An article Synthesis, in vitro and in silico Anti-Proliferative Studies of Novel Piperiene-Oxadiazole and Thiadiazole Analogs WOS:000511198000022 published article about ANTITUMOR EFFICACY; DERIVATIVES in [Amperayani, K. R.; Parimi, U. D.] GVP Degree & PG Coll, Dept Chem, Visakhapatnam 530045, Andhra Pradesh, India in 2019, Cited 25. COA of Formula: C7H5NO4. The Name is 4-Nitrobenzoic acid. Through research, I have a further understanding and discovery of 62-23-7
Piperine is a component of pepper which has earlier been reported as anticancer active compound. This work is emphasized on the design and synthesis of new hybrid piperine analogs by coupling piperine with the amine group of oxadiazoles and thiadiazoles. The new series of twelve piperine analogs was been tested for in vitro anti-proliferative activity using sulforhodamine B (SRB) assay test against MCF-7, PC-3, and HeLa cell lines. Among the twelve synthesised molecules piperine derivative with oxadiazole baring hydroxyl group (3) exhibits the higher activity against MCF-7 cell line than the reference drug Adriamycin and also displays the highest binding energy in the in silico studies. The other analogs are moderately active.
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Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem