Recently I am researching about GOLD-CATALYZED SYNTHESIS; EFFICIENT SYNTHESIS; CHIRALITY TRANSFER; CYCLIZATION; YNAMIDES; CYCLOISOMERIZATION; CYCLOADDITION; CONSTRUCTION; CARBON; ACID, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772161, 21622204]; Fundamental Research Funds for the Central UniversitiesFundamental Research Funds for the Central Universities [20720180036]; PCSIRTProgram for Changjiang Scholars & Innovative Research Team in University (PCSIRT); NFFTBS [J1310024]; Science & Technology Cooperation Program of Xiamen [3502Z20183015]; Young Top-notch Talent Support Program of Fujian Province; XMU Undergraduate Innovation and Entrepreneurship Training Programs. Category: phthalazines. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Li, L; Zhu, XQ; Zhang, YQ; Bu, HZ; Yuan, P; Chen, JY; Su, JY; Deng, XM; Ye, LW. The CAS is 62-23-7. Through research, I have a further understanding and discovery of 4-Nitrobenzoic acid
Alkene carbooxygenation has attracted considerable attention over the past few decades as this approach provides an efficient access to various oxygen-containing molecules, especially the valuable O-heterocycles. However, examples of catalytic alkene carbooxygenation via a direct C-O cleavage are quite scarce, and the C-O cleavage in these cases is invariably initiated by transition metal-catalyzed oxidative addition. We report here a novel Bronsted acid-catalyzed intramolecular alkoxylation-initiated tandem sequence, which represents the first metal-free intramolecular alkoxylation/Claisen rearrangement. Significantly, an unprecedented Bronsted acid-catalyzed intramolecular alkene insertion into the C-O bond via a carbocation pathway was discovered. This method allows the stereocontrolled synthesis of valuable indole-fused bridged [4.2.1] lactones, providing ready access to biologically relevant scaffolds in a single synthetic step from an acyclic precursor. Moreover, such an asymmetric cascade cyclization has also been realized by employing a traceless chiral directing group. Control experiments favor the feasibility of a carbocation pathway for the process. In addition, biological tests showed that some of these newly synthesized indole-fused lactones exhibited their bioactivity as antitumor agents against different breast cancer cells, melanoma cells, and esophageal cancer cells.
Welcome to talk about 62-23-7, If you have any questions, you can contact Li, L; Zhu, XQ; Zhang, YQ; Bu, HZ; Yuan, P; Chen, JY; Su, JY; Deng, XM; Ye, LW or send Email.. Category: phthalazines
Reference:
Phthalazine – Wikipedia,
,Phthalazine | C8H6N2 – PubChem