of hybrid thiazolidin-4-one derivatives as anti-tubercular and anti-inflammatory agent by attenuating COX-2 pathway in 2019, Cited 49. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

A novel series of a hybrid class of hybrid thiazolidin-4-one derivatives were designed and synthesized through one-pot catalytic synthesis. The reaction was catalyzed in the presence of silica-H(2)SO4((+6)). The derivatives computational ADMET profile was calculated. The study shows that most active derivatives have optimal logP, higher anti-inflammatory activity score, and poor metabolism at the sight of P450-3A4 and 2D6. The entire series of derivatives were further evaluated for anti-tubercular (against Mycobacterium tuberculosis H37Rv (Resistant strain)) and anti-inflammatory activity (in-vivo assay using Wistar rat). The result showed that derivatives 4c, 4h, and 4m have significant potency against tested M. tuberculosis. However, derivatives 4i and 4j found significantly active against inflammation. In vitro COX inhibition assay also supported the result in favor of selectivity and efficacy of derivatives. [GRAPHICS] .

Formula: C7H5NO4. Bye, fridends, I hope you can learn more about C7H5NO4, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem