Month: November 2021

HPLC of Formula: C7H5NO4. In 2020.0 ORG LETT published article about PICTET-SPENGLER REACTIONS; SP(3) C-H; INDOLE SYNTHESIS; IODINE(III) REAGENTS; AMINATION; EFFICIENT; FUNCTIONALIZATION; BONDS; TETRAHYDROISOQUINOLINES; ALKYLATION in [Choi, Subin; Oh, Hyeonji; Sim, Jeongwoo; Yu, Eunsoo; Park, Cheol-Min] UNIST Ulsan Natl Inst Sci & Technol, Dept Chem, Ulsan 44919, South Korea; [Shin, Seunghoon] Hanyang Univ, Dept Chem, Seoul 04763, South Korea in 2020.0, Cited 73.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

The synthesis of versatile scaffold indolopyrans based on C-C radical-radical cross-coupling under metal-free conditions is described. The reaction involving single electron transfer between coupling partners followed by cage collapse allows highly selective cross-coupling while employing only equimolar amounts of coupling partners. Moreover, the mechanistic manifold was expanded for the functionalization of enamines to give the stereoselective synthesis of 2,3-dihydrofurans. This iodine-mediated oxidative coupling features mild conditions and fast reaction kinetics.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Choi, S; Oh, H; Sim, J; Yu, E; Shin, S; Park, CM or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ORG LETT published article about TRACELESS DIRECTING GROUPS; CARBOXYLIC-ACIDS; ENANTIOSELECTIVE SYNTHESIS; COUPLING REACTIONS; ORTHO-ARYLATION; BENZOIC-ACIDS; IODINE; ACTIVATION; BIARYLS; ALKYNES in [Hu, Tao; Xu, Kai; Ye, Zenghui; Zhu, Kai; Zhang, Fengzhi] Zhejiang Univ Technol, Coll Pharmaceut Sci, Hangzhou 310014, Zhejiang, Peoples R China; [Wu, Yanqi] Zhejiang Univ Technol, Inst Informat Resource, Hangzhou 310014, Zhejiang, Peoples R China in 2019.0, Cited 63.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Product Details of 62-23-7

We report here a two-in-one strategy for the Pd(II)-catalyzed tandem C-H arylation/decarboxylative annulation between readily available cyclic diaryliodonium salts and benzoic acids. The carboxylic acid functionality can be used as both a directing group for the ortho-C-H arylation and the reactive group for the tandem decarboxylative annulation. By a step-economical double cross-coupling annulation procedure, the privileged triphenylene frameworks were efficiently constructed, which have potential applications in material chemistry.

Product Details of 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Hu, T; Xu, K; Ye, ZH; Zhu, K; Wu, YQ; Zhang, FZ or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

An article Iron(III)-catalyzed direct synthesis of diphenylmethyl esters from 2-diphenylmethoxypyridine WOS:000472440400001 published article about SULFUR-CONTAINING POLYPEPTIDES; PEPTIDES; ACIDS in [Van Hieu Tran; Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ, Mol Imaging & Therapeut Med Res Ctr, Dept Nucl Med, Med Sch & Hosp, Jeonju 54907, South Korea; [Van Hieu Tran; Minh Thanh La; Kim, Hee-Kwon] Chonbuk Natl Univ Hosp, Natl Univ Biomed Res Inst, Res Inst Clin Med Chonbuk, Jeonju 54907, South Korea in 2019, Cited 26. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

A highly efficient method has been developed for the synthesis of diphenylmethyl (DPM) esters from 2-diphenylmethoxypyridine. Various carboxylic acids readily reacted with 2-diphenylmethoxypyridine in the presence of FeCl3 as a catalyst to provide the desired DPM esters with high yields. The procedure is facile and enables effective synthesis of a variety of esters for the protection of carboxylic acids. [GRAPHICS] .

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Tran, VH; La, MT; Kim, HK or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about INTRAMOLECULAR CHARGE-TRANSFER; PICRIC ACID; PHOTOPHYSICAL PROPERTIES; LUMINESCENT MATERIALS; SELECTIVE DETECTION; SENSITIVITY; DERIVATIVES; EFFICIENT; EMISSION; MOLECULE, Saw an article supported by the Russian Foundation for Basic ResearchRussian Foundation for Basic Research (RFBR) [18-29-23045 mk]; Ministry of Education and Science of the Russian FederationMinistry of Education and Science, Russian Federation. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Verbitskiy, EV; Rusinov, GL; Chupakhin, ON; Charushin, VN. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. HPLC of Formula: C7H5NO4

Highly sensitive and selective detection of nitro containing high energy organic compounds such as picric acid (PA), 2,4,6-trinitrotoluene (TNT) and 2,4-dinitrotoluene (DNT) has become a challenging task due to concerns over national security, criminal investigations and environment protections. Among various known detection methods, fluorescence sensors have gained special attention in recent time. The family of fluorescent sensors based on push-pull systems that incorporate nitrogen heterocycles as an electron-withdrawing group have a growing interest due to their high sensitivity, selectivity and easy tuning. The fluorescent sensors discussed in this review are classified and organized according to used azahetemcyclic scaffold, their functionality and their ability to detect of nitmaromatics by fluorescence quenching.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Verbitskiy, EV; Rusinov, GL; Chupakhin, ON; Charushin, VN or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ANGEW CHEM INT EDIT published article about H BOND FUNCTIONALIZATION; CROSS-COUPLING REACTIONS; ALKENES; PALLADIUM; MECHANISM; OLEFINS; STYRENES; GOLD; MARKOVNIKOV; DERIVATIVES in [Ahmed, Waqar; Zhang, Sheng; Yu, Xiaoqiang; Feng, Xiujuan; Yamamoto, Yoshinori; Bao, Ming] Dalian Univ Technol, State Key Lab Fine Chem, Dalian 116023, Peoples R China; [Ahmed, Waqar; Zhang, Sheng; Yu, Xiaoqiang; Feng, Xiujuan; Yamamoto, Yoshinori; Bao, Ming] Dalian Univ Technol, Sch Petr & Chem Engn, Panjin 124221, Peoples R China; [Yamamoto, Yoshinori] Ritsumeikan Univ, Res Org Sci & Technol, Shiga 5258577, Japan in 2019.0, Cited 75.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. HPLC of Formula: C7H5NO4

The cooperative catalysis of copper, silver, and Bronsted acid is presented as a new strategy for olefin functionalization. The catalytic direct carbohydroxylation of arylalkenes with allylic alcohols provided a straightforward and efficient approach for preparing 4,5-unsaturated alcohols. Synthetically useful functional groups, such as Cl, Br, carbonyl, and chloromethyl, remained intact during the functionalization reaction.

HPLC of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Ahmed, W; Zhang, S; Yu, XQ; Feng, XJ; Yamamoto, Y; Bao, M or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Recently I am researching about SELECTIVE AEROBIC OXIDATION; HYDROGEN-PEROXIDE; ELECTRON-TRANSFER; MOLECULAR-OXYGEN; BUILDING-BLOCKS; IRON CATALYSIS; SOFT OXIDANT; ALDEHYDES; CARBON; SILICOTUNGSTATE, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21871183, 21971134, 21631007, 21471087, 21225103]; Doctoral Fund of Ministry of Education of ChinaMinistry of Education, China [20130002110042]; Tsinghua University Initiative Foundation Research Program [20131089204]; State Key Laboratory of Natural and Biomimetic Drugs [K20160202]; Shanghai Institute of Technology. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Wan, Y; Wu, ZK; Yu, H; Han, S; Wei, YG. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid. COA of Formula: C7H5NO4

Direct catalytic oxidation of alcohols to carboxylic acids is very attractive, but economical catalysis systems have not yet been well established. Here, we show that a pure inorganic ligand-supported chromium compound, (NH4)(3)[CrMo6O18(OH)(6)] (simplified as CrMo6), could be used to effectively promote this type of reaction in the presence of CO2. In almost all cases, oxidation of various alcohols (aromatic and aliphatic) could be achieved under mild conditions, and the corresponding carboxylic acids can be achieved in high yield. The chromium catalyst 1 can be reused several times with little loss of activity. Mechanism study and control reactions demonstrate that the acidification proceeds via the key oxidative immediate of aldehydes.

COA of Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Wan, Y; Wu, ZK; Yu, H; Han, S; Wei, YG or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Authors Seubert, P; Freund, M; Rudolf, R; Lin, YL; Altevogt, L; Bilitewski, U; Baro, A; Laschat, S in GEORG THIEME VERLAG KG published article about PSEUDOMONAS-AERUGINOSA; SIDEROPHORES; BIOSYNTHESIS in [Seubert, Philipp; Freund, Marcel; Rudolf, Richard; Lin, Yulin; Altevogt, Luca; Baro, Angelika; Laschat, Sabine] Univ Stuttgart, Inst Organ Chem, Pfaffenwaldring 55, D-70569 Stuttgart, Germany; [Altevogt, Luca; Bilitewski, Ursula] Helmholtz Zentrum Infekt Forsch, AG Compound Profiling & Screening, Inhoffenstr 7, D-38124 Braunschweig, Germany in 2020.0, Cited 20.0. SDS of cas: 62-23-7. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7

The reaction of 2-chloro-6,7-dimethoxy-3-nitroquinoline with a series of amines and aminoalkanoates under basic microwave-mediated conditions and under Buchwald-Hartwig amination conditions is reported. The microwave irradiation favored the reaction with amines, resulting in yields of up to 80%, whereas amino acid functionalization gave yields comparable to those of Buchwald-Hartwig amination. tert-Butyl (2R)-4-[(6,7-dimethoxy-3-nitroquinolin-2-yl)amino]-2-hydroxybutanoate was successfully cyclized to the pyoverdin chromophore, a subunit of siderophores.

SDS of cas: 62-23-7. Welcome to talk about 62-23-7, If you have any questions, you can contact Seubert, P; Freund, M; Rudolf, R; Lin, YL; Altevogt, L; Bilitewski, U; Baro, A; Laschat, S or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

Formula: C7H5NO4. In 2019.0 TETRAHEDRON LETT published article about PHOSPHONIUM IONIC LIQUIDS; AROMATIC-COMPOUNDS; SOLVOLYTIC BEHAVIOR; SELECTIVE NITRATION; ARYLBORONIC ACIDS; HIGHLY EFFICIENT; SULFONIC-ACID; METAL; CHEMISTRY; CATALYST in [Natarajan, Palani] Panjab Univ, Dept Chem, Chandigarh 160014, India; Panjab Univ, Ctr Adv Studies Chem, Chandigarh 160014, India in 2019.0, Cited 83.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7.

An eco-friendly and a simple ipso-nitration protocol for a series of aliphatic and (hetero)aromatic carboxylic acids using nitronium tetrafluoroborate, 1-hexyl-3,4,5-trimethyl-1H-imidazolium tetrafluoroborate and base is reported. While contrasted with recently known decarboxylative ipso-nitration strategies for the preparation of nitro compounds, this protocol does not require a toxic metal catalyst and harmful volatile organic solvents. Moreover, this method is perfect for a broad range of functional groups and affords exclusively the ipso-nitrated product in moderate to good yields. (C) 2019 Elsevier Ltd. All rights reserved.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Natarajan, P; Chaudhary, R; Venugopalan, P or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

I found the field of Pharmacology & Pharmacy very interesting. Saw the article Synthesis, biological evaluation and mechanism studies of C-23 modified 23-hydroxybetulinic acid derivatives as anticancer agents published in 2019. Computed Properties of C7H5NO4, Reprint Addresses Xu, JY (corresponding author), China Pharmaceut Univ, State Key Lab Nat Med, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China.; Xu, JY (corresponding author), China Pharmaceut Univ, Dept Med Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China.; Liu, J (corresponding author), China Pharmaceut Univ, Dept Organ Chem, 24 Tong Jia Xiang, Nanjing 210009, Jiangsu, Peoples R China.. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid

A series of C-23 modified 23-hydroxybetulinic acid (HBA) derivatives were synthesized and evaluated for their antiproliferative activity against a panel of cancer cell lines (A2780, A375, B16, MCF-7 and HepG2). The biological screening results showed that most of the derivatives exhibited more potent antiproliferative activity than HBA, and compound 6e exhibited the most potent activity with IC50 values of 2.14 mu M, 2.89 mu M, and 3.97 mu M against A2780, B16, and MCF-7 cells, respectively. Further anticancer mechanism studies revealed that compound 6e induced the generation of intracellular reactive oxygen species (ROS) and reduction of mitochondrial membrane potential (MMP) of B16 cells in a dose-dependent manner. Moreover, western blot analysis indicated that compound 6e downregulated the expression of anti-apoptotic protein Bcl-2 and upregulated the expression of proapoptotic protein Bax, activation of caspase 3 to induce cell apoptosis. Meanwhile, compound 6e significantly inhibited the phosphorylation of MEK, ERK, and Akt without affecting the expression of MEK, ERK, and Akt. Furthermore, the in vivo anti-tumor activity of 6e was validated (tumor inhibitory ratio of 68.4% at the dose of 30 mg/kg) in mice with B16 melanoma. (C) 2019 Elsevier Masson SAS. All rights reserved.

Computed Properties of C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Lu, LX; Zhang, HY; Liu, J; Liu, Y; Wang, YW; Xu, ST; Zhu, ZY; Xu, JY or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem

In 2019.0 ORG CHEM FRONT published article about ASYMMETRIC-SYNTHESIS; QUATERNARY CARBON; ALPHA(2C)-ADRENOCEPTOR ANTAGONIST; STEREOSELECTIVE CONSTRUCTION; REDUCTION; DELTA(3)-2-HYDROXYBAKUCHIOL; ACIDS in [Ma, Qiaoning; Lei, Xinsheng; Lin, Guo-Qiang] Fudan Univ, Inst Biomed Sci, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Ma, Qiaoning; Lei, Xinsheng; Lin, Guo-Qiang] Fudan Univ, Sch Pharm, 826 Zhangheng Rd, Shanghai 201203, Peoples R China; [Yang, Xiaodi; Lin, Guo-Qiang] Shanghai Univ Tradit Chinese Med, Expt Ctr Sci & Technol, Shanghai 201203, Peoples R China; [Lin, Guo-Qiang] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, Key Lab Synthet Chem Nat Subst, 345 Lingling Rd, Shanghai 200032, Peoples R China in 2019.0, Cited 32.0. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7. Formula: C7H5NO4

The preparation of ORM-10921, a selective (2C)-adrenoceptor antagonist with promising anti-psychotic properties, was successfully achieved using asymmetric -alkylation of ,-unsaturated imide and Bischler-Napieralski cyclization/asymmetric reduction as the key steps. When the tetracyclic iminium 11S was used in the reduction, the diastereo-selectivity was poor, from which four stereoisomers of ORM-10921 were obtained, respectively. However, the diastereoselectivity could be significantly improved (with dr up to >97:3) when the tricyclic imine substrate 19S was applied in this reduction, suggesting an additional chelation from the side-chain methoxy group in the transition state. According to this protocol, ORM-10921 was accomplished in a highly enantioselective manner. In addition, two analogs 26Aa and 26Ba were prepared using this novel method, and the absolute configurations were unambiguously assigned by single crystal X-ray crystallography.

Formula: C7H5NO4. Welcome to talk about 62-23-7, If you have any questions, you can contact Ma, QN; Yang, XD; Lei, XS; Lin, GQ or send Email.

Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem